2020
Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography
Daubert MA, Sivak J, Dunning A, Douglas PS, Coyne B, Wang TY, Mark DB, Velazquez EJ. Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography. JAMA Internal Medicine 2020, 180: 494-502. PMID: 31985749, PMCID: PMC6990669, DOI: 10.1001/jamainternmed.2019.6958.Peer-Reviewed Original ResearchConceptsNormal stress echocardiographyComposite end pointStress echoExercise electrocardiographyStress echocardiographyMyocardial infarctionDownstream testingEnd pointDuke University Medical CenterExercise stress echoNegative exercise ECGStress ECG findingsAdverse cardiac eventsIncremental prognostic valueObservational cohort studyAdverse clinical eventsCoronary artery diseaseIndividual adverse eventsPopulation of patientsUniversity Medical CenterImaging resultsCoronary revascularizationAdverse eventsCardiac eventsCohort study
2019
Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012
Kelly JP, Andonian BJ, Patel MJ, Huang Z, Shaw LK, McGarrah RW, Borges-Neto S, Velazquez EJ, Kraus WE. Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012. American Heart Journal 2019, 210: 88-97. PMID: 30743212, PMCID: PMC6441626, DOI: 10.1016/j.ahj.2019.01.001.Peer-Reviewed Original ResearchConceptsExercise treadmill testingCardiorespiratory fitnessTreadmill testingMetabolic equivalentsSingle academic medical centerStandard Bruce protocolMaximal treadmill speedDuke University HospitalAcademic medical centerBaseline comorbiditiesEligible patientsNuclear perfusionBruce protocolClinical outcomesStress echocardiographyUniversity HospitalMedical CenterMedical care environmentClinical practiceRamp protocolMaximal exertionPatientsTreadmill speedPowerful predictorCare environment
2018
Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation
Minter S, Armour A, Tinnemore A, Strub K, Crowley AL, Bloomfield GS, Alexander JH, Douglas PS, Kisslo JA, Velazquez EJ, Samad Z. Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation. The International Journal Of Cardiovascular Imaging 2018, 34: 1725-1730. PMID: 30128849, DOI: 10.1007/s10554-018-1389-y.Peer-Reviewed Original ResearchConceptsStress echocardiography studyObstructive coronary diseaseGold standardWall motion abnormalitiesCoronary angiography dataCoronary diseaseStress echocardiographyEchocardiography studyHard outcomesMotion abnormalitiesStress echoSurvey participants' responsesClinical readsEchocardiographic interpretationImperfect gold standardIndependent consensusParticipants' responsesEchocardiographic imagesAngiography dataEchocardiography interpretationValidation surveyParticipantsEchocardiographyConsensusFirst survey
2014
Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy
Khouri MG, Hornsby WE, Risum N, Velazquez EJ, Thomas S, Lane A, Scott JM, Koelwyn GJ, Herndon JE, Mackey JR, Douglas PS, Jones LW. Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy. Breast Cancer Research And Treatment 2014, 143: 531-539. PMID: 24390149, PMCID: PMC4521213, DOI: 10.1007/s10549-013-2818-1.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainBreast cancer patientsSubclinical cardiac dysfunctionCardiac dysfunctionCancer patientsCardiac indexStress echocardiographyEarly breast cancer patientsLongitudinal strainVentricular ejection fraction assessmentLeft ventricular ejection fraction assessmentAdult oncology settingsPost-exercise increaseEarly breast cancerLeft ventricular functionSex-matched controlsSpeckle tracking echocardiographyEjection fraction assessmentSimilar LVEFAdjuvant therapyEchocardiographic parametersCardiopulmonary exerciseAsymptomatic womenVentricular functionCardiopulmonary function
2004
Usefulness of myocardial viability or ischemia in predicting long-term survival for patients with severe left ventricular dysfunction undergoing revascularization
Liao L, Cabell CH, Jollis JG, Velazquez EJ, Smith WT, Anstrom KJ, Pappas PA, Ryan T, Kisslo JA, Landolfo CK. Usefulness of myocardial viability or ischemia in predicting long-term survival for patients with severe left ventricular dysfunction undergoing revascularization. The American Journal Of Cardiology 2004, 93: 1275-1279. PMID: 15135703, DOI: 10.1016/j.amjcard.2004.01.071.Peer-Reviewed Original ResearchConceptsSevere left ventricular dysfunctionLeft ventricular dysfunctionVentricular dysfunctionDobutamine stress echocardiographySignificant survival advantageLong-term survivalCoronary diseaseStress echocardiographyViable myocardiumMyocardial viabilityPrognostic powerSurvival advantagePatientsRevascularizationDysfunctionEchocardiographyIschemiaMyocardiumDiseaseMonths