2020
Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Serna J, Bergwitz C. Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging. Nutrients 2020, 12: 3001. PMID: 33007883, PMCID: PMC7599912, DOI: 10.3390/nu12103001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDietary phosphorusReduced bioavailabilityHealthy agingHigh dietary phosphorusSources of dietary phosphorusReduced longevityAbundance of phosphorusBone metabolismWestern dietPhosphorusTissue calcificationMetabolic changesEndocrine regulationBioavailabilityNormal amountsTissueCurrent knowledgeAbundanceDifferent tissuesExcessive lossOsteomalacia
2019
Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules
Rose E, Lee D, Xiao E, Zhao W, Wee M, Cohen J, Bergwitz C. Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules. Scientific Reports 2019, 9: 8798. PMID: 31217461, PMCID: PMC6584732, DOI: 10.1038/s41598-019-45269-x.Peer-Reviewed Original ResearchConceptsDrosophila renal tubulesFly life spanGenetic ablationRNAi-mediated knockdownInorganic phosphate (Pi) homeostasisHigh-Pi mediumPi transportersAdult fliesControl of FGF signalingHigher speciesPi mediumInduces expressionMFS2FGF signalingExcretion of PiPhosphate homeostasisDrosophilaFly longevityEndocrine regulationHormone fibroblast growth factor 23Renal tubulesHormonal controlPi transportFibroblast growth factor 23Genetic overexpression