2017
Prevalence and Outcomes of Left‐Sided Valvular Heart Disease Associated With Chronic Kidney Disease
Samad Z, Sivak JA, Phelan M, Schulte PJ, Patel U, Velazquez EJ. Prevalence and Outcomes of Left‐Sided Valvular Heart Disease Associated With Chronic Kidney Disease. Journal Of The American Heart Association 2017, 6: e006044. PMID: 29021274, PMCID: PMC5721834, DOI: 10.1161/jaha.117.006044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAortic ValveAortic Valve StenosisComorbidityDatabases, FactualEchocardiographyFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateKidneyMaleMiddle AgedMitral ValveMitral Valve InsufficiencyNorth CarolinaPrevalencePrognosisProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsConceptsChronic kidney diseaseFive-year survival estimatesNon-CKD patientsCKD patientsMitral regurgitationMR severityKidney diseaseSurvival estimatesCoronary artery bypassGlomerular filtration ratePercutaneous coronary interventionSevere mitral regurgitationValvular heart diseaseSerum creatinine valuesAdverse prognostic markerRegurgitant valve lesionsIndex echocardiogramSevere ASArtery bypassIntervention patientsValve lesionsValve surgeryCoronary interventionHazard ratioHeart failure
2015
Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction
Samad Z, Shaw LK, Phelan M, Ersboll M, Risum N, Al-Khalidi HR, Glower DD, Milano CA, Alexander JH, O'Connor CM, Wang A, Velazquez EJ. Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction. European Heart Journal 2015, 36: 2733-2741. PMID: 26233850, DOI: 10.1093/eurheartj/ehv343.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSevere mitral regurgitationEvent-free survival benefitHigher event-free survivalSevere functional mitral regurgitationMV surgerySevere LV dysfunctionEvent-free survivalOutcomes of patientsMitral regurgitationFunctional mitral regurgitationIPW adjustmentSystolic dysfunctionLV dysfunctionSurvival benefitEntire cohortTreatment strategiesSevere left ventricular systolic dysfunctionCoronary artery bypass graft surgeryMultivariable Cox proportional hazards modelsSevere left ventricular dysfunctionArtery bypass graft surgeryLeft ventricular systolic dysfunctionCox proportional hazards modelIsolated MV surgery
2014
Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction
Kukulski T, She L, Racine N, Gradinac S, Panza JA, Velazquez EJ, Chan K, Petrie MC, Lee KL, Pellikka PA, Romanov A, Biernat J, Rouleau JL, Batlle C, Rogowski J, Ferrazzi P, Zembala M, Oh JK, Investigators S. Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: 1312-1321. PMID: 25451487, PMCID: PMC4385741, DOI: 10.1016/j.jtcvs.2014.09.117.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesCoronary Artery BypassCoronary Artery DiseaseFemaleHeart VentriclesHumansKaplan-Meier EstimateMaleMiddle AgedPatient ReadmissionPlastic Surgery ProceduresProportional Hazards ModelsRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, RightVentricular Function, LeftVentricular Function, RightVentricular RemodelingConceptsRight ventricular dysfunctionCoronary artery bypassSurgical ventricular reconstructionSevere right ventricular dysfunctionArtery bypassVentricular dysfunctionRight ventricular functionVentricular reconstructionCause mortalityEnd pointVentricular functionClinical outcomesHigher pulmonary artery systolic pressureAdvanced left ventricular remodelingBaseline right ventricular functionPulmonary artery systolic pressureVentricular ejection fraction 35Ejection fraction 35Larger left ventriclePrimary end pointSecondary end pointsIschemic heart failureLow ejection fractionSevere mitral regurgitationCoronary artery disease
2012
Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial
Deja MA, Grayburn PA, Sun B, Rao V, She L, Krejca M, Jain AR, Chua Y, Daly R, Senni M, Mokrzycki K, Menicanti L, Oh JK, Michler R, Wróbel K, Lamy A, Velazquez EJ, Lee KL, Jones RH. Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial. Circulation 2012, 125: 2639-2648. PMID: 22553307, PMCID: PMC3776601, DOI: 10.1161/circulationaha.111.072256.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationMild mitral regurgitationMitral regurgitationMitral valve repairTrace mitral regurgitationMitral surgeryMedical therapyValve repairIschemic Heart Failure (STICH) trialCoronary artery bypassHeart Failure TrialPrimary end pointLeft ventricular dysfunctionCoronary artery diseaseModerate mitral regurgitationBaseline prognostic variablesIschemic mitral regurgitationArtery bypassRandomized patientsVentricular dysfunctionHazard ratioArtery diseaseEjection fractionMedical armSurgical treatmentMechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction
Meris A, Amigoni M, Verma A, Thune JJ, Køber L, Velazquez E, McMurray JJ, Pfeffer MA, Califf R, Levine RA, Solomon SD, Investigators V. Mechanisms and Predictors of Mitral Regurgitation after High-Risk Myocardial Infarction. Journal Of The American Society Of Echocardiography 2012, 25: 535-542. PMID: 22305962, PMCID: PMC3501447, DOI: 10.1016/j.echo.2012.01.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngiotensin-Converting Enzyme InhibitorsCaptoprilDisease ProgressionEchocardiography, Doppler, ColorElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral Valve InsufficiencyMonitoring, PhysiologicMultivariate AnalysisMyocardial InfarctionPredictive Value of TestsProspective StudiesReference ValuesReproducibility of ResultsRisk AssessmentROC CurveSeverity of Illness IndexSex FactorsStatistics, NonparametricStroke VolumeTetrazolesTime FactorsValineValsartanVentricular Dysfunction, LeftVentricular RemodelingConceptsHigh-risk myocardial infarctionBaseline mitral regurgitationMitral regurgitationMyocardial infarctionAtrial sizeIndependent predictorsCoaptation depthProgression of MRMitral valve deformationStructural valve diseaseSevere mitral regurgitationFunctional mitral regurgitationIschemic mitral regurgitationGood-quality echocardiogramsMitral annular areaMitral tentingMR degreeLV dysfunctionTenting areaBaseline characteristicsDiastolic functionHeart failureValve diseaseLV remodelingVentricular remodeling
2010
Impact of early surgery on survival of patients with severe mitral regurgitation
Samad Z, Kaul P, Shaw LK, Glower DD, Velazquez EJ, Douglas PS, Jollis JG. Impact of early surgery on survival of patients with severe mitral regurgitation. Heart 2010, 97: 221. PMID: 21071750, DOI: 10.1136/hrt.2010.202432.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationDegenerative mitral regurgitationEarly surgery groupLate surgery groupEarly surgeryMitral regurgitationSurgery groupLate surgeryGuideline indicationsOptimal timingValve diseaseMV repairAdjusted Cox regression modelCongenital mitral valve diseaseValve repair/replacementSevere degenerative mitral regurgitationACC/AHA guideline recommendationsSevere valve diseaseSurvival of patientsTiming of surgeryMitral valve diseaseCox regression modelLong-term survivalEarly referralCoronary disease