2024
Clinician and Practice Characteristics Associated With Support of Office-Based Methadone: Findings From a National Survey.
Sung M, Black A, Blevins D, Henry B, Cates-Wessel K, Dawes M, Hagle H, Joudrey P, Molfenter T, Levin F, Fiellin D, Edelman E. Clinician and Practice Characteristics Associated With Support of Office-Based Methadone: Findings From a National Survey. Journal Of Addiction Medicine 2024 PMID: 39475119, DOI: 10.1097/adm.0000000000001388.Peer-Reviewed Original ResearchOpioid use disorderCharacteristics associated with supportTreatment of opioid use disorderMultivariate logistic regression modelOffice-based settingSequential multivariable logistic regression modelsOpioid treatment programsLogistic regression modelsAcademic medical centerUse disorderInclusion criteriaMethadoneMedical CenterPatientsOffice-basedCOVID-19 surveyClinician supportPractice characteristicsLongitudinal treatmentImplementation barriersPolicy changesMOUDOutcome variablesImprove accessNational surveyA call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions
Belmont A, Stone C, Guyer A, Edelman E, Trubiano J. A call to address penicillin allergy labels in patients with hematopoietic stem cell transplants: How to avoid rash decisions. Transplant Infectious Disease 2024, 26: e14350. PMID: 39101669, PMCID: PMC11502247, DOI: 10.1111/tid.14350.Peer-Reviewed Original ResearchHematopoietic stem cell transplantationStem cell transplantationPenicillin allergy labelMultidrug-resistant infectionsPenicillin allergyCell transplantationAllergy labelsAssociated with more severe infectionsReported penicillin allergyRisk-stratify patientsMore severe infectionsPoint-of-care assessmentBeta-lactam antibioticsClinical decision toolTolerate penicillinsAssociated with useDelabel patientsTherapeutic optionsEvaluating patientsSevere infectionsAlternative antibioticsOral challengeClinical care settingsClostridium difficilePatients
2023
Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV
Cohen S, DePhilippis D, Deng Y, Dziura J, Ferguson T, Fucito L, Justice A, Maisto S, Marconi V, Molina P, Paris M, Rodriguez‐Barradas M, Simberkoff M, Petry N, Fiellin D, Edelman E. Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV. Alcohol Clinical And Experimental Research 2023, 47: 1783-1797. PMID: 37524371, PMCID: PMC10828101, DOI: 10.1111/acer.15159.Peer-Reviewed Original ResearchUnhealthy alcohol useAlcohol useContingency managementPrimary care settingSubset of participantsReward structureEvidence-based approachHIV clinicImplementation science frameworkTreatment trialsClinical trialsIntervention feasibilityCare settingsPromoting ActionAlcohol consumptionRelated conditionsBiochemical testingClinical contextHIVReward schedulePatientsReward processesInterventionTrialsBehavior changeURINE TOXICOLOGY PROFILES OF EMERGENCY DEPARTMENT PATIENTS WITH UNTREATED OPIOID USE DISORDER: A MULTI-SITE VIEW
Cowan E, Perrone J, Dziura J, Edelman E, Hawk K, Herring A, McCormack R, Murphy A, Phadke M, Fiellin D, D'Onofrio G. URINE TOXICOLOGY PROFILES OF EMERGENCY DEPARTMENT PATIENTS WITH UNTREATED OPIOID USE DISORDER: A MULTI-SITE VIEW. Journal Of Emergency Medicine 2023, 65: e357-e365. PMID: 37716904, PMCID: PMC10591927, DOI: 10.1016/j.jemermed.2023.06.007.Peer-Reviewed Original ResearchUrine drug screensOpioid use disorderEmergency departmentUntreated opioid use disorderAdult ED patientsOpioid overdose deathsED patientsOnly opioidCommon opioidsOverdose deathsUse disordersCommon drugsOpioidsPolysubstance useDrug useDrug screensAmphetamine-type stimulantsFentanylPatientsAddiction treatmentStimulantsParticipantsBuprenorphineMethadoneBenzodiazepinesFactors Associated with Bothersome Symptoms in Individuals With and Without HIV Who Report Alcohol Use
Bahji A, Gordon K, Crystal S, Satre D, Wiliams E, Edelman E, Justice A. Factors Associated with Bothersome Symptoms in Individuals With and Without HIV Who Report Alcohol Use. AIDS And Behavior 2023, 27: 2455-2462. PMID: 36622487, PMCID: PMC10225332, DOI: 10.1007/s10461-022-03972-3.Peer-Reviewed Original Research
2022
The impact of benzodiazepine exposure on treatment retention in an open-access methadone program: A retrospective cohort study
Morford K, Tetrault J, Zhou B, Li F, Gleeson B, Edelman E, Stein M, Barry D, Madden L. The impact of benzodiazepine exposure on treatment retention in an open-access methadone program: A retrospective cohort study. Drug And Alcohol Dependence 2022, 241: 109707. PMID: 36423462, PMCID: PMC9777057, DOI: 10.1016/j.drugalcdep.2022.109707.Peer-Reviewed Original ResearchConceptsBenzodiazepine exposureRetrospective cohort studyKaplan-Meier analysisTreatment retentionCohort studyCox regressionTreatment durationMedian treatment durationMultivariable Cox regressionCohort of patientsOpioid treatment programsOpioid use disorderLog-rank testSame-day accessDrug Administration recommendationsTreatment discontinuationUrine toxicologyMeier analysisMethadone programsUse disordersPatientsAdministration recommendationsTreatment entryTreatment programTreatment barriers
2020
All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors
Gordon K, Manhapra A, Crystal S, Dziura J, Edelman E, Skanderson M, Kerns R, Justice A, Tate J, Becker W. All-cause mortality among males living with and without HIV initiating long-term opioid therapy, and its association with opioid dose, opioid interruption and other factors. Drug And Alcohol Dependence 2020, 216: 108291. PMID: 33011662, PMCID: PMC7644145, DOI: 10.1016/j.drugalcdep.2020.108291.Peer-Reviewed Original ResearchConceptsMorphine equivalent daily doseCause mortalityLong-term opioid therapyTime-updated Cox regressionStrong dose-response relationshipUnnatural deathsEquivalent daily doseDose-response relationshipOpioid doseOpioid therapyUninfected patientsOpioid useDaily doseCox regressionMortality outcomesTherapy doseHigh doseMale veteransOverdose fatalitiesOverdose mortalityPLWHMortalityHIVPatientsDose
2019
Disagreement and Uncertainty Among Experts About how to Respond to Marijuana Use in Patients on Long-term Opioids for Chronic Pain: Results of a Delphi Study
Starrels JL, Young SR, Azari SS, Becker WC, Edelman E, Liebschutz JM, Pomeranz J, Roy P, Saini S, Merlin JS. Disagreement and Uncertainty Among Experts About how to Respond to Marijuana Use in Patients on Long-term Opioids for Chronic Pain: Results of a Delphi Study. Pain Medicine 2019, 21: 247-254. PMID: 31393585, PMCID: PMC8204879, DOI: 10.1093/pm/pnz153.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyCannabis use disorderChronic painMarijuana useLong-term opioidsInternal medicine physiciansOpioid therapyLack of evidenceOpioid managementClinical suspicionPatient factorsIndividual patientsMedicine physiciansClinician responsesOnline Delphi studyUse disordersPatientsProviders' beliefsExpert consensusClinician expertsDelphi studyFree-text responsesOpioidsNonmedical usePain
2018
“No more falling through the cracks”: A qualitative study to inform measurement of integration of care of HIV and opioid use disorder
Oldfield BJ, Muñoz N, Boshnack N, Leavitt R, McGovern MP, Villanueva M, Tetrault JM, Edelman E. “No more falling through the cracks”: A qualitative study to inform measurement of integration of care of HIV and opioid use disorder. Journal Of Substance Use And Addiction Treatment 2018, 97: 28-40. PMID: 30577897, DOI: 10.1016/j.jsat.2018.11.007.Peer-Reviewed Original ResearchConceptsOpioid use disorderIntegration of HIVUse disordersClinical staffCare of HIVCommunity-based participatory research principlesBehavioral health integrationImproved patient outcomesEvidence-based treatmentsDiverse care settingsParticipatory research principlesPrimary carePatient outcomesPatient-centered policiesCare settingsHealth integrationHIVQualitative studyStages of changeClinic leadershipCare instrumentIntegrated carePatientsBehavioral healthMeasures of qualityCommunication in the Chinese doctor–patient–family relationship: a qualitative study of expectations and experiences in a breast surgery setting
Xiao S, Wang L, Liu X, Khoshnood K, Edelman E. Communication in the Chinese doctor–patient–family relationship: a qualitative study of expectations and experiences in a breast surgery setting. The Lancet Global Health 2018, 6: s53. DOI: 10.1016/s2214-109x(18)30182-7.Peer-Reviewed Original ResearchBreast surgeonsTertiary level teaching hospitalFamily membersPatient-centered experienceHealth care experiencesSurgical patientsBreast surgeryPatient populationTeaching hospitalPatientsQualitative studyConvenience sampleSurgeryPublic healthSurgeonsDoctorsFamily relationshipsThematic analysisProvidersMedical relationshipsSemi-structured interviewsYale SchoolEmergent themesInpatientsUnmet expectations
2016
Primary Care Physicians’ Willingness to Prescribe HIV Pre-exposure Prophylaxis for People who Inject Drugs
Edelman EJ, Moore BA, Calabrese SK, Berkenblit G, Cunningham C, Patel V, Phillips K, Tetrault JM, Shah M, Fiellin DA, Blackstock O. Primary Care Physicians’ Willingness to Prescribe HIV Pre-exposure Prophylaxis for People who Inject Drugs. AIDS And Behavior 2016, 21: 1025-1033. PMID: 27896552, PMCID: PMC5344709, DOI: 10.1007/s10461-016-1612-6.Peer-Reviewed Original ResearchConceptsPrimary care physiciansPre-exposure prophylaxisCare physiciansHIV pre-exposure prophylaxisHIV risk groupMore HIVClinic patientsRisk groupsGeneral internistsPWIDAcademic general internistsPractice characteristicsDisease preventionHIVPrEPProphylaxisPatientsPhysiciansCareDrugsOnline surveyInternistsHigher willingnessLower willingnessCentral roleThe impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy
Edelman E, Gordon K, Tate J, Becker W, Bryant K, Crothers K, Gaither, Gibert C, Gordon A, Marshall B, Rodriguez‐Barradas M, Samet J, Skanderson M, Justice A, Fiellin D. The impact of prescribed opioids on CD4 cell count recovery among HIV‐infected patients newly initiating antiretroviral therapy. HIV Medicine 2016, 17: 728-739. PMID: 27186715, PMCID: PMC5053822, DOI: 10.1111/hiv.12377.Peer-Reviewed Original ResearchConceptsCD4 cell countBaseline CD4 cell countCell countPrescribed opioidsImmunosuppressive propertiesVeterans Aging Cohort Study (VACS) dataCD4 cell count recoveryAntiretroviral therapy responseCell count recoveryShort-term opioidsViral load suppressionCohort study dataOverall disease severityYear of initiationPrimary independent variableOpioid durationAntiretroviral therapyCount recoveryComorbid conditionsPharmacy dataOpioid propertiesTherapy responseOpioidsPatientsHIVPotential benefits and harms of prescription opioids in HIV
Becker W, Edelman E. Potential benefits and harms of prescription opioids in HIV. 2016, 113-122. DOI: 10.1002/9781118777374.ch11.ChaptersAntiretroviral therapyPrescription opioidsPrescription drug monitoring programsTrials of opioidsUrine toxicology testingDrug monitoring programsPeripheral nervous systemSubstance use disordersNonpharmacologic modalitiesOpioid prescribingPharmacologic treatmentOpioid analgesicsPain managementPain treatmentMedication adherenceAdequate dosesAntiretroviral adherenceTreatment agreementsSafe prescribingUse disordersNervous systemOpioidsHIVPatientsSubstance use
2014
Substance use in older HIV-infected patients
Edelman EJ, Tetrault JM, Fiellin DA. Substance use in older HIV-infected patients. Current Opinion In HIV And AIDS 2014, 9: 317-324. PMID: 24824888, PMCID: PMC4175926, DOI: 10.1097/coh.0000000000000069.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersSubstance useTreatment optionsHealth consequencesPotential treatment optionStimulant use disorderRelated health consequencesOlder HIVAntiretroviral therapyHIVPatientsBrief counselingHealth outcomesEffective interventionsComplex needsMedicationsDisordersCounseling strategiesInterventionOutcomesTobaccoLife courseOptionsTherapy