2019
Adipose glucocorticoid action influences whole‐body metabolism via modulation of hepatic insulin action
Abulizi A, Camporez JP, Jurczak MJ, Høyer KF, Zhang D, Cline GW, Samuel VT, Shulman GI, Vatner DF. Adipose glucocorticoid action influences whole‐body metabolism via modulation of hepatic insulin action. The FASEB Journal 2019, 33: 8174-8185. PMID: 30922125, PMCID: PMC6593882, DOI: 10.1096/fj.201802706r.Peer-Reviewed Original ResearchConceptsWhole-body metabolismHepatic insulin actionHepatic insulin resistanceGlucocorticoid actionHepatic steatosisHepatic glycogen synthesisInsulin resistanceAdipose lipolysisFood intakeInsulin actionAdipose triglyceride lipase expressionGlucose-dependent organsReceptor knockout miceOral glucose challengeHepatic lipid accumulationHigh-fat dietHyperinsulinemic-euglycemic conditionsGlycogen synthesisProtein kinase B phosphorylationInsulin responseGlucose challengeHepatic insulin responseHepatic insulinMetabolic cagesSteatosis
2017
Regulation of hepatic glucose metabolism in health and disease
Petersen MC, Vatner DF, Shulman GI. Regulation of hepatic glucose metabolism in health and disease. Nature Reviews Endocrinology 2017, 13: 572-587. PMID: 28731034, PMCID: PMC5777172, DOI: 10.1038/nrendo.2017.80.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHepatic glucose metabolismGlucose metabolismAdipose lipolysisHepatic insulin resistanceNonesterified fatty acidsGlucose metabolism regulationHepatic glycogen metabolismInsulin resistancePharmacological interventionsPathophysiological processesHepatic gluconeogenesisMajor direct effectAcute regulationGlycogen metabolismInsulinMetabolismLipolysisMetabolism regulationFatty acidsProtein phosphorylationTranscriptional mechanismsAnabolic fluxesDirect effectSubstrate availabilityHyperglucagonaemia