P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury
Luz H, Reichel M, Unwin R, Mutig K, Najenson A, Tonner L, Eckardt K, Tam F, Knauf F. P2X7 Receptor Stimulation Is Not Required for Oxalate Crystal-Induced Kidney Injury. Scientific Reports 2019, 9: 20086. PMID: 31882798, PMCID: PMC6934555, DOI: 10.1038/s41598-019-56560-2.Peer-Reviewed Original ResearchConceptsIL-1ß releaseDendritic cellsKidney failureP2X7 receptorBone marrowNLRP3/CASPP2X7 receptor signalingProgressive kidney diseaseSuitable therapeutic targetProgressive kidney failureMonosodium urate crystalsHuman peripheral bloodKidney injuryRenal inflammationRenal injuryTubular damageWT miceIL-1ßKidney diseasePeripheral bloodCytokine releasePlasma creatinineMurine bone marrowInterleukin-1betaInflammasome activationA preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice
Ferraro P, Arrabal-Polo M, Capasso G, Croppi E, Cupisti A, Ernandez T, Fuster D, Galan J, Grases F, Hoorn E, Knauf F, Letavernier E, Mohebbi N, Moochhala S, Petkova K, Pozdzik A, Sayer J, Seitz C, Strazzullo P, Trinchieri A, Vezzoli G, Vitale C, Vogt L, Unwin R, Bonny O, Gambaro G. A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice. Urolithiasis 2019, 47: 219-224. PMID: 30848320, DOI: 10.1007/s00240-019-01119-z.Peer-Reviewed Original ResearchConceptsKidney Stone CenterStone CenterPractice patternsUrine samplesRecruitment of patientsEvidence-based approachMore patientsInterventional studyReferral criteriaStone eventsUrine collectionKind of imagingClinical careBlood samplesFormal followMonthsPatientsVoluntary online questionnaireClinical fieldBaselineLaboratory analysisPilot surveyOnline questionnaireNephrolithiasis