2017
Impact of Chronic Total Occlusions on Revascularization Scores and Outcome Prediction.
Redfors B, Palmerini T, Caixeta A, Ayele GM, Francese DP, Mehran R, Brilakis ES, Kirtane AJ, Karmpaliotis D, Stone GW, Généreux P. Impact of Chronic Total Occlusions on Revascularization Scores and Outcome Prediction. Journal Of Invasive Cardiology 2017, 29: 123-131. PMID: 28296639.Peer-Reviewed Original ResearchConceptsSYNTAX scoreChronic total occlusionNon-CTO lesionsCTO lesionsTotal occlusionUrgent Intervention Triage Strategy (ACUITY) trialComplex coronary artery diseaseMajor adverse cardiac eventsMedian SYNTAX scoreOverall SYNTAX scoreAdverse cardiac eventsCoronary artery diseaseAcute CatheterizationAngiographic substudyRevascularization scoresCardiac eventsRevascularization strategyArtery diseaseStrategy trialPatientsTraditional SSLesionsOutcome predictionRisk predictionSubstantial proportion
2016
Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions Involving Large Side Branches Outcomes From the Tryton Confirmatory Study
Généreux P, Kumsars I, Schneider JE, Lesiak M, Redfors B, Cornelis K, Selmon MR, Dens J, Hoye A, Metzger DC, Muyldermans L, Slagboom T, Francese DP, Ayele GM, Laak LL, Bartorelli AL, Cutlip DE, Kaplan AV, Leon MB. Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions Involving Large Side Branches Outcomes From the Tryton Confirmatory Study. JACC Cardiovascular Interventions 2016, 9: 1338-1346. PMID: 27388820, DOI: 10.1016/j.jcin.2016.03.042.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBiomarkersChromium AlloysCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary VesselsCreatine Kinase, MB FormEuropeFemaleHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesProsthesis DesignRisk FactorsStentsTime FactorsTreatment OutcomeUnited StatesConceptsTryton Side Branch StentPeriprocedural myocardial infarctionSide Branch StentPivotal RCTsLarge side branchesPrimary endpointMyocardial infarctionBranch StentConfirmatory studiesBifurcation lesionsSide branchesProvisional side branchDedicated bifurcation stentsStent armOnly patientsAngiographic parametersCoronary artery bifurcationsPatientsRCTsSmall side branchesInfarctionOverall trialBifurcation stentsArtery bifurcationPre-defined performance goalAngiographic predictors of 2‐year stent thrombosis in patients receiving drug‐eluting stents: Insights from the ADAPT‐DES study
Généreux P, Redfors B, Witzenbichler B, Maehara A, Yadav M, Weisz G, Francese DP, Parvataneni R, Brener SJ, Mehran R, Kirtane AJ, Stone GW. Angiographic predictors of 2‐year stent thrombosis in patients receiving drug‐eluting stents: Insights from the ADAPT‐DES study. Catheterization And Cardiovascular Interventions 2016, 89: 26-35. PMID: 26813732, DOI: 10.1002/ccd.26409.Peer-Reviewed Original ResearchMeSH KeywordsAgedCase-Control StudiesCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisDrug Therapy, CombinationDrug-Eluting StentsFemaleGermanyHumansMaleMiddle AgedMultivariate AnalysisPercutaneous Coronary InterventionPlatelet ActivationPlatelet Aggregation InhibitorsPlatelet Function TestsPredictive Value of TestsProportional Hazards ModelsProspective StudiesRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsADAPT-DES studyPercutaneous coronary interventionPresence of thrombusStent thrombosisDrug-eluting stentsAngiographic predictorsCardiology/American Heart Association type C lesionsCases of STIndependent angiographic core laboratoryIndex percutaneous coronary interventionMulticenter ADAPT-DES studyMultivariable Cox regression modelsSuccessful percutaneous coronary interventionDetailed angiographic analysisLong target lesionPre-specified analysisType C lesionsAcademic Research ConsortiumSaphenous vein graftsCox regression modelAngiographic core laboratoryADAPT-DESAngiographic variablesCoronary interventionSevere calcification
2015
Risk stratification of patients undergoing medical therapy after coronary angiography
Bettinger N, Palmerini T, Caixeta A, Dressler O, Litherland C, Francese DP, Giustino G, Mehran R, Leon MB, Stone GW, Généreux P. Risk stratification of patients undergoing medical therapy after coronary angiography. European Heart Journal 2015, 37: 3103-3110. PMID: 26685136, DOI: 10.1093/eurheartj/ehv674.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeCoronary AngiographyCoronary Artery DiseaseHumansRisk AssessmentRisk FactorsConceptsMajor adverse cardiac eventsCoronary artery diseaseSYNTAX scoreMedical therapyNSTE-ACSRisk stratificationSegment elevation acute coronary syndromesElevation acute coronary syndromeAdverse ischemic eventsMean SYNTAX scoreAdverse cardiac eventsAcute coronary syndromeBetter prognostic accuracyReceiver operator characteristic analysisImportant clinical implicationsStrongest predictorOperator characteristic analysisACUITY trialCoronary syndromeInitial angiogramCardiac eventsIschemic eventsPrognostic impactArtery diseaseCoronary angiographyReasonable incomplete revascularisation after percutaneous coronary intervention: the SYNTAX Revascularisation Index.
Généreux P, Campos CM, Yadav M, Palmerini T, Caixeta A, Xu K, Francese DP, Dangas GD, Mehran R, Leon MB, Serruys PW, Stone GW. Reasonable incomplete revascularisation after percutaneous coronary intervention: the SYNTAX Revascularisation Index. EuroIntervention 2015, 11: 634-42. PMID: 25308300, DOI: 10.4244/eijy14m10_05.Peer-Reviewed Original ResearchMeSH KeywordsAgedArea Under CurveChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseDecision Support TechniquesFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPercutaneous Coronary InterventionPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsROC CurveTime FactorsTreatment OutcomeConceptsResidual SYNTAX scorePercutaneous coronary interventionBaseline SYNTAX scoreOne-year mortalityCoronary artery diseaseCAD burdenIncomplete revascularisationSYNTAX scoreCoronary interventionOne-year adverse outcomesResidual coronary artery diseaseNew prognostic instrumentPrediction of deathAngiograms of patientsBetter prognostic accuracyDegree of revascularisationACUITY trialArtery diseaseIndependent predictorsMultivariable analysisAdverse outcomesWorse outcomesPrognostic accuracyPrognostic instrumentPatientsOutcomes of a dedicated stent in coronary bifurcations with large side branches: A subanalysis of the randomized TRYTON bifurcation study
Généreux P, Kini A, Lesiak M, Kumsars I, Fontos G, Slagboom T, Ungi I, Metzger DC, Wykrzykowska JJ, Stella PR, Bartorelli AL, Fearon WF, Lefèvre T, Feldman RL, Tarantini G, Bettinger N, Minalu Ayele G, LaSalle L, Francese DP, Onuma Y, Grundeken MJ, Garcia-Garcia HM, Laak LL, Cutlip DE, Kaplan AV, Serruys PW, Leon MB. Outcomes of a dedicated stent in coronary bifurcations with large side branches: A subanalysis of the randomized TRYTON bifurcation study. Catheterization And Cardiovascular Interventions 2015, 87: 1231-1241. PMID: 26397982, DOI: 10.1002/ccd.26240.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCoronary AngiographyCoronary Artery DiseaseCoronary StenosisCoronary ThrombosisFemaleHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesProsthesis DesignRisk FactorsSeverity of Illness IndexSingle-Blind MethodStentsTime FactorsTreatment OutcomeConceptsPrimary end pointPercent diameter stenosisLarge side branchesBifurcation lesionsEnd pointDiameter stenosisMyocardial infarctionSegment percent diameter stenosisPeri-procedural myocardial infarctionAngiographic percent diameter stenosisSide branchesProvisional groupTarget vessel failureTarget vessel revascularizationTrue bifurcation lesionsComplex bifurcation lesionsNon-inferiority marginProvisional stenting strategyPrimary endpointVessel revascularizationTrial cohortCardiac deathTreatment strategiesProvisional stentingSB diameterThe association between the extent of coronary artery disease and major bleeding events after percutaneous coronary intervention: from the ACUITY trial.
Madhavan MV, Généreux P, Palmerini T, Caixeta A, Xu K, McAndrew TC, Francese DP, Kirtane AJ, Mehran R, Stone GW. The association between the extent of coronary artery disease and major bleeding events after percutaneous coronary intervention: from the ACUITY trial. Journal Of Invasive Cardiology 2015, 27: 203-11. PMID: 25840404.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedCoronary AngiographyCoronary Artery BypassCoronary Artery DiseaseFemaleHumansMaleMiddle AgedMulticenter Studies as TopicMultivariate AnalysisPercutaneous Coronary InterventionPostoperative HemorrhageProportional Hazards ModelsProspective StudiesRandomized Controlled Trials as TopicRisk FactorsConceptsNon-ST segment elevation acute coronary syndromesPercutaneous coronary interventionCoronary artery diseaseExtent of CADMajor bleeding ratesSYNTAX scoreACUITY trialMajor bleedingCoronary interventionArtery diseaseBleeding rateSegment elevation acute coronary syndromesSeverity of CADElevation acute coronary syndromeSevere coronary artery diseaseAdverse ischemic eventsMajor bleeding eventsAcute coronary syndromeCommon risk factorsRecurrent adverse eventsBleeding eventsPCI cohortSS tertilesCoronary syndromeHemorrhagic eventsA Randomized Trial of a Dedicated Bifurcation Stent Versus Provisional Stenting in the Treatment of Coronary Bifurcation Lesions
Généreux P, Kumsars I, Lesiak M, Kini A, Fontos G, Slagboom T, Ungi I, Metzger DC, Wykrzykowska JJ, Stella PR, Bartorelli AL, Fearon WF, Lefèvre T, Feldman RL, LaSalle L, Francese DP, Onuma Y, Grundeken MJ, Garcia-Garcia HM, Laak LL, Cutlip DE, Kaplan AV, Serruys PW, Leon MB. A Randomized Trial of a Dedicated Bifurcation Stent Versus Provisional Stenting in the Treatment of Coronary Bifurcation Lesions. Journal Of The American College Of Cardiology 2015, 65: 533-543. PMID: 25677311, DOI: 10.1016/j.jacc.2014.11.031.Peer-Reviewed Original ResearchConceptsTarget vessel failureTrue bifurcation lesionsCoronary bifurcation lesionsBifurcation lesionsProvisional stentingStent groupDiameter stenosisPre-specified noninferiority marginSegment percent diameter stenosisTrue coronary bifurcation lesionsProvisional groupSecondary angiographic endpointsSegment diameter stenosisSymptomatic coronary diseaseBinary restenosis rateMyocardial infarction rateSide branchesPercutaneous coronary interventionPercent diameter stenosisBifurcation coronary lesionsDedicated bifurcation stentsAngiographic cohortInfarction ratePrimary endpointCoronary intervention