2022
Evolocumab on top of empagliflozin improves endothelial function of individuals with diabetes: randomized active-controlled trial
Sposito A, Breder I, Barreto J, Breder J, Bonilha I, Lima M, Oliveira A, Wolf V, Luchiari B, do Carmo H, Munhoz D, Oliveira D, Coelho-Filho O, Coelho O, Matos-Souza J, Moura F, de Carvalho L, Nadruz W, Quinaglia T, Kimura-Medorima S. Evolocumab on top of empagliflozin improves endothelial function of individuals with diabetes: randomized active-controlled trial. Cardiovascular Diabetology 2022, 21: 147. PMID: 35933413, PMCID: PMC9356512, DOI: 10.1186/s12933-022-01584-8.Peer-Reviewed Original ResearchConceptsFlow-mediated dilationEndothelial functionPost-treatment changesPlasma levelsPlasma levels of nitric oxide metabolitesBackgroundSodium-glucose cotransporter 2 inhibitorsCardiovascular eventsInhibitors reduce cardiovascular eventsLevels of nitric oxide metabolitesE groupPlasma levels of nitrateEE groupHigh-risk patientsProprotein convertase subtilisin/kexin 9Nitric oxide metabolitesRandomized active-controlled trialActive-controlled trialReduce cardiovascular eventsType 2 diabetesPCSK9-iSGLT2i treatmentPrimary endpointSGLT2-iEndothelial dysfunctionSecondary outcomes
2017
Sarcopenia, but not excess weight or increased caloric intake, is associated with coronary subclinical atherosclerosis in the very elderly
Campos A, Moura F, Santos S, Freitas W, Sposito A, Study O. Sarcopenia, but not excess weight or increased caloric intake, is associated with coronary subclinical atherosclerosis in the very elderly. Atherosclerosis 2017, 258: 138-144. PMID: 28129889, DOI: 10.1016/j.atherosclerosis.2017.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptiometry, PhotonAdiposityAge FactorsAged, 80 and overAsymptomatic DiseasesBody CompositionCoronary AngiographyCoronary Artery DiseaseCross-Sectional StudiesEndothelium, VascularEnergy IntakeExercise TestExercise ToleranceFemaleGeriatric AssessmentHumansLogistic ModelsMaleMultidetector Computed TomographyMultivariate AnalysisMuscle StrengthMuscle, SkeletalNutrition AssessmentNutritional StatusOdds RatioOverweightProspective StudiesRisk FactorsSarcopeniaVasodilationWeight GainConceptsCoronary heart diseaseAssociated with subclinical atherosclerosisCoronary calcium scoreFlow-mediated dilationExcess weightSubclinical atherosclerosisOdds ratioFatty massMuscle massPhysical performance testsCoronary heart disease riskElderly individualsRisk of coronary heart diseaseAssociated with coronary heart diseaseCaloric intakeIncreased risk of coronary heart diseaseStudy of CohortsEndothelial dysfunctionCross-sectional studySkeletal muscle indexAssociated with flow-mediated dilationGait speedCardiac computed tomographyReduction of muscle massMultivariate regression model
2014
Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly
De Paula RC, Aneni EC, Costa AP, Figueiredo VN, Moura FA, Freitas WM, Quaglia LA, Santos SN, Soares AA, Nadruz W, Blaha M, Blumenthal R, Agatston A, Nasir K, Sposito AC, Group O. Low zinc levels is associated with increased inflammatory activity but not with atherosclerosis, arteriosclerosis or endothelial dysfunction among the very elderly. BBA Clinical 2014, 2: 1-6. PMID: 26676114, PMCID: PMC4633969, DOI: 10.1016/j.bbacli.2014.07.002.Peer-Reviewed Original ResearchFlow-mediated dilationC-reactive proteinDaily intakeEndothelial dysfunctionInflammatory activityCoronary plaquesPlasma levelsPlasma zincCarotid intima-media thicknessZinc levelsArterial wallNoncalcified coronary plaquesAnti-inflammatory treatmentCarotid plaque presenceCRP plasma levelsPlasma CRP levelsSystemic inflammatory activityCoronary calcium scoreIntima-media thicknessCardiac computed tomographyPlasma zinc levelsSignificant differencesLow zinc levelsAverage daily intakeAtherosclerotic burden