2023
Current Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review
Chuy K, Velazquez E, Lansky A, Jamil Y, Ahmad Y. Current Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101197. PMID: 39131064, PMCID: PMC11307589, DOI: 10.1016/j.jscai.2023.101197.Peer-Reviewed Original ResearchIschemic systolic heart failureSystolic heart failurePercutaneous coronary interventionHeart failureMedical therapyCoronary revascularizationBenefits of PCITrials of PCILeft ventricular systolic dysfunctionPrevalence of HFBenefit of CABGContemporary medical therapyIschemic ventricular dysfunctionCoronary artery bypassVentricular systolic dysfunctionCoronary artery diseaseIschemic heart diseaseAcute cardiac careComparative clinical effectivenessUnmet clinical needRecent revascularizationArtery bypassSystolic dysfunctionVentricular dysfunctionCoronary intervention
2019
Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus
Alenezi F, Bloomfield GS, Okeke NL, Velagapudi P, Abudaqa L, Ijioma N, Dunning A, Alajmi H, Clement ME, Shah SH, Naggie S, Velazquez EJ. Global Longitudinal Strain and Immune Status in Patients Living With Human Immunodeficiency Virus. The American Journal Of Cardiology 2019, 124: 966-971. PMID: 31371060, PMCID: PMC6887515, DOI: 10.1016/j.amjcard.2019.06.013.Peer-Reviewed Original ResearchConceptsLV ejection fractionHIV-1 RNA viral loadNormal LV ejection fractionRNA viral loadHuman immunodeficiency virusViral loadImmunodeficiency virusImmune statusGlobal longitudinal strain analysisNadir CD4 cell countPreclinical left ventricular dysfunctionDuke University Medical CenterCD4 cell countPlasma HIV RNALeft ventricular dysfunctionGlobal longitudinal strainCells/Longitudinal strain analysisUniversity Medical CenterCD4 cell count dataAbnormal GLSNadir CD4CD4 countHIV RNAVentricular dysfunction
2018
Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization
Bouabdallaoui N, Stevens SR, Doenst T, Petrie MC, Al-Attar N, Ali IS, Ambrosy AP, Barton AK, Cartier R, Cherniavsky A, Demondion P, Desvigne-Nickens P, Favaloro RR, Gradinac S, Heinisch P, Jain A, Jasinski M, Jouan J, Kalil RAK, Menicanti L, Michler RE, Rao V, Smith PK, Zembala M, Velazquez EJ, Al-Khalidi HR, Rouleau JL, Investigators F. Society of Thoracic Surgeons Risk Score and EuroSCORE-2 Appropriately Assess 30-Day Postoperative Mortality in the STICH Trial and a Contemporary Cohort of Patients With Left Ventricular Dysfunction Undergoing Surgical Revascularization. Circulation Heart Failure 2018, 11: e005531. PMID: 30571194, PMCID: PMC6309904, DOI: 10.1161/circheartfailure.118.005531.Peer-Reviewed Original ResearchConceptsPostoperative mortality riskCoronary artery bypassThoracic Surgeons risk scoreEuroScore 2Left ventricular dysfunctionContemporary cohortVentricular dysfunctionArtery bypassSTS scoreMortality riskRisk scoreSTICH patientsSTICH trialPostoperative mortalityUndergoing coronary artery bypassLeft ventricle ejection fractionVentricle ejection fractionGood c-statisticLow-risk scoresSurgical revascularizationSurvival benefitCardiac surgeryConsecutive patientsEjection fractionCC patientsVariability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Pellikka PA, She L, Holly TA, Lin G, Varadarajan P, Pai RG, Bonow RO, Pohost GM, Panza JA, Berman DS, Prior DL, Asch FM, Borges-Neto S, Grayburn P, Al-Khalidi HR, Miszalski-Jamka K, Desvigne-Nickens P, Lee KL, Velazquez EJ, Oh JK. Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. JAMA Network Open 2018, 1: e181456-e181456. PMID: 30646130, PMCID: PMC6324278, DOI: 10.1001/jamanetworkopen.2018.1456.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCoronary artery diseaseCardiovascular magnetic resonanceVentricular ejection fractionArtery diseaseCore laboratorySingle photon emissionVentricular dysfunctionEjection fractionBland-Altman plotsLVEF measurementsAssociation of LVEFGated single-photon emissionIschemic heart failureLeft ventricular dysfunctionSubset of patientsOptimal treatment strategyImaging modalitiesMulticenter diagnostic studyCardiac magnetic resonanceInternational multicenter studyLVEF dataMost patientsHeart failureSurgical treatmentThe association between blood pressure and long-term outcomes of patients with ischaemic cardiomyopathy with and without surgical revascularization: an analysis of the STICH trial
Andersson B, She L, Tan RS, Jeemon P, Mokrzycki K, Siepe M, Romanov A, Favaloro LE, Djokovic LT, Raju PK, Betlejewski P, Racine N, Ostrzycki A, Nawarawong W, Das S, Rouleau JL, Sopko G, Lee KL, Velazquez EJ, Panza JA. The association between blood pressure and long-term outcomes of patients with ischaemic cardiomyopathy with and without surgical revascularization: an analysis of the STICH trial. European Heart Journal 2018, 39: 3464-3471. PMID: 30113633, PMCID: PMC6166135, DOI: 10.1093/eurheartj/ehy438.Peer-Reviewed Original ResearchConceptsBlood pressureCoronary artery diseaseHigh blood pressureMortality outcomesSTICH trialArtery diseaseHeart failureIschemic cardiomyopathyLandmark analysisInfluence of BPLong-term mortality outcomesBP-lowering medicationsIschemic HF patientsCoronary artery bypassOutcomes of patientsBaseline blood pressureDiastolic blood pressureLower blood pressureLong-term outcomesSystolic BP valuesCABG treatmentSurgical revascularizationArtery bypassHF patientsVentricular dysfunctionSex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization
Piña IL, Zheng Q, She L, Szwed H, Lang IM, Farsky PS, Castelvecchio S, Biernat J, Paraforos A, Kosevic D, Favaloro LE, Nicolau JC, Varadarajan P, Velazquez EJ, Pai RG, Cyrille N, Lee KL, Desvigne-Nickens P. Sex Difference in Patients With Ischemic Heart Failure Undergoing Surgical Revascularization. Circulation 2018, 137: 771-780. PMID: 29459462, PMCID: PMC5896331, DOI: 10.1161/circulationaha.117.030526.Peer-Reviewed Original ResearchConceptsIschemic left ventricular dysfunctionLeft ventricular dysfunctionCause mortalityCardiovascular mortalitySTICH trialSurgical deathsVentricular dysfunctionCardiovascular hospitalizationRisk factorsKansas City Cardiomyopathy Questionnaire overall summary scoreHigher New York Heart Association classCardiac Operative Risk Evaluation scoreCoronary artery disease risk factorsNew York Heart Association classHigher body mass indexComposite of deathCoronary artery bypassIschemic heart failureDisease risk factorsPoor prognostic factorVentricular ejection fractionCoronary artery diseaseBody mass indexLong-term outcomesOverall summary scoreSix-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy
Stewart RAH, Szalewska D, Stebbins A, Al-Khalidi HR, Cleland JGH, Rynkiewicz A, Drazner MH, White HD, Mark DB, Roy A, Kosevic D, Rajda M, Jasinski M, Leng CY, Tungsubutra W, Desvigne-Nickens P, Velazquez EJ, Petrie MC. Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy. Open Heart 2018, 5: e000752. PMID: 29531766, PMCID: PMC5845417, DOI: 10.1136/openhrt-2017-000752.Peer-Reviewed Original ResearchCoronary artery bypass surgeryIschemic left ventricular dysfunctionLeft ventricular dysfunctionWalk distanceVentricular dysfunctionMedical therapyMED groupFunctional capacityNew York Heart Association classSix-minute walk distanceMin walk distanceCoronary artery bypassArtery bypass surgeryVentricular ejection fractionCoronary artery diseaseArtery bypassBypass surgeryArtery diseaseAssociation classEjection fractionIschemic cardiomyopathySurgical treatmentTreatment allocationDisease trialsPatients
2016
Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction
Samad Z, Vora AN, Dunning A, Schulte PJ, Shaw LK, Al-Enezi F, Ersboll M, McGarrah RW, Vavalle JP, Shah SH, Kisslo J, Glower D, Harrison JK, Velazquez EJ. Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction. European Heart Journal 2016, 37: 2276-2286. PMID: 26787441, PMCID: PMC5841220, DOI: 10.1093/eurheartj/ehv701.Peer-Reviewed Original ResearchConceptsAortic valve surgerySevere aortic stenosisModerate aortic stenosisAortic stenosisValve surgeryMean gradientMultivariable Cox modelVentricular systolic dysfunctionCoronary artery bypassHigh-risk cohortCurrent practice patternsArtery bypassCause mortalityEchocardiographic databaseSystolic dysfunctionVentricular dysfunctionMultivariable adjustmentTranscatheter approachMedical therapyPractice patternsBetter survivalCABGCox modelPatientsLower mortality
2015
Influence of Baseline Characteristics, Operative Conduct, and Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass Grafting Among Patients With Left Ventricular Dysfunction
Wrobel K, Stevens SR, Jones RH, Selzman CH, Lamy A, Beaver TM, Djokovic LT, Wang N, Velazquez EJ, Sopko G, Kron IL, DiMaio JM, Michler RE, Lee KL, Yii M, Leng CY, Zembala M, Rouleau JL, Daly RC, Al-Khalidi HR. Influence of Baseline Characteristics, Operative Conduct, and Postoperative Course on 30-Day Outcomes of Coronary Artery Bypass Grafting Among Patients With Left Ventricular Dysfunction. Circulation 2015, 132: 720-730. PMID: 26304663, PMCID: PMC4551105, DOI: 10.1161/circulationaha.114.014932.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCoronary artery bypassLeft ventricular dysfunctionVentricular dysfunctionArtery diseaseArtery bypassBaseline characteristicsMedical therapyOperative conductSevere left ventricular dysfunctionAtrial fibrillation/flutterSevere coronary artery diseaseLeft ventricular ejection fractionGreater operative riskSignificant preoperative predictorsCardiopulmonary bypass timeHigh-risk patientsIschemic heart failureSerious postoperative complicationsVentricular ejection fractionLeft ventricular sizeSurgical ventricular reconstructionGreater clinical benefitCABG populationSTICH trialGenetic Variants Are Not Associated with Outcome in Patients with Coronary Artery Disease and Left Ventricular Dysfunction: Results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) Trials
Feldman AM, She L, McNamara DM, Mann DL, Bristow MR, Maisel AS, Wagner DR, Andersson B, Chiariello L, Hayward CS, Hendry P, Parker JD, Racine N, Selzman CH, Senni M, Stepinska J, Zembala M, Rouleau J, Velazquez EJ, Lee KL. Genetic Variants Are Not Associated with Outcome in Patients with Coronary Artery Disease and Left Ventricular Dysfunction: Results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) Trials. Cardiology 2015, 130: 69-81. PMID: 25592552, PMCID: PMC4367125, DOI: 10.1159/000368221.Peer-Reviewed Original ResearchConceptsIschemic Heart Failure (STICH) trialHeart Failure TrialSurgical treatmentFailure TrialGenetic substudyGenetic variantsCombination of deathCoronary artery bypassHeart failure populationCoronary artery diseaseLeft ventricular reconstructionPrognostic clinical variablesΒ2-adrenergic receptor geneReceptor geneArtery bypassVentricular dysfunctionCause mortalityMultivariable adjustmentArtery diseaseCardiovascular hospitalizationMedical therapyMultivariable analysisPrognostic significanceClinical variablesVentricular reconstruction
2014
Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction
Kukulski T, She L, Racine N, Gradinac S, Panza JA, Velazquez EJ, Chan K, Petrie MC, Lee KL, Pellikka PA, Romanov A, Biernat J, Rouleau JL, Batlle C, Rogowski J, Ferrazzi P, Zembala M, Oh JK, Investigators S. Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 1312-1321. PMID: 25451487, PMCID: PMC4385741, DOI: 10.1016/j.jtcvs.2014.09.117.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesCoronary Artery BypassCoronary Artery DiseaseFemaleHeart VentriclesHumansKaplan-Meier EstimateMaleMiddle AgedPatient ReadmissionPlastic Surgery ProceduresProportional Hazards ModelsRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, RightVentricular Function, LeftVentricular Function, RightVentricular RemodelingConceptsRight ventricular dysfunctionCoronary artery bypassSurgical ventricular reconstructionSevere right ventricular dysfunctionArtery bypassVentricular dysfunctionRight ventricular functionVentricular reconstructionCause mortalityEnd pointVentricular functionClinical outcomesHigher pulmonary artery systolic pressureAdvanced left ventricular remodelingBaseline right ventricular functionPulmonary artery systolic pressureVentricular ejection fraction 35Ejection fraction 35Larger left ventriclePrimary end pointSecondary end pointsIschemic heart failureLow ejection fractionSevere mitral regurgitationCoronary artery diseaseQuality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial.
Mark DB, Knight JD, Velazquez EJ, Wasilewski J, Howlett JG, Smith PK, Spertus JA, Rajda M, Yadav R, Hamman BL, Malinowski M, Naik A, Rankin G, Harding TM, Drew LA, Desvigne-Nickens P, Anstrom KJ. Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial. Annals Of Internal Medicine 2014, 161: 392-9. PMID: 25222386, PMCID: PMC4182862, DOI: 10.7326/m13-1380.Peer-Reviewed Original ResearchConceptsIschemic left ventricular dysfunctionLeft ventricular dysfunctionCoronary artery diseaseMedical therapyVentricular dysfunctionSTICH trialArtery diseaseKansas City Cardiomyopathy Questionnaire overall summary scoreCoronary artery bypass graft surgeryGuideline-based medical therapyKansas City Cardiomyopathy QuestionnaireMultivessel coronary artery diseaseRoutine coronary artery bypassSymptomatic high-risk patientsArtery bypass graft surgeryLeft ventricular ejection fractionPrespecified secondary end pointsLife outcomesTreatment-related qualityBypass graft surgeryCoronary artery bypassMedical therapy groupSecondary end pointsHigh-risk patientsVentricular ejection fractionMetabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction
Boyle SH, Matson WR, Velazquez EJ, Samad Z, Williams RB, Sharma S, Thomas B, Wilson JL, O’Connor C, Jiang W. Metabolomics analysis reveals insights into biochemical mechanisms of mental stress-induced left ventricular dysfunction. Metabolomics 2014, 11: 571-582. PMID: 25983674, PMCID: PMC4431771, DOI: 10.1007/s11306-014-0718-y.Peer-Reviewed Original ResearchLeft ventricular dysfunctionLeft ventricular ejection fractionMental stress-induced myocardial ischemiaStress-induced left ventricular dysfunctionNormal left ventricular responseStress-induced myocardial ischemiaCoronary heart disease patientsLeft ventricular responseVentricular ejection fractionAdult CHD patientsHeart disease patientsConventional risk indicatorsVentricular dysfunctionAdverse eventsEjection fractionStable CHDVentricular responseCHD patientsDisease patientsMyocardial ischemiaLVD groupCardiovascular conditionsMental stressorsPatientsGreater riskExtent of Coronary and Myocardial Disease and Benefit From Surgical Revascularization in LV Dysfunction
Panza JA, Velazquez EJ, She L, Smith PK, Nicolau JC, Favaloro RR, Gradinac S, Chrzanowski L, Prabhakaran D, Howlett JG, Jasinski M, Hill JA, Szwed H, Larbalestier R, Desvigne-Nickens P, Jones RH, Lee KL, Rouleau JL. Extent of Coronary and Myocardial Disease and Benefit From Surgical Revascularization in LV Dysfunction. Journal Of The American College Of Cardiology 2014, 64: 553-561. PMID: 25104523, PMCID: PMC4129547, DOI: 10.1016/j.jacc.2014.04.064.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryOptimal medical therapyCoronary artery diseaseEnd-systolic volume indexEjection fractionSurgical revascularizationIschemic cardiomyopathyMedical therapyPrognostic factorsExtensive coronary artery diseaseArtery bypass graft surgeryIschemic left ventricular dysfunctionAdvanced ischemic cardiomyopathySubsequent survival benefitBypass graft surgeryHigh operative riskLeft ventricular dysfunctionGraft surgeryLV dysfunctionRevascularization TrialVentricular dysfunctionOperative riskSurvival benefitArtery diseaseMyocardial dysfunctionMyocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial
Holly TA, Bonow RO, Arnold JM, Oh JK, Varadarajan P, Pohost GM, Haddad H, Jones RH, Velazquez EJ, Birkenfeld B, Asch FM, Malinowski M, Barretto R, Kalil RA, Berman DS, Sun JL, Lee KL, Panza JA. Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: Results of the Surgical Treatment for Ischemic Heart Failure trial. Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 2677-2684.e1. PMID: 25152476, PMCID: PMC4250319, DOI: 10.1016/j.jtcvs.2014.06.090.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesCoronary Artery BypassCoronary Artery DiseaseFemaleHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPlastic Surgery ProceduresPredictive Value of TestsProportional Hazards ModelsSeverity of Illness IndexTime FactorsTissue SurvivalTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsSurgical ventricular reconstructionCoronary artery bypass graft surgeryIschemic Heart Failure (STICH) trialArtery bypass graft surgeryCoronary artery bypass surgeryBypass graft surgeryHeart Failure TrialArtery bypass surgeryLeft ventricular dysfunctionCoronary artery diseaseType of surgeryCardiac hospitalizationVentricular reconstructionVentricular dysfunctionMyocardial viabilitySurgical treatmentGraft surgeryBypass surgeryArtery diseaseFailure TrialSevere regional left ventricular dysfunctionSevere left ventricular dysfunctionRegional left ventricular dysfunctionOutcomes of patientsIschemic heart failureExercise Capacity and Mortality in Patients With Ischemic Left Ventricular Dysfunction Randomized to Coronary Artery Bypass Graft Surgery or Medical Therapy An Analysis From the STICH Trial (Surgical Treatment for Ischemic Heart Failure)
Stewart RA, Szalewska D, She L, Lee KL, Drazner MH, Lubiszewska B, Kosevic D, Ruengsakulrach P, Nicolau JC, Coutu B, Choudhary SK, Mark DB, Cleland JG, Piña IL, Velazquez EJ, Rynkiewicz A, White H. Exercise Capacity and Mortality in Patients With Ischemic Left Ventricular Dysfunction Randomized to Coronary Artery Bypass Graft Surgery or Medical Therapy An Analysis From the STICH Trial (Surgical Treatment for Ischemic Heart Failure). JACC Heart Failure 2014, 2: 335-343. PMID: 25023813, PMCID: PMC4127151, DOI: 10.1016/j.jchf.2014.02.009.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryIschemic left ventricular dysfunctionLeft ventricular dysfunctionArtery bypass graft surgeryBypass graft surgeryPoor exercise capacityExercise capacityMedical therapyVentricular dysfunctionSTICH trialGraft surgeryBetter exercise capacityWalk testMedical managementPrognostic significanceTreatment allocationPhysical activityPatientsEarly riskHigh mortalityMortalityTherapyDysfunctionSurgeryTrials
2013
Prognostic Significance of Biomarkers in Predicting Outcome in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Feldman AM, Mann DL, She L, Bristow MR, Maisel AS, McNamara DM, Walsh R, Lee DL, Wos S, Lang I, Wells G, Drazner MH, Schmedtje JF, Pauly DF, Sueta CA, Di Maio M, Kron IL, Velazquez EJ, Lee KL. Prognostic Significance of Biomarkers in Predicting Outcome in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. Circulation Heart Failure 2013, 6: 461-472. PMID: 23584092, PMCID: PMC3905743, DOI: 10.1161/circheartfailure.112.000185.Peer-Reviewed Original ResearchConceptsCoronary artery bypassPrimary end pointCoronary artery diseaseIndependent prognostic informationArtery bypassMultivariable analysisPrognostic informationSTNFR-1Artery diseaseClinical factorsPlasma levelsUnivariate analysisIschemic Heart Failure (STICH) trialEnd pointSoluble tumor necrosisHeart Failure TrialLeft ventricular reconstructionPrimary outcome variableNet reclassification improvementAbility of biomarkersSubstudy patientsVentricular dysfunctionCardiac hospitalizationBiomarker substudyHeart failureInducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Panza JA, Holly TA, Asch FM, She L, Pellikka PA, Velazquez EJ, Lee KL, Borges-Neto S, Farsky PS, Jones RH, Berman DS, Bonow RO. Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction. Journal Of The American College Of Cardiology 2013, 61: 1860-1870. PMID: 23500234, PMCID: PMC3755503, DOI: 10.1016/j.jacc.2013.02.014.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseDobutamine stress echocardiogramLV ejection fractionInducible myocardial ischemiaEjection fractionMedical therapyMyocardial ischemiaCause mortalityVentricular dysfunctionArtery diseaseClinical endpointsMultivessel coronary artery diseaseOptimal medical therapyRadionuclide stress testsCoronary artery bypassSevere LV dysfunctionLeft ventricular dysfunctionStress-induced ischemiaPrevious myocardial infarctionSummed difference scoreStress testingRNS testingSTICH patientsSTICH trialArtery bypass
2012
Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial
Deja MA, Grayburn PA, Sun B, Rao V, She L, Krejca M, Jain AR, Chua Y, Daly R, Senni M, Mokrzycki K, Menicanti L, Oh JK, Michler R, Wróbel K, Lamy A, Velazquez EJ, Lee KL, Jones RH. Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial. Circulation 2012, 125: 2639-2648. PMID: 22553307, PMCID: PMC3776601, DOI: 10.1161/circulationaha.111.072256.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationMild mitral regurgitationMitral regurgitationMitral valve repairTrace mitral regurgitationMitral surgeryMedical therapyValve repairIschemic Heart Failure (STICH) trialCoronary artery bypassHeart Failure TrialPrimary end pointLeft ventricular dysfunctionCoronary artery diseaseModerate mitral regurgitationBaseline prognostic variablesIschemic mitral regurgitationArtery bypassRandomized patientsVentricular dysfunctionHazard ratioArtery diseaseEjection fractionMedical armSurgical treatment
2011
Response to Letter Regarding Article, “Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both”
Pouleur A, Barkoudah E, Uno H, Skali H, Finn P, Zelenkofske S, Belenkov Y, Mareev V, Velazquez E, Rouleau J, Maggioni A, Køber L, Califf R, McMurray J, Pfeffer M, Solomon S. Response to Letter Regarding Article, “Pathogenesis of Sudden Unexpected Death in a Clinical Trial of Patients With Myocardial Infarction and Left Ventricular Dysfunction, Heart Failure, or Both”. Circulation 2011, 123: e586-e587. DOI: 10.1161/circulationaha.111.021600.Commentaries, Editorials and Letters