2016
A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury
Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. American Journal Of Respiratory And Critical Care Medicine 2016, 195: 482-490. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedApolipoprotein L1ApolipoproteinsBiomarkersCardiac Surgical ProceduresCase-Control StudiesCritical IllnessFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIntensive Care UnitsInterferon Regulatory Factor-2Lipoproteins, HDLMaleMiddle AgedPolymorphism, Single NucleotidePostoperative ComplicationsRisk FactorsStatistics, NonparametricT-Box Domain ProteinsConceptsAcute kidney injuryGenome-wide association studiesSingle nucleotide polymorphismsKidney injuryGenetic lociAssociation studiesExploratory genome-wide association studyAcute kidney injury casesHospital acute kidney injuryCommon genetic variantsIndependent lociGene TBX1Chromosome 4Novel pathwayCritical illnessCardiac surgerySevere complicationsLociPatient populationTherapeutic advancesGenetic variantsGenotype imputationInjury casesExpedite recoveryInjury
2015
Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery
Zhang WR, Garg AX, Coca SG, Devereaux PJ, Eikelboom J, Kavsak P, McArthur E, Thiessen-Philbrook H, Shortt C, Shlipak M, Whitlock R, Parikh CR. Plasma IL-6 and IL-10 Concentrations Predict AKI and Long-Term Mortality in Adults after Cardiac Surgery. Journal Of The American Society Of Nephrology 2015, 26: 3123-3132. PMID: 25855775, PMCID: PMC4657830, DOI: 10.1681/asn.2014080764.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCanadaCardiac Surgical ProceduresCreatinineFemaleFollow-Up StudiesHumansInterleukin-10Interleukin-6Lipocalin-2LipocalinsMaleMiddle AgedPostoperative PeriodPreoperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsUnited StatesConceptsIL-10 concentrationsIL-6 concentrationsPlasma IL-6IL-6IL-10Cardiac surgeryHigh riskLower riskPeak IL-6 concentrationNeutrophil gelatinase-associated lipocalinPathophysiology of AKIPostoperative IL-6Long-term mortalityGelatinase-associated lipocalinBiomarkers of inflammationRisk of mortalityDose-dependent mannerHospital AKIAKI biomarkersCause mortalityPerioperative outcomesPreoperative concentrationsSerum creatinineDL increaseSecond tertile
2014
Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury
Belcher JM, Sanyal AJ, Peixoto AJ, Perazella MA, Lim J, Thiessen‐Philbrook H, Ansari N, Coca SG, Garcia‐Tsao G, Parikh CR, Consortium F. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology 2014, 60: 622-632. PMID: 24375576, PMCID: PMC4065642, DOI: 10.1002/hep.26980.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAdultAgedAlbuminuriaBiomarkersCreatinineDiagnosis, DifferentialFatty Acid-Binding ProteinsFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansInterleukin-18KidneyLipocalin-2LipocalinsLiver CirrhosisMaleMembrane GlycoproteinsMiddle AgedProspective StudiesProto-Oncogene ProteinsReceptors, VirusSodiumConceptsAcute kidney injuryAcute tubular necrosisKidney injury molecule-1Neutrophil gelatinase-associated lipocalinHepatorenal syndromePrerenal azotemiaKidney injuryDifferential diagnosisUrinary biomarkersEtiology of AKIProgressive acute kidney injuryLiver-type fatty acidOptimal diagnostic cutoffInjury molecule-1Prospective cohort studyGelatinase-associated lipocalinAccurate differential diagnosisClinical decision makingNumber of biomarkersCohort studyTubular necrosisFractional excretionCommon etiologyInterleukin-18Kidney biomarkers
2013
Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery
Coca SG, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Krumholz HM, Shlipak MG, Parikh CR. Urinary Biomarkers of AKI and Mortality 3 Years after Cardiac Surgery. Journal Of The American Society Of Nephrology 2013, 25: 1063-1071. PMID: 24357673, PMCID: PMC4005309, DOI: 10.1681/asn.2013070742.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Long-term mortalityIL-18Urinary biomarkersClinical AKICardiac surgeryHighest tertileUrinary neutrophil gelatinase-associated lipocalinProspective long-term followNeutrophil gelatinase-associated lipocalinContinuous net reclassification improvementInjury molecule-1Kidney injury biomarkersPostoperative day 1Gelatinase-associated lipocalinImmediate postoperative periodAdditional prognostic informationLong-term followNet reclassification improvementMortality 3 yearsLiver fatty acidAKI cohortCause mortalityHospital outcomesKidney injury
2011
Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery
Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX. Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Adult Cardiac Surgery. Journal Of The American Society Of Nephrology 2011, 22: 1748-1757. PMID: 21836143, PMCID: PMC3171945, DOI: 10.1681/asn.2010121302.Peer-Reviewed Original ResearchConceptsPlasma neutrophil gelatinase-associated lipocalinNeutrophil gelatinase-associated lipocalinUrine IL-18Acute kidney injuryUrine neutrophil gelatinase-associated lipocalinPlasma NGAL levelsIL-18Net reclassification improvementCardiac surgeryKidney injuryNGAL levelsPoor outcomeIntensive care unit staySubsequent acute kidney injuryEarly postoperative measuresMulticenter cohort studyGelatinase-associated lipocalinAdult cardiac surgeryReceiver-operating characteristic curveAdverse patient outcomesClinical prediction modelPostoperative biomarkersUnit stayHospital stayMultivariable adjustment