2021
A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes
Calagua C, Ficial M, Jansen C, Hirz T, Del Balzo L, Wilkinson S, Lake R, Ku A, Voznesensky O, Sykes D, Saylor P, Ye H, Signoretti S, Kissick H, Sowalsky A, Balk S, Einstein D. A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes. Clinical Cancer Research 2021, 27: 4836-4847. PMID: 34168052, PMCID: PMC8416924, DOI: 10.1158/1078-0432.ccr-21-0121.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaCD8<sup>+</sup> T cellsImmune checkpoint inhibitorsPD-L1 expressionLocalized prostate cancerPrimary prostate cancerProstate cancerT cellsPD-L1Density of CD8<sup>+</sup> T cellsHigh-risk primary prostate cancerCD8 T-cell densityCharacterized tumor infiltrating lymphocytesLocalized prostate cancer casesPD-1<sup>+</sup> cellsTumor PD-L1 expressionUnique tumor immune microenvironmentPD-1 expressionTumor-infiltrating lymphocytesT-cell densityCD8 T cellsTumor immune microenvironmentTumor mutational burdenProstate cancer casesT-cell content
2019
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells
Jansen C, Prokhnevska N, Master V, Sanda M, Carlisle J, Bilen M, Cardenas M, Wilkinson S, Lake R, Sowalsky A, Valanparambil R, Hudson W, McGuire D, Melnick K, Khan A, Kim K, Chang Y, Kim A, Filson C, Alemozaffar M, Osunkoya A, Mullane P, Ellis C, Akondy R, Im S, Kamphorst A, Reyes A, Liu Y, Kissick H. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature 2019, 576: 465-470. PMID: 31827286, PMCID: PMC7108171, DOI: 10.1038/s41586-019-1836-5.Peer-Reviewed Original ResearchConceptsCD8 T cellsStem-like CD8 T cellsT cellsStem-like T cellsCD8 T cell infiltrationCD8 T cell responsesMechanism of immune escapeTumor-infiltrating lymphocytesT cell infiltrationT cell responsesStem-like cellsSurvival benefitImmune nicheProgressive diseaseImmune escapeTumor typesTumorCD8Human cancersDifferentiation processLymphocytesPatientsCancerInfiltrationSurvivalAbstract 2700: CD8 T-cell infiltration into renal tumors requires a supportive antigen-presenting niche
Jansen C, Prokhnevska N, Master V, Carlisle J, Bilen M, Reyes A, Kissick H. Abstract 2700: CD8 T-cell infiltration into renal tumors requires a supportive antigen-presenting niche. Cancer Research 2019, 79: 2700-2700. DOI: 10.1158/1538-7445.am2019-2700.Peer-Reviewed Original ResearchCD8 T cell infiltrationT cell infiltrationTumor-infiltrating lymphocytesT cell responsesRenal cell carcinomaStem-like T cellsCancer-specific survivalT cellsRenal tumorsPatient survivalCD8 tumor-infiltrating lymphocytesPoor T-cell infiltrationDisease progressionAnti-tumor immune responseCD8 T cell responsesImmune responseTumor-infiltrating immune cellsFlow cytometryRenal cell carcinoma patientsCD8 T cellsStage III patientsIntensification of therapyRenal cell tumorsFollow-up timeEmory University Hospital
2018
Immunologic profile and prognostic significance of tumor-infiltrating lymphocytes in renal cell carcinoma.
Khan A, Jansen C, Wilkinson Carlisle J, Melnick K, Kim K, Hosseinzadeh F, Prokhnevska N, Bilen M, Master V, Kissick H. Immunologic profile and prognostic significance of tumor-infiltrating lymphocytes in renal cell carcinoma. Journal Of Clinical Oncology 2018, 36: 673-673. DOI: 10.1200/jco.2018.36.6_suppl.673.Peer-Reviewed Original ResearchUCLA Integrated Staging SystemTumor-infiltrating lymphocytesVenous tumor thrombusRenal cell carcinomaPrimary tumorCD8+Cell carcinomaPhenotype of tumor-infiltrating lymphocytesSignificance of tumor-infiltrating lymphocytesCo-inhibitory receptor expressionNon-metastatic primary tumorsHigher treatment failureCD8+ cellsIntegrated Staging SystemAssociated with recurrencePhenotype of primary tumorsMayo stageTIL levelsCD28+Tumor thrombusCo-stimulatoryEvaluate recurrencePrognostic factorsPrognostic scorePrognostic significance