2024
A Lymph Node Immune Score (LNIS) Identifies Prognostic Immune Phenotypes Shared across Head and Neck Cancers
Karpinets T, Garden A, Rosenthal D, Fuller C, Frank S, Gunn G, Phan J, Morrison W, Lee A, Moreno A, Song X, Mitani Y, Ferrarotto R, Gross N, Zhang J, Myers J, El-Naggar A, Spiotto M. A Lymph Node Immune Score (LNIS) Identifies Prognostic Immune Phenotypes Shared across Head and Neck Cancers. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s222-s223. DOI: 10.1016/j.ijrobp.2024.07.2308.Peer-Reviewed Original ResearchHead and neck squamous cell cancerNon-small cell lung cancerLymph node metastasisPrognostic gene signatureRelapse free survivalExtranodal extensionFree survivalGene signatureImmune microenvironmentImmune scoreLymph nodesImmune phenotypeRejection subtypeHPV-positive HNSCCImmune rejectionAbsence of extranodal extensionNon-small cell lung cancer cohortsHPV-negative HNSCC patientsUnivariate Cox proportional hazards modelHead and neck cancerImmunology-related genesMetastatic lymph nodesLymph node microenvironmentSquamous cell cancerCell lung cancer
2023
Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation
Mohamed A, Martin G, Ng S, Takiar V, Beadle B, Zafereo M, Garden A, Frank S, Fuller C, Gunn G, Morrison W, Rosenthal D, Reddy J, Moreno A, Lee A, Phan J. Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation. Clinical And Translational Radiation Oncology 2023, 44: 100700. PMID: 38058404, PMCID: PMC10695834, DOI: 10.1016/j.ctro.2023.100700.Peer-Reviewed Original ResearchLocoregional recurrenceSalvage surgeryRecurrent headNeck squamous cell cancerNeck squamous cell carcinomaPhysician's classificationMarginal failureSubsequent locoregional recurrenceSquamous cell cancerSquamous cell carcinomaPatterns of failureLogistic regression analysisDeformable image registrationAdjuvant reirradiationRadiological progressionSurgical salvageInitial recurrenceRecurrent diseaseSalvage rateRecurrent HNSCCCell cancerMucosal sitesCell carcinoma