640 Stem-like CD4 T cells in cancer
Cardenas M, Prokhnevska N, Jansen C, Master V, Kissick H. 640 Stem-like CD4 T cells in cancer. Journal For ImmunoTherapy Of Cancer 2021, 9: a669-a669. DOI: 10.1136/jitc-2021-sitc2021.640.Peer-Reviewed Original ResearchCD4 T cellsAnti-tumor responsesT cellsTh1-likeEffector subsetsEffector lineagesTumor-infiltrating CD4 T cellsVirus-specific CD4 T cellsInfiltrating CD4 T cellsResponses to tumor antigensFlow cytometryEx vivo functional analysisProstate cancer mouse modelCancer mouse modelGenes associated with stemnessEmory University HospitalPlasticity in vitroKidney cancer patientsHypothesis in vivoLCMV glycoproteinCD4 subsetTfh cellsTreg cellsEffector populationsTumor antigens658 CD8 T cell activation in cancer is comprised of two distinct phases
Prokhnevska N, Cardenas M, Valanparambil R, Sobierajska E, Jansen C, Master V, Sanda M, Kissick H. 658 CD8 T cell activation in cancer is comprised of two distinct phases. Journal For ImmunoTherapy Of Cancer 2021, 9: a686-a686. DOI: 10.1136/jitc-2021-sitc2021.658.Peer-Reviewed Original ResearchTumor-draining lymph nodesCD8 T cell activationCD8 T cellsStem-like CD8 T cellsT cell activationResponse to tumorsT cellsCo-stimulationEffector programTumor-specific CD8 T cellsImmune response to tumorsSubsets of CD8 T cellsModel of T cell differentiationActivated CD8 T cellsProstate cancer mouse modelCD8 T cell biologyCancer mouse modelAntigen presenting cellsT cell differentiationT cell biologyStem-like cellsAutologous tumorCD8 infiltrationCD8 subsetsEffector phenotype