2021
640 Stem-like CD4 T cells in cancer
Cardenas M, Prokhnevska N, Jansen C, Master V, Kissick H. 640 Stem-like CD4 T cells in cancer. Journal For ImmunoTherapy Of Cancer 2021, 9: a669-a669. DOI: 10.1136/jitc-2021-sitc2021.640.Peer-Reviewed Original ResearchCD4 T cellsAnti-tumor responsesT cellsTh1-likeEffector subsetsEffector lineagesTumor-infiltrating CD4 T cellsVirus-specific CD4 T cellsInfiltrating CD4 T cellsResponses to tumor antigensFlow cytometryEx vivo functional analysisProstate cancer mouse modelCancer mouse modelGenes associated with stemnessEmory University HospitalPlasticity in vitroKidney cancer patientsHypothesis in vivoLCMV glycoproteinCD4 subsetTfh cellsTreg cellsEffector populationsTumor antigens
2020
CD4 T cell phenotypes differentially modulate the CD8 T cell response in kidney cancer
Cardenas M, Prokhnevska N, Jansen C, Master V, Kissick H. CD4 T cell phenotypes differentially modulate the CD8 T cell response in kidney cancer. The Journal Of Immunology 2020, 204: 165.1-165.1. DOI: 10.4049/jimmunol.204.supp.165.1.Peer-Reviewed Original ResearchTumor-infiltrating CD4 T cellsInfiltrating CD4 T cellsCD8 T cell responsesCD4 T cellsAnti-tumor responsesT cell responsesCD8 T cell infiltrationT cellsKidney cancer patientsTumor-specific CD8 T-cell responsesTumor-infiltrating CD8 T cellsSubsets of CD4 T cellsCancer patientsCD8 T cell functionMaster transcription factor Foxp3CD8 T cell differentiationCD4 T cell phenotypeRenal cell carcinoma patientsResponse to immunotherapyCD8 T cellsT cell infiltrationT regulatory cellsT-cell phenotypeCell carcinoma patientsTranscription factor Foxp3The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients
Margaroli C, Cardenas M, Jansen C, Reyes A, Hosseinzadeh F, Hong G, Zhang Y, Kissick H, Tirouvanziam R, Master V. The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients. OncoImmunology 2020, 9: 1747731. PMID: 32313729, PMCID: PMC7153842, DOI: 10.1080/2162402x.2020.1747731.Peer-Reviewed Original ResearchConceptsKidney cancer patientsTumor microenvironmentArginase-1Tumor tissuesActivated phenotypeCancer patientsMyeloid-derived suppressor cellsImmature-like phenotypeTumor-infiltrating neutrophilsTumor-associated neutrophilsEnzyme arginase-1Associated with obesityPhenotype of neutrophilsAdipose tissue distributionMetabolic statePatient's metabolic stateSuppressor cellsImmunosuppressive phenotypeImmunosuppressive roleTumor progressionTumor neutrophilsDisease progressionCirculating neutrophilsTumorGranule release