2017
Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial
Schneider T, Johns C, Palumbo M, Murphy K, Cahill K, Laidlaw T. Dietary Fatty Acid Modification for the Treatment of Aspirin-Exacerbated Respiratory Disease: A Prospective Pilot Trial. The Journal Of Allergy And Clinical Immunology In Practice 2017, 6: 825-831. PMID: 29133219, PMCID: PMC5945343, DOI: 10.1016/j.jaip.2017.10.011.Peer-Reviewed Original ResearchConceptsAspirin-exacerbated respiratory diseaseUrinary leukotriene EDietary interventionLeukotriene ERespiratory diseaseTreatment of AERDDietary fatty acid modificationAsthma Control Questionnaire scoreNasal Outcome Test (SNOT-22) scoresAdjunct treatment optionProspective pilot trialPatient-reported questionnaireFatty acid consumptionTreatment of aspirinOutcome Test scoresAdult patientsAdverse eventsLung functionPrimary outcomeClinical efficacyVital capacityTreatment optionsWomen's HospitalIntervention periodPilot trial
2016
Automated identification of an aspirin-exacerbated respiratory disease cohort
Cahill K, Johns C, Cui J, Wickner P, Bates D, Laidlaw T, Beeler P. Automated identification of an aspirin-exacerbated respiratory disease cohort. Journal Of Allergy And Clinical Immunology 2016, 139: 819-825.e6. PMID: 27567328, PMCID: PMC5266739, DOI: 10.1016/j.jaci.2016.05.048.Peer-Reviewed Original ResearchConceptsAspirin-exacerbated respiratory diseaseAllergist/immunologistElectronic health recordsPositive predictive valueEHRs of patientsPredictive valueHigh positive predictive valueAnti-inflammatory drugsAERD diagnosisChart reviewNasal polyposisClinical featuresCohort ANasal polypsPartners HealthCare SystemPatient RegistryPatient notesUndiagnosed casesDisease cohortRespiratory diseaseRespiratory reactionsInformatics algorithmClinical expertsSearch termsHealth records
2015
Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease
Lee-Sarwar K, Johns C, Laidlaw T, Cahill K. Tolerance of daily low-dose aspirin does not preclude aspirin-exacerbated respiratory disease. The Journal Of Allergy And Clinical Immunology In Practice 2015, 3: 449-451. PMID: 25634222, PMCID: PMC4426242, DOI: 10.1016/j.jaip.2015.01.007.Peer-Reviewed Original Research
2014
Bacterial metabolites of diet-derived lignans and isoflavones inversely associate with asthma and wheezing
Cardet J, Johns C, Savage J. Bacterial metabolites of diet-derived lignans and isoflavones inversely associate with asthma and wheezing. Journal Of Allergy And Clinical Immunology 2014, 135: 267-269.e14. PMID: 25190319, PMCID: PMC4289106, DOI: 10.1016/j.jaci.2014.07.035.Peer-Reviewed Original ResearchElevated Total Serum IgE in Nonatopic Patients with Aspirin-exacerbated Respiratory Disease
Johns C, Laidlaw T. Elevated Total Serum IgE in Nonatopic Patients with Aspirin-exacerbated Respiratory Disease. American Journal Of Rhinology And Allergy 2014, 28: 287-289. PMID: 25197914, DOI: 10.2500/ajra.2014.28.4054.Peer-Reviewed Original ResearchConceptsAspirin-exacerbated respiratory diseaseElevated total serum IgETotal serum IgESubset of patientsSerum IgERespiratory diseaseNonsteroidal anti-inflammatory drugsOral aspirin challengeHistory of atopyAbsence of atopyRecurrent nasal polypsSubgroup of patientsAllergic-like reactionsAnti-inflammatory drugsPositive test resultsAspirin challengeNonatopic patientsCommon aeroallergensSamter's triadEntire cohortNasal polypsMean bloodAtopyPatientsClinical relevance
2013
Urinary triclosan levels and recent asthma exacerbations
Savage J, Johns C, Hauser R, Litonjua A. Urinary triclosan levels and recent asthma exacerbations. Annals Of Allergy Asthma & Immunology 2013, 112: 179-181.e2. PMID: 24468262, DOI: 10.1016/j.anai.2013.11.017.Peer-Reviewed Original Research