Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidenceAn FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin
Bello D, Smith TJ, Woskie SR, Streicher RP, Boeniger MF, Redlich CA, Liu Y. An FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin. Environmental Science Processes & Impacts 2006, 8: 523-529. PMID: 16688353, DOI: 10.1039/b517948c.Peer-Reviewed Original ResearchConceptsMethylenediphenyl diisocyanateIsocyanate groupsTotal reflectance Fourier transformReflectance Fourier transformHexamethylene diisocyanate isocyanurateTotal isocyanate groupFTIR investigationAromatic isocyanatesGuinea pig skinChemical groupsIsocyanatesUnreacted speciesSmall compoundsUnreacted compoundsDermal exposureEthyl acetateIsocyanurateHairless guinea pig skinPig skinCompoundsSkin surfaceContact dermatitisDecontamination strategiesResidence timeSkin absorption