Abstract B009: Isolating human RCC tumor cells details evolutionary relationships between cancer cell subsets and a role of OXPHOS in disease progression
Sobierajska E, Medina C, Gregorova P, Vo B, Greenwald R, Jansen C, Larsen C, Master V, Kissick H. Abstract B009: Isolating human RCC tumor cells details evolutionary relationships between cancer cell subsets and a role of OXPHOS in disease progression. Cancer Research 2023, 83: b009-b009. DOI: 10.1158/1538-7445.kidney23-b009.Peer-Reviewed Original ResearchOxidative phosphorylationEvolutionary relationshipsRNA-seqCancer cellsCancer cell subsetsRCC tumor cellsWhole-genome sequencingMutation detection sensitivityDisease progressionUnique to cancer cellsKidney cancer cellsCell differentiation pathsIncreased oxidative phosphorylationCell subsetsEpithelial to mesenchymal transitionGenome sequenceIncreased proliferative stateTumor cellsTumor tissuesScRNA-seqOxidative metabolismAssociated with disease recurrenceCD8 T cell numbersMitochondrial potentialMitochondrial fitness