2014
Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study
Jiang W, Boyle SH, Ortel TL, Samad Z, Velazquez EJ, Harrison RW, Wilson J, Kuhn C, Williams RB, O’Connor C, Becker RC. Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study. American Heart Journal 2014, 169: 496-507.e1. PMID: 25819856, PMCID: PMC4382806, DOI: 10.1016/j.ahj.2014.12.002.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaIschemic heart diseaseSerotonin transporter expressionMyocardial ischemiaPlatelet aggregationPlatelet hyperactivityNormal left ventricular responseStable ischemic heart diseaseStress-induced myocardial ischemiaMental stressTransporter expressionAcute coronary syndromeLeft ventricular responseMental stress testMental stress testingCombination of serotoninEligible patientsCardiovascular eventsCardiovascular prognosisCoronary syndromeVentricular responsePlatelet activityHeart diseaseTreatment studiesIschemiaImpaired Resting Myocardial Annular Velocities Are Independently Associated With Mental Stress–Induced Ischemia in Coronary Heart Disease
Ersbøll M, Al Enezi F, Samad Z, Sedberry B, Boyle SH, O’Connor C, Jiang W, Velazquez EJ, Investigators R. Impaired Resting Myocardial Annular Velocities Are Independently Associated With Mental Stress–Induced Ischemia in Coronary Heart Disease. JACC Cardiovascular Imaging 2014, 7: 351-361. PMID: 24631512, PMCID: PMC3992174, DOI: 10.1016/j.jcmg.2013.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedChi-Square DistributionEchocardiography, DopplerEchocardiography, StressExercise TestFemaleHumansLogistic ModelsMaleMiddle AgedMyocardial ContractionMyocardial IschemiaOdds RatioPredictive Value of TestsRandomized Controlled Trials as TopicRisk FactorsStress, PsychologicalStroke VolumeVentricular Function, LeftConceptsMental stress-induced ischemiaStress-induced myocardial ischemiaLeft ventricular ejection fractionTissue Doppler myocardial velocitiesVentricular ejection fractionMental stress testMyocardial velocitiesMyocardial ischemiaEjection fractionHeart diseaseConventional exercise stress testingWall motion index scoreIschemic ST-segment changesMyocardial tissue Doppler velocitiesRegional wall motion abnormalitiesPreclinical cardiac dysfunctionStress-induced ischemiaCoronary artery diseaseExercise stress testingTissue Doppler velocitiesCoronary heart diseaseLate diastolic velocityST-segment changesWall motion abnormalitiesStress–Induced Ischemia
2013
Depressive Symptoms and Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease
Boyle SH, Samad Z, Becker RC, Williams R, Kuhn C, Ortel TL, Kuchibhatla M, Prybol K, Rogers J, O’Connor C, Velazquez EJ, Jiang W. Depressive Symptoms and Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease. Psychosomatic Medicine 2013, 75: 822-831. PMID: 24163385, PMCID: PMC4378828, DOI: 10.1097/psy.0b013e3182a893ae.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaCoronary heart diseaseLeft ventricular ejection fractionVentricular ejection fractionDepressive symptomsMyocardial ischemiaEjection fractionHeart diseaseMental Stress–Induced Myocardial IschemiaStress-induced myocardial ischemiaIschemic ST-segment changesBeck Depression Inventory-II scoresΒ-blocker withdrawalEpidemiologic Studies Depression ScaleFuture cardiovascular eventsMental stress testTreadmill exercise testST-segment changesWall motion abnormalitiesBeck Depression Inventory-IICardiovascular eventsII scoreTransthoracic echocardiographyAdult patientsUnadjusted analysesPrevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease
Jiang W, Samad Z, Boyle S, Becker RC, Williams R, Kuhn C, Ortel TL, Rogers J, Kuchibhatla M, O'Connor C, Velazquez EJ. Prevalence and Clinical Characteristics of Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Heart Disease. Journal Of The American College Of Cardiology 2013, 61: 714-722. PMID: 23410543, PMCID: PMC3913125, DOI: 10.1016/j.jacc.2012.11.037.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaCoronary heart diseaseMental stress-induced myocardial ischemiaStable coronary heart diseaseStress-induced myocardial ischemiaExercise-induced ischemiaHeart diseaseMyocardial ischemiaClinical characteristicsHigh riskMental Stress–Induced Myocardial IschemiaExercise-induced myocardial ischemiaVentricular ejection fraction reductionRegional wall motion abnormalitiesEjection fraction reductionST-segment depressionMental stress testWall motion abnormalitiesUnmarried menEligible patientsPoor prognosisMotion abnormalitiesRisk factorsExercise test