2016
Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy
Velazquez EJ, Lee KL, Jones RH, Al-Khalidi HR, Hill JA, Panza JA, Michler RE, Bonow RO, Doenst T, Petrie MC, Oh JK, She L, Moore VL, Desvigne-Nickens P, Sopko G, Rouleau JL. Coronary-Artery Bypass Surgery in Patients with Ischemic Cardiomyopathy. New England Journal Of Medicine 2016, 374: 1511-1520. PMID: 27040723, PMCID: PMC4938005, DOI: 10.1056/nejmoa1602001.Peer-Reviewed Original ResearchConceptsMedical therapy groupCardiovascular causesCoronary artery diseaseMedical therapyCABG groupArtery diseaseIschemic cardiomyopathySevere left ventricular systolic dysfunctionGuideline-directed medical therapyLeft ventricular systolic dysfunctionMajor secondary outcomesCoronary artery bypassPrimary outcome eventVentricular systolic dysfunctionArtery bypass surgeryCohort of patientsRate of deathSystolic dysfunctionBypass surgeryMedian durationSecondary outcomesSurvival benefitEjection fractionHeart failurePrimary outcome
2011
Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction
Velazquez EJ, Lee KL, Deja MA, Jain A, Sopko G, Marchenko A, Ali IS, Pohost G, Gradinac S, Abraham WT, Yii M, Prabhakaran D, Szwed H, Ferrazzi P, Petrie MC, O'Connor CM, Panchavinnin P, She L, Bonow RO, Rankin GR, Jones RH, Rouleau JL. Coronary-Artery Bypass Surgery in Patients with Left Ventricular Dysfunction. New England Journal Of Medicine 2011, 364: 1607-1616. PMID: 21463150, PMCID: PMC3415273, DOI: 10.1056/nejmoa1100356.Peer-Reviewed Original ResearchConceptsMedical therapy groupCardiovascular causesCoronary artery diseaseMedical therapyCABG groupRate of deathArtery diseasePrimary outcomeMajor secondary outcomesCoronary artery bypassPrimary end pointArtery bypass surgeryLeft ventricular dysfunctionTreatment of patientsVentricular dysfunctionBypass surgerySecondary outcomesEjection fractionHeart failureCABGPatientsTherapyEnd pointHospitalizationDeath
2009
Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction
Jones RH, Velazquez EJ, Michler RE, Sopko G, Oh JK, O'Connor CM, Hill JA, Menicanti L, Sadowski Z, Desvigne-Nickens P, Rouleau JL, Lee KL. Coronary Bypass Surgery with or without Surgical Ventricular Reconstruction. New England Journal Of Medicine 2009, 360: 1705-1717. PMID: 19329820, PMCID: PMC3265934, DOI: 10.1056/nejmoa0900559.Peer-Reviewed Original ResearchConceptsSurgical ventricular reconstructionCoronary artery diseaseVentricular reconstructionRate of deathCardiac causesLeft ventricular volumeArtery diseasePrimary outcomeVentricular volumeEnd-systolic volume indexComposite of deathCoronary artery bypassCoronary bypass surgeryLeft ventricular dysfunctionVentricular dysfunctionBypass surgeryCardiac symptomsEjection fractionHeart failureCABGStudy groupPatientsVolume indexHospitalizationAnatomical changes