2024
Clinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation
Bodien Y, Fecchio M, Freeman H, Sanders W, Meydan A, Lawrence P, Kirsch J, Fischer D, Cohen J, Rubin E, He J, Schaefer P, Hochberg L, Rapalino O, Cash S, Young M, Edlow B. Clinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation. Neurology Clinical Practice 2024, 15: e200390. PMID: 39473967, PMCID: PMC11515113, DOI: 10.1212/cpj.0000000000200390.Peer-Reviewed Original ResearchCognitive motor dissociationTask-based functional MRIMotor dissociationLanguage functionEvidence-based guidelinesBehavioral evidenceFunctional MRIEEG assessmentClinical careBrain injuryEvidence baseClinical assessmentPatient selectionClinical implementationPatientsReports lessonsEEGFMRIUnited StatesEffective strategyAssessmentEthical implicationsCareBrainQuantitative and Radiological Assessment of Post-cardiac-Arrest Comatose Patients with Diffusion-Weighted Magnetic Resonance Imaging
Van Roy S, Hsu L, Ho J, Scirica B, Fischer D, Snider S, Lee J. Quantitative and Radiological Assessment of Post-cardiac-Arrest Comatose Patients with Diffusion-Weighted Magnetic Resonance Imaging. Neurocritical Care 2024, 1-10. PMID: 39164537, DOI: 10.1007/s12028-024-02087-y.Peer-Reviewed Original ResearchAnalysis of apparent diffusion coefficientRadiological assessmentMagnetic resonance imagingQuantitative analysis of apparent diffusion coefficientCardiac arrestSubgroup analysisComatose patientsMultimodal approach to prognosticationQuantitative ADC analysisResonance imagingMagnetic resonance imaging reportsDiffusion-weighted magnetic resonance imagingCerebral Performance CategoryDiffusion-weighted imagingAnoxic brain injuryApparent diffusion coefficientDeep gray matter structuresADC analysisRadiological evaluationRetrospective studyADC mapsClinical outcomesAnoxic injuryDiffusion abnormalitiesImaging ReportingAltered Mental Status at the Extreme: Behavioral Evaluation of Disorders of Consciousness
Dhadwal N, Cunningham K, Pino W, Hampton S, Fischer D. Altered Mental Status at the Extreme: Behavioral Evaluation of Disorders of Consciousness. Seminars In Neurology 2024, 44: 621-633. PMID: 39102862, DOI: 10.1055/s-0044-1788807.Peer-Reviewed Original ResearchAcute care settingCare settingsMinimally conscious statePatient's current levelMental statusDisorders of consciousnessComa Recovery Scale-RevisedHealthcare providersGlasgow Coma ScaleAssessment of consciousnessVegetative state/unresponsive wakefulness syndromeAltered mental statusAssessment measuresScale-RevisedState/unresponsive wakefulness syndromeNeurological examComa ScaleConscious stateWakefulness syndromeStatusAssessmentHealthcareSetsMultiple limitationsProvidersComa Prognostication After Acute Brain Injury
Fischer D, Edlow B. Coma Prognostication After Acute Brain Injury. JAMA Neurology 2024, 81: 405-415. PMID: 38436946, DOI: 10.1001/jamaneurol.2023.5634.Peer-Reviewed Original ResearchMagnetic resonance imagingPrognostic markerAcute brain injuryLife-sustaining treatmentBrain injury etiologyPatient's current levelPrediction of neurological recoveryHealth care costsBrain injuryPatient valuesInjury etiologyCare costsPrognostic utilityComa prognosticationSerological markersClinical guidelinesComputed tomographyNeurological recoveryNeurological examinationDisorders of consciousnessNeurological assessmentNeurological functionPredictive valueResonance imagingNeuroprognosticationDisclosing Results of Tests for Covert Consciousness: A Framework for Ethical Translation
Young M, Kazazian K, Fischer D, Lissak I, Bodien Y, Edlow B. Disclosing Results of Tests for Covert Consciousness: A Framework for Ethical Translation. Neurocritical Care 2024, 40: 865-878. PMID: 38243150, PMCID: PMC11147696, DOI: 10.1007/s12028-023-01899-8.Peer-Reviewed Original Research
2023
Come hell or high water: climate change through the lens of neurocritical care
Fischer D. Come hell or high water: climate change through the lens of neurocritical care. Intensive Care Medicine 2023, 49: 1526-1528. PMID: 37982823, DOI: 10.1007/s00134-023-07253-y.Peer-Reviewed Original ResearchNeuroimaging in Disorders of Consciousness and Recovery
Xu L, Hampton S, Fischer D. Neuroimaging in Disorders of Consciousness and Recovery. Physical Medicine And Rehabilitation Clinics Of North America 2023, 35: 51-64. PMID: 37993193, DOI: 10.1016/j.pmr.2023.06.017.Peer-Reviewed Original Research
2022
The biomechanical signature of loss of consciousness: computational modelling of elite athlete head injuries
Zimmerman K, Cournoyer J, Lai H, Snider S, Fischer D, Kemp S, Karton C, Hoshizaki T, Ghajari M, Sharp D. The biomechanical signature of loss of consciousness: computational modelling of elite athlete head injuries. Brain 2022, 146: 3063-3078. PMID: 36546554, PMCID: PMC10316777, DOI: 10.1093/brain/awac485.Peer-Reviewed Original ResearchConceptsAssociated with higher forcesBiomechanical effectsHead impactsLoss of consciousnessTeam medical personnelDystonic posturingDiagnosis of concussionAthletic head injuriesHead injuryStrain rateHigher forcesFootball gamesHigh-fidelity finite element modelHead accelerationAmerican football gamesEvidence of neurological signsMedical personnelAbnormal postureHigh strain ratesPostureFinite element modelVideo signsImpact kinematicsFootball impactsMaintenance of consciousness
2016
Human Sleep- and Wake-Promoting Networks Are Anticorrelated (S13.005)
Boes A, Geerling J, Fischer D, Saper C, Fox M. Human Sleep- and Wake-Promoting Networks Are Anticorrelated (S13.005). Neurology 2016, 86 DOI: 10.1212/wnl.86.16_supplement.s13.005.Peer-Reviewed Original ResearchA Human Brain Network Linking Arousal to Awareness (S35.004)
Fischer D, Boes A, Demertzi A, Evrard H, Laureys S, Edlow B, Saper C, Pascual-Leone A, Fox M, Geerling J. A Human Brain Network Linking Arousal to Awareness (S35.004). Neurology 2016, 86 DOI: 10.1212/wnl.86.16_supplement.s35.004.Peer-Reviewed Original Research
2015
Using Neural Networks to Predict the Effects and Guide the Application of Transcranial Direct Current Stimulation (I6-3B)
Fischer D, Fried P, Pascual-Leone A, Fox M. Using Neural Networks to Predict the Effects and Guide the Application of Transcranial Direct Current Stimulation (I6-3B). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.i6-3b.Peer-Reviewed Original ResearchUsing Neural Networks to Predict the Effects and Guide the Application of Transcranial Direct Current Stimulation (S52.002)
Fischer D, Fried P, Pascual-Leone A, Fox M. Using Neural Networks to Predict the Effects and Guide the Application of Transcranial Direct Current Stimulation (S52.002). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.s52.002.Peer-Reviewed Original ResearchPredicting the Network Effects of Focal Brain Lesions (S52.001)
Boes A, Fischer D, Ayache S, Geerling J, Prasad S, Liu H, Liu Q, Edlow B, Caviness V, Lefaucheur J, Pascual-Leone A, Fox M. Predicting the Network Effects of Focal Brain Lesions (S52.001). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.s52.001.Peer-Reviewed Original ResearchThe Neuroanatomic Basis of Coma in Humans: A Study of Brainstem Lesions and their Cortical Networks (S52.003)
Fischer D, Boes A, Geerling J, Edlow B, Pascual-Leone A, Fox M. The Neuroanatomic Basis of Coma in Humans: A Study of Brainstem Lesions and their Cortical Networks (S52.003). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.s52.003.Peer-Reviewed Original Research
2013
Conscientious of the Conscious: Interactive Capacity as a Threshold Marker for Consciousness
Fischer D, Truog R. Conscientious of the Conscious: Interactive Capacity as a Threshold Marker for Consciousness. AJOB Neuroscience 2013, 4: 26-33. DOI: 10.1080/21507740.2013.819391.Peer-Reviewed Original ResearchMinimally conscious stateDiagnosing disorders of consciousnessBrain-injured patientsAbsence of consciousnessDisorders of consciousnessStates of consciousnessDiagnostic distinctionDiagnosed disordersManagement of patientsConscious stateThreshold markersEthical importanceEthical managementVegetative stateEthical challengesElectroencephalographic assessmentNeuroimagingConsciousness