2023
Abstract B009: Isolating human RCC tumor cells details evolutionary relationships between cancer cell subsets and a role of OXPHOS in disease progression
Sobierajska E, Medina C, Gregorova P, Vo B, Greenwald R, Jansen C, Larsen C, Master V, Kissick H. Abstract B009: Isolating human RCC tumor cells details evolutionary relationships between cancer cell subsets and a role of OXPHOS in disease progression. Cancer Research 2023, 83: b009-b009. DOI: 10.1158/1538-7445.kidney23-b009.Peer-Reviewed Original ResearchOxidative phosphorylationEvolutionary relationshipsRNA-seqCancer cellsCancer cell subsetsRCC tumor cellsWhole-genome sequencingMutation detection sensitivityDisease progressionUnique to cancer cellsKidney cancer cellsCell differentiation pathsIncreased oxidative phosphorylationCell subsetsEpithelial to mesenchymal transitionGenome sequenceIncreased proliferative stateTumor cellsTumor tissuesScRNA-seqOxidative metabolismAssociated with disease recurrenceCD8 T cell numbersMitochondrial potentialMitochondrial fitness
2020
The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients
Margaroli C, Cardenas M, Jansen C, Reyes A, Hosseinzadeh F, Hong G, Zhang Y, Kissick H, Tirouvanziam R, Master V. The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients. OncoImmunology 2020, 9: 1747731. PMID: 32313729, PMCID: PMC7153842, DOI: 10.1080/2162402x.2020.1747731.Peer-Reviewed Original ResearchConceptsKidney cancer patientsTumor microenvironmentArginase-1Tumor tissuesActivated phenotypeCancer patientsMyeloid-derived suppressor cellsImmature-like phenotypeTumor-infiltrating neutrophilsTumor-associated neutrophilsEnzyme arginase-1Associated with obesityPhenotype of neutrophilsAdipose tissue distributionMetabolic statePatient's metabolic stateSuppressor cellsImmunosuppressive phenotypeImmunosuppressive roleTumor progressionTumor neutrophilsDisease progressionCirculating neutrophilsTumorGranule release
2019
Abstract 2700: CD8 T-cell infiltration into renal tumors requires a supportive antigen-presenting niche
Jansen C, Prokhnevska N, Master V, Carlisle J, Bilen M, Reyes A, Kissick H. Abstract 2700: CD8 T-cell infiltration into renal tumors requires a supportive antigen-presenting niche. Cancer Research 2019, 79: 2700-2700. DOI: 10.1158/1538-7445.am2019-2700.Peer-Reviewed Original ResearchCD8 T cell infiltrationT cell infiltrationTumor-infiltrating lymphocytesT cell responsesRenal cell carcinomaStem-like T cellsCancer-specific survivalT cellsRenal tumorsPatient survivalCD8 tumor-infiltrating lymphocytesPoor T-cell infiltrationDisease progressionAnti-tumor immune responseCD8 T cell responsesImmune responseTumor-infiltrating immune cellsFlow cytometryRenal cell carcinoma patientsCD8 T cellsStage III patientsIntensification of therapyRenal cell tumorsFollow-up timeEmory University Hospital