The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients
Margaroli C, Cardenas M, Jansen C, Reyes A, Hosseinzadeh F, Hong G, Zhang Y, Kissick H, Tirouvanziam R, Master V. The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients. OncoImmunology 2020, 9: 1747731. PMID: 32313729, PMCID: PMC7153842, DOI: 10.1080/2162402x.2020.1747731.Peer-Reviewed Original ResearchConceptsKidney cancer patientsTumor microenvironmentArginase-1Tumor tissuesActivated phenotypeCancer patientsMyeloid-derived suppressor cellsImmature-like phenotypeTumor-infiltrating neutrophilsTumor-associated neutrophilsEnzyme arginase-1Associated with obesityPhenotype of neutrophilsAdipose tissue distributionMetabolic statePatient's metabolic stateSuppressor cellsImmunosuppressive phenotypeImmunosuppressive roleTumor progressionTumor neutrophilsDisease progressionCirculating neutrophilsTumorGranule release