2011
The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons
Corti F, Olson K, Marcus A, Levi R. The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons. Journal Of Pharmacology And Experimental Therapeutics 2011, 337: 524-532. PMID: 21325440, PMCID: PMC3083107, DOI: 10.1124/jpet.111.179994.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntigens, CDApyraseBlotting, WesternDNA PrimersDopamineExocytosisGene Expression Regulation, EnzymologicGene SilencingIschemiaNerve Growth FactorsNeuronsNeurotransmitter AgentsNorepinephrinePC12 CellsPotassiumRatsReceptors, Purinergic P2XReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingSympathetic Nervous SystemConceptsE-NTPDase1/CD39CD39 expressionTransmitter ATPSympathetic neuronsDopamine releaseExcessive catecholamine releaseNerve growth factor-differentiated PC12 cellsSympathetic nerve terminalsPC12 cellsExocytosis of ATPCellular modelRelease of ATPCD39 overexpressionIschemic releasePrejunctional siteSympathetic nervesCardiac dysfunctionMyocardial ischemiaCatecholamine releaseCD39 deletionNerve terminalsDepolarization-induced exocytosisAutocrine mannerDiphosphohydrolase-1Predominant catecholamine
2010
Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction
Morrey C, Brazin J, Seyedi N, Corti F, Silver RB, Levi R. Interaction between Sensory C-fibers and Cardiac Mast Cells in Ischemia/Reperfusion: Activation of a Local Renin-Angiotensin System Culminating in Severe Arrhythmic Dysfunction. Journal Of Pharmacology And Experimental Therapeutics 2010, 335: 76-84. PMID: 20668055, PMCID: PMC2957783, DOI: 10.1124/jpet.110.172262.Peer-Reviewed Original ResearchMeSH KeywordsAldehydesAnimalsArrhythmias, CardiacBeta-N-AcetylhexosaminidasesCalcitonin Gene-Related PeptideCell DegranulationCells, CulturedFluorescent Antibody TechniqueGuinea PigsIn Vitro TechniquesMaleMast CellsMyocardial Reperfusion InjuryMyocardiumNerve EndingsNerve Fibers, UnmyelinatedNorepinephrineReninRenin-Angiotensin SystemSensory Receptor CellsSubstance PSynaptosomesConceptsRenin-angiotensin systemIschemia/reperfusionCardiac mast cellsSubstance P receptor blockadeLocal renin-angiotensin systemSubstance PMast cellsSensory nervesCultured mast cellsRenin releaseReceptor blockadeCardiac dysfunctionLocal cardiac renin-angiotensin systemCardiac renin-angiotensin systemCardiac nerve terminalsCardiac sensory nervesMast cell reninSubstance P releaseSensory C-fibersMast cell stabilizationSubstance P receptorCardiac synaptosomesReperfusion arrhythmiasNorepinephrine overflowAngiotensin production