2019
Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia
Haghighat L, Ionescu CN, Regan CJ, Altin SE, Attaran RR, Mena-Hurtado CI. Review of the Current Basic Science Strategies to Treat Critical Limb Ischemia. Vascular And Endovascular Surgery 2019, 53: 316-324. PMID: 30808262, DOI: 10.1177/1538574419831489.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaDevelopment of CLIMolecular therapyPoor surgical candidatesImpairment of angiogenesisSurgical candidatesMicrovascular changesNovel imaging modalityTreatment optionsMorbid diseaseTranslational medicine studiesTherapyMedicine studiesImaging modalitiesIschemiaDiseasePatientsPathophysiologyArteriogenesisImpairmentTrials
2018
Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds
Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/circimaging.117.006932.Peer-Reviewed Original ResearchMeSH KeywordsAnkle Brachial IndexCase-Control StudiesCritical IllnessDiabetic FootHumansIschemiaMicrocirculationOrganophosphorus CompoundsOrganotechnetium CompoundsPerfusion ImagingPredictive Value of TestsRadiopharmaceuticalsRegional Blood FlowSingle Photon Emission Computed Tomography Computed TomographyWound HealingConceptsCritical limb ischemiaAnkle-brachial indexStandardized uptake valueSPECT/CT imagingDiabetic patientsHealthy subjectsSPECT/CTFoot perfusionUptake valueLimb ischemiaMicrovascular perfusionSkeletal muscle microvascular perfusionCT imagingDiabetic CLI patientsMuscle microvascular perfusionPeripheral artery diseaseSingle photon emissionIntraclass correlation coefficientAngiosome perfusionCLI subjectsCLI patientsArtery diseaseDiabetes mellitusCT perfusionVascular territories