2024
Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies
Amatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.Peer-Reviewed Original ResearchAssociated with incident chronic kidney diseaseIncident chronic kidney diseaseChronic kidney diseaseUrine MCP-1Meta-analysisUrine biomarkersMCP-1A1M concentrationsMultivariable Cox proportional hazards regressionRisk of chronic kidney diseaseRisk of incident chronic kidney diseaseCox proportional hazards regressionIndependent of eGFRPrevalent chronic kidney diseaseCohort of adultsMeta-analysis of resultsA1MLong follow-up periodEarly chronic kidney diseaseFollow-up periodProportional hazards regressionUrine A1MARIC participantsREGARDS studyHealth markersPHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.
Parikh C, Hernandez J. PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS. Transactions Of The American Clinical And Climatological Association 2024, 134: 37-46. PMID: 39135588, PMCID: PMC11316880.Peer-Reviewed Original ResearchConceptsAcute kidney injuryChronic kidney diseaseKidney injuryEpisodes of acute kidney injuryAssociated with long-term riskLong-term risk of readmissionLong-term sequelaeRepair biomarkersRisk of readmissionSubclinical inflammationPreclinical studiesUrine biomarkersResearch biopsiesDeceased donor kidneysClinical trialsKidney diseaseBlood pressureMedical managementDonor kidneysPragmatic clinical trialsKidney tissueTherapeutic developmentOrgan allocationPrecision medicineKidney
2023
Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus
Vasquez-Rios G, Katz R, Levitan E, Cushman M, Parikh C, Kimmel P, Bonventre J, Waikar S, Schrauben S, Greenberg J, Sarnak M, Ix J, Shlipak M, Gutierrez O. Urinary Biomarkers of Kidney Tubule Health and Mortality in Persons with CKD and Diabetes Mellitus. Kidney360 2023, 4: e1257-e1264. PMID: 37533144, PMCID: PMC10547219, DOI: 10.34067/kid.0000000000000226.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Monocyte chemoattractant protein-1Kidney tubule healthCause-specific mortalityUrine biomarkersYKL-40Risk factorsCardiovascular deathCause mortalityHigh riskChitinase-3-like protein 1Greater riskHigher MCP-1Higher urine levelsUrine KIM-1Injury molecule-1Cause-specific deathMortality risk factorsProportional hazards regressionRisk of deathAdditional risk factorsProtein 1Cancer-related deathChemoattractant protein-1Alpha-1-microglobulin