Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth
Chen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA. Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death & Disease 2019, 10: 469. PMID: 31197129, PMCID: PMC6565618, DOI: 10.1038/s41419-019-1679-x.Peer-Reviewed Original ResearchConceptsDJ-1C subunitATP synthaseParkinson's disease protein DJ-1Β-subunitProtein componentsATP synthase β subunitMitochondrial uncouplingDJ-1 bindsATP synthase efficiencyATP synthase F1Synthase β subunitATP production efficiencyProtein DJ-1Neuronal process extensionProtein levelsNeuronal process outgrowthDJ-1 knockoutWild-type counterpartsSubunit protein levelsDJ-1 mutationsSevere defectsCell metabolismKO neuronsKO culturesThe mitochondrial metabolic function of DJ‐1 is modulated by 14‐3‐3β
Weinert M, Millet A, Jonas EA, Alavian KN. The mitochondrial metabolic function of DJ‐1 is modulated by 14‐3‐3β. The FASEB Journal 2019, 33: 8925-8934. PMID: 31034784, PMCID: PMC6988861, DOI: 10.1096/fj.201802754r.Peer-Reviewed Original ResearchConceptsMitochondrial metabolic efficiencyMitochondrial metabolic functionDisease genesMetabolic efficiencyMetabolic functionsMajor signaling pathwaysNovel molecular mechanismHypoxia-dependent mannerParkinson's disease genesKey adaptive mechanismsMitochondrial plasticityChaperone activityCellular metabolic demandsMetabolic plasticityReactive oxygen speciesMolecular mechanismsOxidative phosphorylationPleiotropic functionsSignaling pathwaysDJ-1Cell survivalCancer cellsOxygen speciesAdaptive mechanismsPathophysiological conditions