2011
Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both
Shah AM, Hung CL, Shin SH, Skali H, Verma A, Ghali JK, Køber L, Velazquez EJ, Rouleau JL, McMurray JJ, Pfeffer MA, Solomon SD. Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. American Heart Journal 2011, 162: 685-691. PMID: 21982661, DOI: 10.1016/j.ahj.2011.07.015.Peer-Reviewed Original ResearchConceptsLV mass indexRisk of deathRelative wall thicknessDiabetic patientsEjection fractionMass indexHigh riskBaseline LV mass indexLeft ventricular systolic dysfunctionHigher LV mass indexHeart failure post-myocardial infarctionVALIANT Echo studyAtrial volume indexVentricular systolic dysfunctionAge-adjusted modelsQuantitative echocardiographic analysisPost-myocardial infarctionHF hospitalizationLong-term elevationNondiabetic patientsConcentric remodelingSystolic dysfunctionAtrial enlargementHeart failureClinical outcomes
2006
Use of Valsartan in Post-Myocardial Infarction and Heart Failure Patients
Liu PP, Maggioni A, Velazquez EJ. Use of Valsartan in Post-Myocardial Infarction and Heart Failure Patients. Journal Of The Renin-Angiotensin-Aldosterone System 2006, 7: s19-s22. PMID: 16986231, DOI: 10.3317/jraas.2006.019.Peer-Reviewed Original ResearchConceptsAng II receptor blockersHeart failureLV dysfunctionMyocardial infarctionStrong therapeutic rationaleUse of valsartanII receptor blockersLeft ventricular dysfunctionHeart failure patientsPost-MI patientsMain effector mechanismPost-myocardial infarctionLarge-scale trialsRAAS blockadeAldosterone systemReceptor blockersVentricular dysfunctionAssociated morbidityFailure patientsFrequent complicationSuch patientsACE inhibitorsSignificant morbiditySuch therapyDisease progression
2005
Therapies to prevent heart failure post-myocardial infarction
Thomas KL, Velazquez EJ. Therapies to prevent heart failure post-myocardial infarction. Current Heart Failure Reports 2005, 2: 174-182. PMID: 16332310, DOI: 10.1007/bf02696647.Peer-Reviewed Original ResearchConceptsPost-MI heart failureHeart failureMyocardial infarctionPresence of HFHeart failure post-myocardial infarctionEvidence-based medicationsMortality of patientsOutcomes of patientsVentricular systolic dysfunctionLower blood pressureTreatment of patientsAcute myocardial infarctionPost-myocardial infarctionKillip classSystolic dysfunctionCommon complicationBlood pressureClinical factorsRevascularization proceduresInfarct sizePoor prognosisPatient populationMale genderPost-MIRisk factors