2023
Abstract B030: Form and function in intratumoral immune organization: Understanding the cellular composition of TCF1+ CD8+ T cell niches in human cancer
Jansen C, Vo B, Sobierajska E, Greenwald R, Mullane P, Prokhnevska N, Cardenas M, Bilen M, Osunkoya A, Master V, Kissick H. Abstract B030: Form and function in intratumoral immune organization: Understanding the cellular composition of TCF1+ CD8+ T cell niches in human cancer. Cancer Research 2023, 83: b030-b030. DOI: 10.1158/1538-7445.kidney23-b030.Peer-Reviewed Original ResearchTertiary lymphoid structuresSecondary lymphoid tissuesT cell responsesT cell zonesImmune nicheB cell zonesT cell nicheLymphoid tissueT cellsTumor tissuesEffective anti-tumor T cell responsesAnti-tumor T cell responsesDevelopment of T-cell functionStem-like CD8 T cellsImmune organsCD8 T cell activationCD8 T cell infiltrationTumor-infiltrating T cellsRobust T cell responsesCellular compositionB cell presenceHuman cancersAnti-tumor immunityResponse to immunotherapyCD8 T cells
2022
1033 Stem-like CD8 T-cells residing in antigen presenting immune niches are prognostic for local control in brain metastases and are sustained following radiation therapy
Jansen C, Chappa P, Prokhnevska N, Cardenas M, Prabhu R, Zhong J, Hoang K, Goyal S, Logan S, Olson J, Nduom E, Balzo L, Patel K, Burri S, Asher A, Wilkinson S, Lake R, Higgins K, Patel P, Dhere V, Torres M, Sowalsky A, Khan M, Kissick H, Buchwald Z. 1033 Stem-like CD8 T-cells residing in antigen presenting immune niches are prognostic for local control in brain metastases and are sustained following radiation therapy. 2022, a1075-a1075. DOI: 10.1136/jitc-2022-sitc2022.1033.Peer-Reviewed Original ResearchCD8 T cell activation in cancer is comprised of two distinct phases
Prokhnevska N, Cardenas M, Valanparambil R, Sobierajska E, Jansen C, Master V, Sanda M, Kissick H. CD8 T cell activation in cancer is comprised of two distinct phases. The Journal Of Immunology 2022, 208: 121.09-121.09. DOI: 10.4049/jimmunol.208.supp.121.09.Peer-Reviewed Original ResearchStem-like CD8 T cellsCD8 T cellsTumor-draining LNCD8 T cell activationT cellsT cell activationCo-stimulationLCMV-GPTumor-specific CD8 T cellsT cell responses to tumorsHeterogeneous T-cell subsetsCD8 T cell differentiationAutologous dendritic cellsProstate cancer modelResponse to tumorsT cell subsetsAntigen presenting cellsCo-stimulatory signalsTumor-bearing miceT cell differentiationStem-like phenotypeDifferentiation ex vivoCD8 responsesEffector phenotypeDendritic cells
2021
658 CD8 T cell activation in cancer is comprised of two distinct phases
Prokhnevska N, Cardenas M, Valanparambil R, Sobierajska E, Jansen C, Master V, Sanda M, Kissick H. 658 CD8 T cell activation in cancer is comprised of two distinct phases. Journal For ImmunoTherapy Of Cancer 2021, 9: a686-a686. DOI: 10.1136/jitc-2021-sitc2021.658.Peer-Reviewed Original ResearchTumor-draining lymph nodesCD8 T cell activationCD8 T cellsStem-like CD8 T cellsT cell activationResponse to tumorsT cellsCo-stimulationEffector programTumor-specific CD8 T cellsImmune response to tumorsSubsets of CD8 T cellsModel of T cell differentiationActivated CD8 T cellsProstate cancer mouse modelCD8 T cell biologyCancer mouse modelAntigen presenting cellsT cell differentiationT cell biologyStem-like cellsAutologous tumorCD8 infiltrationCD8 subsetsEffector phenotypeCD8 T cell differentiation in cancer is comprised of two distinct phases
Prokhnevska N, Cardenas M, Valanparambil R, Jansen C, Master V, Sanda M, Kissick H. CD8 T cell differentiation in cancer is comprised of two distinct phases. The Journal Of Immunology 2021, 206: 57.04-57.04. DOI: 10.4049/jimmunol.206.supp.57.04.Peer-Reviewed Original ResearchTumor-specific CD8 T cellsTumor-draining lymph nodesCD8 T cellsCD8 T cell differentiationResponse to tumorsT cellsT cell differentiationStem-like CD8 T cellsT cell responses to tumorsUndifferentiated phenotypeImmune response to tumorsSubsets of CD8 T cellsCD8 T cell subsetsImmune response to cancerTumor-specific antigensProstate cancer modelT cell subsetsHuman prostate cancerDraining lymph nodesResponse to cancerCD8 infiltrationLCMV glycoproteinProstate cancerLymph nodesCD8
2020
Tumor-specific CD8 T cell activation in draining lymph nodes supports the anti-tumor CD8 T cell response
Prokhnevska N, Cardenas M, Jansen C, Valanparambil R, Master V, Sanda M, Kissick H. Tumor-specific CD8 T cell activation in draining lymph nodes supports the anti-tumor CD8 T cell response. The Journal Of Immunology 2020, 204: 165.5-165.5. DOI: 10.4049/jimmunol.204.supp.165.5.Peer-Reviewed Original ResearchTumor-specific CD8 T cellsCD8 T cellsStem-like CD8 T cellsCD8 T cell activationT cellsT cell activationEffector programLymph nodesCD8 T cell responsesImmune response to tumorsTumor-draining lymph nodesCD8 T cell infiltrationSubsets of CD8 T cellsAnti-tumor responsesT cell infiltrationResponse to tumorsTumor-specific antigensProstate cancer modelT cell responsesDraining lymph nodesAcute viral infectionT cell immunologyCD8 responsesLCMV glycoproteinCD62L expression
2019
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells
Jansen C, Prokhnevska N, Master V, Sanda M, Carlisle J, Bilen M, Cardenas M, Wilkinson S, Lake R, Sowalsky A, Valanparambil R, Hudson W, McGuire D, Melnick K, Khan A, Kim K, Chang Y, Kim A, Filson C, Alemozaffar M, Osunkoya A, Mullane P, Ellis C, Akondy R, Im S, Kamphorst A, Reyes A, Liu Y, Kissick H. An intra-tumoral niche maintains and differentiates stem-like CD8 T cells. Nature 2019, 576: 465-470. PMID: 31827286, PMCID: PMC7108171, DOI: 10.1038/s41586-019-1836-5.Peer-Reviewed Original ResearchConceptsCD8 T cellsStem-like CD8 T cellsT cellsStem-like T cellsCD8 T cell infiltrationCD8 T cell responsesMechanism of immune escapeTumor-infiltrating lymphocytesT cell infiltrationT cell responsesStem-like cellsSurvival benefitImmune nicheProgressive diseaseImmune escapeTumor typesTumorCD8Human cancersDifferentiation processLymphocytesPatientsCancerInfiltrationSurvival