2019
High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction
Hunter WG, McGarrah RW, Kelly JP, Khouri MG, Craig DM, Haynes C, Felker GM, Hernandez AF, Velazquez EJ, Kraus WE, Shah SH. High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction. Journal Of The American College Of Cardiology 2019, 73: 177-186. PMID: 30654890, DOI: 10.1016/j.jacc.2018.10.059.Peer-Reviewed Original ResearchConceptsLipoprotein particle subfractionsHeart failureEjection fractionTotal HDLSmall HDLMajor adverse cardiac eventsVentricular end-diastolic pressureHDL-P sizeAdverse cardiac eventsReduced ejection fractionEnd-diastolic pressureCox proportional hazardsStrict inclusion criteriaCATHGEN biorepositoryDiastolic dysfunctionAdverse eventsCardiac eventsSequential patientsCardiac catheterizationEndothelial functionMultivariable analysisPrognostic utilityAdverse outcomesClinical covariatesHFpEF
2016
Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure
Hunter WG, Kelly JP, McGarrah RW, Khouri MG, Craig D, Haynes C, Ilkayeva O, Stevens RD, Bain JR, Muehlbauer MJ, Newgard CB, Felker GM, Hernandez AF, Velazquez EJ, Kraus WE, Shah SH. Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure. Journal Of The American Heart Association 2016, 5: e003190. PMID: 27473038, PMCID: PMC5015273, DOI: 10.1161/jaha.115.003190.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionReduced ejection fractionEjection fractionHF controlsHFpEF casesHeart failureMetabolic impairmentVersus Reduced Ejection FractionHistory of HFNormal diastolic functionNovel circulating biomarkersClinical heart failureVentricular ejection fractionDiastolic dysfunction gradeHeart failure pathogenesisStrict inclusion criteriaFatty acid oxidationLVEF spectrumCardiac catheterizationDiastolic functionHF diagnosisSequential patientsMetabolic abnormalitiesInsulin resistanceCirculating BiomarkersImplementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory
Samad Z, Minter S, Armour A, Tinnemore A, Sivak JA, Sedberry B, Strub K, Horan SM, Harrison JK, Kisslo J, Douglas PS, Velazquez EJ. Implementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory. Circulation Cardiovascular Imaging 2016, 9: e003708. PMID: 26957220, DOI: 10.1161/circimaging.115.003708.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisCardiac CatheterizationCritical PathwaysEchocardiography, DopplerFeasibility StudiesHemodynamicsHospitals, High-VolumeHumansObserver VariationPatient Care TeamPractice Patterns, Physicians'Predictive Value of TestsProgram EvaluationProspective StudiesQuality ImprovementQuality Indicators, Health CareReproducibility of ResultsSeverity of Illness IndexWorkflowConceptsAortic stenosisCatheterization dataContinuous quality improvementMean gradientAortic valve mean gradientCQI teamClinical echocardiography laboratoryGreater aortic stenosisProportion of patientsReferral of patientsPrimary outcome measureContinuous quality improvement programQuality Improvement ProgramAortic gradientCardiac catheterizationEchocardiographic diagnosisEchocardiography studyPractice patternsInvasive studiesOutcome measuresEchocardiography laboratoryValve hemodynamicsSecond sonographerCatheterizationCQI program
2015
Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease
Douglas PS, Hoffmann U, Patel MR, Mark DB, Al-Khalidi HR, Cavanaugh B, Cole J, Dolor RJ, Fordyce CB, Huang M, Khan MA, Kosinski AS, Krucoff MW, Malhotra V, Picard MH, Udelson JE, Velazquez EJ, Yow E, Cooper LS, Lee KL. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease. New England Journal Of Medicine 2015, 372: 1291-1300. PMID: 25773919, PMCID: PMC4473773, DOI: 10.1056/nejmoa1415516.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary artery diseaseCTA groupSymptomatic patientsArtery diseaseComposite primary end pointPrimary end-point eventEnd pointRadiation exposureInvasive cardiac catheterizationMajor procedural complicationsPrimary end pointSecondary end pointsEnd-point eventsCumulative radiation exposureMedian followChest painUnstable anginaCardiac catheterizationMore patientsProcedural complicationsClinical outcomesRandomized trialsAnatomical testingMean age
2012
Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: Results from the Duke Databank for Cardiovascular Disease (DDCD)
Williams ES, Thomas KL, Broderick S, Shaw LK, Velazquez EJ, Al-Khatib SM, Daubert JP. Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: Results from the Duke Databank for Cardiovascular Disease (DDCD). American Heart Journal 2012, 164: 434-441. PMID: 22980312, DOI: 10.1016/j.ahj.2012.05.024.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCause mortalityArtery diseaseProlonged QTcRisk factorsQT intervalMortality riskLow glomerular filtration rateHigher diastolic blood pressureNative coronary artery stenosisCardiac risk factorsLow ejection fractionDiastolic blood pressureGlomerular filtration rateCoronary artery stenosisRisk of deathCardiac catheterizationCardiac eventsDuke DatabankBlood pressureEjection fractionQTc intervalQTc prolongationArtery stenosisBaseline electrocardiogramLong-Term Survival of Patients With Ischemic Cardiomyopathy Treated by Coronary Artery Bypass Grafting Versus Medical Therapy
Velazquez EJ, Williams JB, Yow E, Shaw LK, Lee KL, Phillips HR, O'Connor CM, Smith PK, Jones RH. Long-Term Survival of Patients With Ischemic Cardiomyopathy Treated by Coronary Artery Bypass Grafting Versus Medical Therapy. The Annals Of Thoracic Surgery 2012, 93: 523-530. PMID: 22269720, PMCID: PMC3638256, DOI: 10.1016/j.athoracsur.2011.10.064.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCardiovascular AgentsComorbidityCoronary Artery BypassDatabases, FactualFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMitral Valve InsufficiencyModels, CardiovascularMyocardial IschemiaNorth CarolinaRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeConceptsVentricular ejection fractionCoronary artery diseaseMedical therapyArtery diseaseEjection fractionCanadian Cardiovascular Society class III anginaLeft ventricular ejection fractionRisk-adjusted mortality ratesClass III anginaLeft main diseaseCoronary artery bypassLeft main stenosisLong-term mortalityIschemic heart diseaseTrial entry criteriaAcute myocardial infarctionMain outcome measuresPropensity score analysisArtery bypassCohort studyMain stenosisObservational cohortSurvival benefitCardiac catheterizationDuke Databank
2007
Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings
Bourque JM, Velazquez EJ, Tuttle RH, Shaw LK, O’Connor C, Borges-Neto S. Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings. Journal Of Nuclear Cardiology 2007, 14: 165-173. PMID: 17386378, DOI: 10.1016/j.nuclcard.2006.11.011.Peer-Reviewed Original ResearchConceptsMortality riskEjection fractionPrognostic informationHigher long-term mortality ratesLong-term mortality ratesPerfusion single-photon emissionVentricular ejection fractionIschemic heart diseaseLong-term outcomesProportional hazard modelingLong-term survivalSingle photon emissionCardiac catheterizationNormal LVEFRisk stratificationPerfusion findingsPatient prognosticationHeart diseaseRest scoreLVEFMyocardial perfusionMortality ratePerfusion studiesHazard modelingSignificant predictors
2006
Predicting significant coronary artery disease in patients with left ventricular dysfunction
Whellan DJ, Tuttle RH, Velazquez EJ, Shaw LK, Jollis JG, Ellis W, O'Connor CM, Califf RM, Borges-Neto S. Predicting significant coronary artery disease in patients with left ventricular dysfunction. American Heart Journal 2006, 152: 340-347. PMID: 16875920, DOI: 10.1016/j.ahj.2005.12.001.Peer-Reviewed Original ResearchConceptsSignificant coronary artery diseaseCoronary artery diseaseSegmental wall motion abnormalitiesLeft ventricular dysfunctionWall motion abnormalitiesEjection functionCardiac catheterizationVentricular dysfunctionArtery diseaseMedian ageMotion abnormalitiesLikelihood of CADAccurate baseline assessmentPatients' median ageMajor epicardial vesselsDiagnostic cardiac catheterizationNumber of patientsUnnecessary invasive proceduresStepwise logistic regressionClinical characteristicsEchocardiographic parametersPrevalent comorbiditiesDuke DatabankHeart failureDiabetes mellitus
2005
Left Ventricular Assessment in Myocardial Infarction: The VALIANT Registry
Hernandez AF, Velazquez EJ, Solomon SD, Kilaru R, Diaz R, O’Connor C, Ertl G, Maggioni AP, Rouleau JL, van Gilst W, Pfeffer MA, Califf RM. Left Ventricular Assessment in Myocardial Infarction: The VALIANT Registry. JAMA Internal Medicine 2005, 165: 2162-2169. PMID: 16217008, DOI: 10.1001/archinte.165.18.2162.Peer-Reviewed Original ResearchConceptsHeart failureMyocardial infarctionLV assessmentCardiac catheterizationVentricular assessmentAcute Myocardial Infarction RegistryAngiotensin-converting enzyme inhibitorClinical heart failureMyocardial Infarction RegistryLeft ventricular functionAcute myocardial infarctionQuality of careHospital mortalityHospital outcomesHospital stayBaseline characteristicsDischarge medicationsVentricular functionMultivariable modelPatientsPropensity analysisEnzyme inhibitorsLower mortalityCatheterizationEchocardiography