2019
Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy
Panza JA, Ellis AM, Al-Khalidi HR, Holly TA, Berman DS, Oh JK, Pohost GM, Sopko G, Chrzanowski L, Mark DB, Kukulski T, Favaloro LE, Maurer G, Farsky PS, Tan RS, Asch FM, Velazquez EJ, Rouleau JL, Lee KL, Bonow RO. Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy. New England Journal Of Medicine 2019, 381: 739-748. PMID: 31433921, PMCID: PMC6814246, DOI: 10.1056/nejmoa1807365.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassEchocardiography, StressFemaleFollow-Up StudiesHeartHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedMyocardial IschemiaProportional Hazards ModelsProspective StudiesStroke VolumeTomography, Emission-Computed, Single-PhotonTreatment OutcomeVentricular Function, LeftConceptsLeft ventricular ejection fractionVentricular ejection fractionMedical therapyEjection fractionMyocardial viabilityIschemic cardiomyopathyLeft ventricular systolic functionGoals of revascularizationCoronary artery bypassPrimary end pointVentricular systolic functionCoronary artery diseaseLeft ventricular functionLong-term outcomesLong-term survivalSurgical revascularizationDobutamine echocardiographyMedian durationSystolic functionArtery diseaseVentricular functionViable myocardiumLong-term benefitsLower incidenceCABG
2018
Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block
Sze E, Samad Z, Dunning A, Campbell KB, Loring Z, Atwater BD, Chiswell K, Kisslo JA, Velazquez EJ, Daubert JP. Impaired Recovery of Left Ventricular Function in Patients With Cardiomyopathy and Left Bundle Branch Block. Journal Of The American College Of Cardiology 2018, 71: 306-317. PMID: 29348023, PMCID: PMC8352572, DOI: 10.1016/j.jacc.2017.11.020.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyLeft bundle branch blockCardiac resynchronization therapyWide QRS durationBundle branch blockQRS durationLVEF improvementQRS morphologyReduced LVEFBranch blockLeft ventricular ejection fraction improvementVentricular ejection fraction improvementEjection fraction improvementMean LVEF improvementNarrow QRS durationSevere valve diseaseFirst-line therapyHeart failure hospitalizationLeft ventricular functionVentricular assist deviceBaseline electrocardiographyFailure hospitalizationCombined endpointSignificant comorbiditiesResynchronization therapy
2015
Influence of QRS infarct score and QRS duration prior to transcatheter aortic valve replacement on follow-up left ventricular end systolic volume in patients with new persistent left bundle branch block
Hannink LG, Wagner GS, Kisslo J, Alenezi FA, Shaw LK, Hofmann P, Zusterzeel R, Phelan M, Velazquez EJ, Gorgels AP. Influence of QRS infarct score and QRS duration prior to transcatheter aortic valve replacement on follow-up left ventricular end systolic volume in patients with new persistent left bundle branch block. Journal Of Electrocardiology 2015, 48: 637-642. PMID: 25959263, DOI: 10.1016/j.jelectrocard.2015.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAortic Valve StenosisBundle-Branch BlockDiagnosis, Computer-AssistedEchocardiographyElectrocardiographyFemaleFollow-Up StudiesHumansMalePrognosisReproducibility of ResultsRetrospective StudiesRisk AssessmentSensitivity and SpecificityStroke VolumeTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsLeft bundle branch blockTranscatheter aortic valve replacementPersistent left bundle branch blockVentricular end-systolic volumeAortic valve replacementBundle branch blockEnd-systolic volumeQRS durationInfarct scoreValve replacementVentricular functionBranch blockNew-onset left bundle branch blockLeft ventricular end-systolic volumeNew left bundle branch blockLeft ventricular functionLarger study populationStrict inclusion criteriaSuch predictive valueQRS scoreSystolic volumeInclusion criteriaStudy populationCardiac conditionsPredictive value
2014
Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy
Khouri MG, Hornsby WE, Risum N, Velazquez EJ, Thomas S, Lane A, Scott JM, Koelwyn GJ, Herndon JE, Mackey JR, Douglas PS, Jones LW. Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy. Breast Cancer Research And Treatment 2014, 143: 531-539. PMID: 24390149, PMCID: PMC4521213, DOI: 10.1007/s10549-013-2818-1.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainBreast cancer patientsSubclinical cardiac dysfunctionCardiac dysfunctionCancer patientsCardiac indexStress echocardiographyEarly breast cancer patientsLongitudinal strainVentricular ejection fraction assessmentLeft ventricular ejection fraction assessmentAdult oncology settingsPost-exercise increaseEarly breast cancerLeft ventricular functionSex-matched controlsSpeckle tracking echocardiographyEjection fraction assessmentSimilar LVEFAdjuvant therapyEchocardiographic parametersCardiopulmonary exerciseAsymptomatic womenVentricular functionCardiopulmonary function
2013
Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction
Wang N, Shah A, Querejeta G, Gupta D, Velazquez E, Califf R, Mcmurray J, Pfeffer M, Solomon S. Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction. European Heart Journal 2013, 34: p662. DOI: 10.1093/eurheartj/eht307.p662.Peer-Reviewed Original ResearchWall motion scoreLV ejection fractionHeart failureLV dysfunctionRegional cardiac functionLongitudinal strainEjection fractionClinical outcomesCardiac functionMultivariate Cox proportional hazards modelCox proportional hazards modelPost-myocardial infarction patientsLV wall motion scoreAbnormal wall motion scoreRegional cardiac dysfunctionLeft ventricular dysfunctionLeft ventricular functionMyocardial infarction patientsSpeckle tracking echocardiographySegmental longitudinal strainRegional longitudinal strainProportional hazards modelRegional myocardial functionPeak longitudinal strainNormal reference values
2012
Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy
Oh JK, Velazquez EJ, Menicanti L, Pohost GM, Bonow RO, Lin G, Hellkamp AS, Ferrazzi P, Wos S, Rao V, Berman D, Bochenek A, Cherniavsky A, Rogowski J, Rouleau JL, Lee KL, Investigators O. Influence of baseline left ventricular function on the clinical outcome of surgical ventricular reconstruction in patients with ischaemic cardiomyopathy. European Heart Journal 2012, 34: 39-47. PMID: 22584648, PMCID: PMC3533917, DOI: 10.1093/eurheartj/ehs021.Peer-Reviewed Original ResearchConceptsEnd-systolic volume indexSurgical ventricular reconstructionRegional wall motion abnormalitiesWall motion abnormalitiesEjection fractionBetter LVEFIschemic cardiomyopathyVentricular reconstructionMotion abnormalitiesLV end-systolic volume indexMedian end-systolic volume indexBaseline left ventricular functionIschemic Heart Failure (STICH) trialEnd-diastolic volume indexVolume indexBaseline LV functionCoronary artery bypassHeart Failure TrialLeft ventricular functionClinical trial registrationLeft ventricular function parametersLV global functionVentricular function parametersCardiovascular magnetic resonanceML/m2
2011
Incremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction
Verma A, Pfeffer MA, Skali H, Rouleau J, Maggioni A, McMurray JJ, Califf RM, Velazquez EJ, Solomon SD. Incremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction. American Heart Journal 2011, 161: 1156-1162. PMID: 21641363, DOI: 10.1016/j.ahj.2011.03.024.Peer-Reviewed Original ResearchConceptsLV ejection fractionHigh-risk myocardial infarctionOutcome of deathHeart failureEchocardiographic measuresMyocardial infarctionEchocardiographic assessmentEjection fractionPrognostic valueClinical variablesClinical assessmentPredictive valueRight ventricular fractional area changeMultivariable proportional hazards modelsVentricular fractional area changeLeft ventricular ejection fractionMinimal prognostic valueAtrial volume indexIncremental prognostic valuePredictors of deathVentricular mass indexVentricular ejection fractionLeft ventricular functionPrediction of deathImportant prognostic information
2009
Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: Results from the Surgical Treatment for Ischemic Heart Failure trial
Mark DB, Knight JD, Velazquez EJ, Howlett JG, Spertus JA, Djokovic LT, Harding TM, Rankin GR, Drew LA, Szygula-Jurkiewicz B, Adlbrecht C, Anstrom KJ, Investigators F. Quality of life and economic outcomes with surgical ventricular reconstruction in ischemic heart failure: Results from the Surgical Treatment for Ischemic Heart Failure trial. American Heart Journal 2009, 157: 837-844.e3. PMID: 19376309, PMCID: PMC2694042, DOI: 10.1016/j.ahj.2009.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery BypassFemaleFollow-Up StudiesHealth Care CostsHeart FailureHeart VentriclesHumansMaleMiddle AgedMyocardial IschemiaPlastic Surgery ProceduresQuality of LifeRetrospective StudiesStroke VolumeSurveys and QuestionnairesTreatment OutcomeUnited StatesVentricular Function, LeftConceptsCoronary artery bypass graft surgerySurgical ventricular reconstructionIschemic heart failureQuality of lifeHeart failureVentricular reconstructionQOL measuresIschemic Heart Failure (STICH) trialKansas City Cardiomyopathy QuestionnaireTotal index hospitalization costsArtery bypass graft surgeryLeft ventricular ejection fractionBetter QOLIndex hospitalization costsBypass graft surgeryHeart failure symptomsHeart Failure TrialVentricular ejection fractionLeft ventricular functionHealth care costsTreatment-related differencesGraft surgeryEjection fractionSurgical treatmentVentricular function
2006
Comparison of Regional Versus Global Assessment of Left Ventricular Function in Patients with Left Ventricular Dysfunction, Heart Failure, or Both After Myocardial Infarction: The Valsartan in Acute Myocardial Infarction Echocardiographic Study
Thune JJ, Køber L, Pfeffer MA, Skali H, Anavekar NS, Bourgoun M, Ghali JK, Arnold JM, Velazquez EJ, Solomon SD. Comparison of Regional Versus Global Assessment of Left Ventricular Function in Patients with Left Ventricular Dysfunction, Heart Failure, or Both After Myocardial Infarction: The Valsartan in Acute Myocardial Infarction Echocardiographic Study. Journal Of The American Society Of Echocardiography 2006, 19: 1462-1465. PMID: 17138030, DOI: 10.1016/j.echo.2006.05.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsComorbidityEchocardiographyFemaleHeart FailureHumansInternationalityMaleMiddle AgedMyocardial InfarctionPrevalencePrognosisReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityStroke VolumeTetrazolesValineValsartanVentricular Dysfunction, LeftConceptsWall motion indexMyocardial infarctionHeart failureLV dysfunctionEjection fractionIndependent predictorsGlobal assessmentLeft ventricular dysfunctionLV systolic functionVentricular ejection fractionAdditional prognostic informationLeft ventricular functionAcute myocardial infarctionBiplane Simpson's ruleWall motion assessmentVentricular dysfunctionSystolic functionEchocardiographic studyVentricular functionMultivariable analysisPrognostic valueAdverse outcomesPrognostic informationLVEFRegional dysfunction
2005
Left Ventricular Assessment in Myocardial Infarction: The VALIANT Registry
Hernandez AF, Velazquez EJ, Solomon SD, Kilaru R, Diaz R, O’Connor C, Ertl G, Maggioni AP, Rouleau JL, van Gilst W, Pfeffer MA, Califf RM. Left Ventricular Assessment in Myocardial Infarction: The VALIANT Registry. JAMA Internal Medicine 2005, 165: 2162-2169. PMID: 16217008, DOI: 10.1001/archinte.165.18.2162.Peer-Reviewed Original ResearchConceptsHeart failureMyocardial infarctionLV assessmentCardiac catheterizationVentricular assessmentAcute Myocardial Infarction RegistryAngiotensin-converting enzyme inhibitorClinical heart failureMyocardial Infarction RegistryLeft ventricular functionAcute myocardial infarctionQuality of careHospital mortalityHospital outcomesHospital stayBaseline characteristicsDischarge medicationsVentricular functionMultivariable modelPatientsPropensity analysisEnzyme inhibitorsLower mortalityCatheterizationEchocardiography
2003
Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease?
Bourque JM, Velazquez EJ, Borges-Neto S, Shaw LK, Whellan DJ, O’Connor C. Radionuclide viability testing: should it affect treatment strategy in patients with cardiomyopathy and significant coronary artery disease? American Heart Journal 2003, 145: 758-767. PMID: 12766731, DOI: 10.1016/s0002-8703(02)94818-0.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseFemaleFluorodeoxyglucose F18Heart FailureHumansMaleMyocardial RevascularizationProspective StudiesRadiopharmaceuticalsRetrospective StudiesSurvival RateThallium RadioisotopesTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, LeftConceptsSignificant coronary artery diseaseCoronary artery diseaseLong-term mortalityArtery diseaseSurvival rateHeart failureTreatment strategiesImpaired left ventricular functionLong-term mortality ratesIschemic heart failureLeft ventricular functionIntermediate survival ratesNuclear imaging studiesLack of randomizationLower survival rateEjection fractionVentricular functionViable myocardiumReferral biasStudy protocolTreatment allocationLarge cohortPrognostic studiesMortality ratePatients