2018
The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients
Friedman DJ, Fudim M, Overton R, Shaw LK, Patel D, Pokorney SD, Velazquez EJ, Al-Khatib SM. The relationship between baseline and follow-up left ventricular ejection fraction with adverse events among primary prevention ICD patients. American Heart Journal 2018, 201: 17-24. PMID: 29910051, PMCID: PMC6309220, DOI: 10.1016/j.ahj.2018.03.017.Peer-Reviewed Original ResearchConceptsLeft ventricular assist devicePrimary prevention ICD patientsAppropriate ICD therapyVentricular ejection fractionImplantable cardioverter defibrillatorICD therapyICD implantationEjection fractionICD patientsMultivariable Cox proportional hazards modelsPrimary prevention implantable cardioverter defibrillatorsCo-primary study endpointsPrimary prevention ICD recipientsFollow-up left ventricular ejection fractionLeft ventricular ejection fractionCox proportional hazards modelComposite of timeLong-term followProportional hazards modelVentricular assist deviceLong-term riskBaseline LVEFLVEF improvementAdverse eventsComposite endpoint
2017
Impact of Intubation Time on Survival following Coronary Artery Bypass Grafting: Insights from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial
Bouabdallaoui N, Stevens SR, Doenst T, Wrobel K, Bouchard D, Deja MA, Michler RE, Chua YL, Kalil RAK, Selzman CH, Daly RC, Sun B, Djokovic LT, Sopko G, Velazquez EJ, Rouleau JL, Lee KL, Al-Khalidi HR, Investigators F. Impact of Intubation Time on Survival following Coronary Artery Bypass Grafting: Insights from the Surgical Treatment for Ischemic Heart Failure (STICH) Trial. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 1256-1263. PMID: 29422280, PMCID: PMC6517319, DOI: 10.1053/j.jvca.2017.12.038.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIntubation timeArtery bypassSurgical treatmentRisk factorsNew York Heart Association classMultivariable Cox proportional hazards modelsIschemic Heart Failure (STICH) trialPrevious coronary artery bypassMultivariable logistic regression modelCox proportional hazards modelPostoperative intubation timeHeart Failure TrialSystolic volume indexIschemic heart failureMitral valve proceduresIdentification of patientsMortality risk factorsStrong independent predictorProportional hazards modelStrongest predictorLogistic regression modelsPostoperative mortalitySTICH trialPerioperative factorsLeft ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization
Buggey J, Alenezi F, Yoon HJ, Phelan M, DeVore AD, Khouri MG, Schulte PJ, Velazquez EJ. Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization. ESC Heart Failure 2017, 4: 432-439. PMID: 29154416, PMCID: PMC5695196, DOI: 10.1002/ehf2.12159.Peer-Reviewed Original ResearchConceptsAcute heart failure hospitalizationVentricular global longitudinal strainAbnormal LV-GLSLV-GLSHeart failure hospitalizationGlobal longitudinal strainAcute HFpEFFailure hospitalizationEjection fractionHeart failureLongitudinal strainCox proportional hazards modelDuke University Medical CenterComposite of mortalityMedian LV-GLSWorse LV-GLSChronic heart failureWorse clinical outcomesMyocardial systolic dysfunctionSpeckle-tracking analysisProportional hazards modelUniversity Medical CenterMultivariable adjustmentSystolic dysfunctionBaseline characteristics
2016
Pulmonary function and adverse cardiovascular outcomes: Can cardiac function explain the link?
Peña M, Dunning A, Schulte PJ, Durheim MT, Kussin P, Checkley W, Velazquez EJ. Pulmonary function and adverse cardiovascular outcomes: Can cardiac function explain the link? Respiratory Medicine 2016, 121: 4-12. PMID: 27888991, DOI: 10.1016/j.rmed.2016.10.009.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionAdverse cardiovascular eventsPulmonary functionCause mortalityCardiovascular eventsCardiac hospitalizationCardiac functionDecreased LVEFNormal left ventricular ejection fractionSingle tertiary care medical centerTertiary care medical centerCox proportional hazards modelLeft heart remodelingRight heart dysfunctionAdverse cardiovascular outcomesRight ventricular functionTertiary care centerVentricular ejection fractionVentricular internal dimensionLeft heart structuresLeft heart sizeProportional hazards modelMultivariable linear regressionDecreased FVCCardiovascular outcomes
2015
The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison
Velazquez EJ, Samad Z, Al-Khalidi HR, Sangli C, Grayburn PA, Massaro JM, Stevens SR, Feldman TE, Krucoff MW. The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison. American Heart Journal 2015, 170: 1050-1059.e3. PMID: 26542516, DOI: 10.1016/j.ahj.2015.08.004.Peer-Reviewed Original ResearchConceptsMitraClip patientsCox proportional hazards modelPropensity-matched comparisonSevere MR patientsHigh surgical riskHigh-risk patientsNon-surgical treatmentKaplan-Meier estimatesMitral regurgitation patientsProportional hazards modelSurvival benefitMedical therapySurgical riskMitral regurgitationRelative riskBaseline differencesHigh riskMR patientsHazards modelMitraClipPatientsFurther adjustmentLaboratory databasePropensity scorePatient matchingManagement and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction
Samad Z, Shaw LK, Phelan M, Ersboll M, Risum N, Al-Khalidi HR, Glower DD, Milano CA, Alexander JH, O'Connor CM, Wang A, Velazquez EJ. Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction. European Heart Journal 2015, 36: 2733-2741. PMID: 26233850, DOI: 10.1093/eurheartj/ehv343.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSevere mitral regurgitationEvent-free survival benefitHigher event-free survivalSevere functional mitral regurgitationMV surgerySevere LV dysfunctionEvent-free survivalOutcomes of patientsMitral regurgitationFunctional mitral regurgitationIPW adjustmentSystolic dysfunctionLV dysfunctionSurvival benefitEntire cohortTreatment strategiesSevere left ventricular systolic dysfunctionCoronary artery bypass graft surgeryMultivariable Cox proportional hazards modelsSevere left ventricular dysfunctionArtery bypass graft surgeryLeft ventricular systolic dysfunctionCox proportional hazards modelIsolated MV surgery
2014
Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records
Bloomfield GS, Hogan JW, Keter A, Holland TL, Sang E, Kimaiyo S, Velazquez EJ. Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records. BMC Infectious Diseases 2014, 14: 284. PMID: 24886474, PMCID: PMC4046023, DOI: 10.1186/1471-2334-14-284.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLower blood pressureHigher systolic blood pressureCardiovascular risk factorsBlood pressure levelsBlood pressureHigh blood pressureHigher mortality riskMortality rateHazard ratioRisk factorsIncidence rateRetrospective analysisMortality riskLarge HIV treatment programHuman immunodeficiency virus (HIV) infectionNormal systolic blood pressureProportional hazards regression modelsCox proportional hazards modelAdvanced HIV diseaseNon-communicable causeHIV-seropositive individualsHIV-seropositive adultsImmunodeficiency virus infectionHIV treatment programs
2013
Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction
Wang N, Shah A, Querejeta G, Gupta D, Velazquez E, Califf R, Mcmurray J, Pfeffer M, Solomon S. Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction. European Heart Journal 2013, 34: p662. DOI: 10.1093/eurheartj/eht307.p662.Peer-Reviewed Original ResearchWall motion scoreLV ejection fractionHeart failureLV dysfunctionRegional cardiac functionLongitudinal strainEjection fractionClinical outcomesCardiac functionMultivariate Cox proportional hazards modelCox proportional hazards modelPost-myocardial infarction patientsLV wall motion scoreAbnormal wall motion scoreRegional cardiac dysfunctionLeft ventricular dysfunctionLeft ventricular functionMyocardial infarction patientsSpeckle tracking echocardiographySegmental longitudinal strainRegional longitudinal strainProportional hazards modelRegional myocardial functionPeak longitudinal strainNormal reference values
2010
The inter‐relationship of diabetes and left ventricular systolic function on outcome after high‐risk myocardial infarction
Shah AM, Uno H, Køber L, Velazquez EJ, Maggioni AP, MacDonald MR, Petrie MC, McMurray JJ, Califf RM, Pfeffer MA, Solomon SD. The inter‐relationship of diabetes and left ventricular systolic function on outcome after high‐risk myocardial infarction. European Journal Of Heart Failure 2010, 12: 1229-1237. PMID: 20965879, DOI: 10.1093/eurjhf/hfq179.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionRecurrent myocardial infarctionHF hospitalizationRisk of deathMyocardial infarctionCause mortalityHigh riskSpectrum of LVEFHigh-risk post-MI patientsBaseline left ventricular ejection fractionHigher left ventricular ejection fractionHigh-risk myocardial infarctionAcute Myocardial Infarction trialCox proportional hazards modelPost-MI populationHeart failure hospitalizationMyocardial Infarction trialNon-diabetic patientsVentricular systolic functionVentricular ejection fractionPost-MI patientsAcute myocardial infarctionPotent risk factorProportional hazards modelFailure hospitalization
2009
Usefulness of the Duke Sudden Cardiac Death Risk Score for Predicting Sudden Cardiac Death in Patients With Angiographic (>75% Narrowing) Coronary Artery Disease
Atwater BD, Thompson VP, Vest RN, Shaw LK, Mazzei WR, Al-Khatib SM, Hranitzky PM, Bahnson TD, Velazquez EJ, Califf RM, Lee KL, Roe MT. Usefulness of the Duke Sudden Cardiac Death Risk Score for Predicting Sudden Cardiac Death in Patients With Angiographic (>75% Narrowing) Coronary Artery Disease. The American Journal Of Cardiology 2009, 104: 1624-1630. PMID: 19962465, DOI: 10.1016/j.amjcard.2009.07.042.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseSCD risk scoreRisk of SCDArtery diseaseRisk scoreSCD riskDepressed left ventricular ejection fractionAngiographic coronary artery diseasePredicting Sudden Cardiac DeathLeft ventricular ejection fractionNative coronary artery stenosisCox proportional hazards modelVentricular ejection fractionSudden cardiac deathCoronary artery stenosisDeath risk scorePatient characteristic variablesRisk prediction toolsDiseased coronary arteriesProportional hazards modelAngiographic characteristicsRisk patientsCardiac deathCoronary angiographyDiabetes mellitus
2002
Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank)
O’Connor C, Velazquez EJ, Gardner LH, Smith PK, Newman MF, Landolfo KP, Lee KL, Califf RM, Jones RH. Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank). The American Journal Of Cardiology 2002, 90: 101-107. PMID: 12106836, DOI: 10.1016/s0002-9149(02)02429-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationComorbidityCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseDisease-Free SurvivalFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedOutcome and Process Assessment, Health CareSurvival AnalysisTimeTreatment OutcomeVentricular Dysfunction, LeftConceptsCoronary artery bypass surgeryLong-term outcomesMedical therapyCoronary diseaseIschemic cardiomyopathyNew York Heart Association class IILeft ventricular ejection fractionCox proportional hazards modelDuke University Medical CenterDays of catheterizationInitial cardiac catheterizationMedical therapy armObservational treatment comparisonsCoronary artery bypassHeart failure symptomsMedical therapy groupVentricular systolic dysfunctionArtery bypass surgeryVentricular ejection fractionCoronary artery diseaseEpicardial coronary vesselsProportional hazards modelUniversity Medical CenterCABG groupTherapy arm