2019
Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1
Chande S, Ho B, Fetene J, Bergwitz C. Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1. PLOS ONE 2019, 14: e0223052. PMID: 31613887, PMCID: PMC6793878, DOI: 10.1371/journal.pone.0223052.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBeta-GlobinsBiological TransportBone DensityCalcitriolChickensCytomegalovirusFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsFounder EffectHemagglutinin Glycoproteins, Influenza VirusHumansMaleMiceMice, TransgenicOsteoblastsParathyroid HormonePhosphatesPrimary Cell CulturePromoter Regions, GeneticRabbitsRecombinant Fusion ProteinsSkullTranscription Factor Pit-1TransgenesConceptsPrimary calvaria osteoblastsLoxP-stop-loxPLoxP-STOP-loxP cassetteMouse modelDihydroxy vitamin D levelsHemagglutinin (HABone mineral densityVitamin D levelsInfluenza hemagglutinin (HAConditional mouse modelActivation of transgene expressionElevated plasma PiTransgenic mouse modelPlasma iPTHUrine PiBeta-globin geneSerum calciumWT littermatesMineral densityDays of ageProtein excretionD levelsSemi-quantitative RT-PCRStandard chowTransgenic mice
2010
Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23
Bergwitz C, Jüppner H. Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23. Annual Review Of Medicine 2010, 61: 91-104. PMID: 20059333, PMCID: PMC4777331, DOI: 10.1146/annurev.med.051308.111339.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParathyroid hormoneDentin matrix protein 1Regulation of phosphate homeostasisVitamin DPhosphate homeostasisFibroblast growth factor 23Serum phosphorus levelsGrowth factor 23Renal phosphate excretionSecretion of FGF23Secretion of parathyroid hormoneSodium-phosphate cotransporters NaPi-IIaCotransporter NaPi-IIaIncreases renal phosphate excretionGenetically engineered miceRegulation of calcium homeostasisHomologies to endopeptidasesKidney axisMatrix protein 1Sodium-phosphate cotransporter NaPi-IIaFactor 23Serum phosphorusPhosphate excretionParathyroid glandsHormonal bone-parathyroid-kidney axis