2023
A unifying mechanism for the initiation of torsade de pointes: blurring the distinction between trigger and substrate
McKay M, Akar F. A unifying mechanism for the initiation of torsade de pointes: blurring the distinction between trigger and substrate. Cardiovascular Research 2023, 119: 333-335. PMID: 36869679, DOI: 10.1093/cvr/cvad033.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2002
Unique Topographical Distribution of M Cells Underlies Reentrant Mechanism of Torsade de Pointes in the Long-QT Syndrome
Akar FG, Yan GX, Antzelevitch C, Rosenbaum DS. Unique Topographical Distribution of M Cells Underlies Reentrant Mechanism of Torsade de Pointes in the Long-QT Syndrome. Circulation 2002, 105: 1247-1253. PMID: 11889021, DOI: 10.1161/hc1002.105231.Peer-Reviewed Original ResearchConceptsLong QT syndromeSpecific ion channel mutationsCongenital long QT syndromeM cellsQT interval prolongationIon channel mutationsInterval prolongationReentrant mechanismTdP arrhythmiasConduction blockCanine wedge preparationReentrant circuitTransmural dispersionLeft ventricleAction potentialsTransmural wallIntact myocardiumTopographical distributionChannel mutationsWedge preparationsMidmyocardial cellsRepolarizationLQT2Cellular basisElectrical instability