1996
The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation.
Leitenberg D, Novak TJ, Farber D, Smith BR, Bottomly K. The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation. Journal Of Experimental Medicine 1996, 183: 249-259. PMID: 8551228, PMCID: PMC2192406, DOI: 10.1084/jem.183.1.249.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigen PresentationBase SequenceCD4 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineFlow CytometryImmunologic CappingLeukocyte Common AntigensLymphocyte ActivationMolecular Sequence DataPhenotypePhosphatidylinositol Diacylglycerol-LyasePhosphoric Diester HydrolasesProtein BindingReceptors, Antigen, T-CellRecombinant ProteinsStructure-Activity RelationshipTransfectionConceptsT cell receptorMolecular weight isoformsCD45 isoformsHigh molecular weight isoformsWeight isoformsAntigen-presenting cellsAntigen-specific stimulationT lymphocyte activationPanel of transfectantsLow molecular weight isoformsHigh molecular weight CD45 isoformsT helper 2 clonesCell receptor complexSpecific antigenT cell transfectants
1990
Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells.
Strair R, Towle M, Heald P, Smith B. Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells. Blood 1990, 76: 1201-8. PMID: 2144777, DOI: 10.1182/blood.v76.6.1201.bloodjournal7661201.Peer-Reviewed Original ResearchConceptsAdenovirus E2 promoterBeta-galactosidase geneLymphoid cellsE2 promoterRecombinant retrovirusPrimary lymphoid cellsPrimary cellsSpecific cell typesViral gene productsLymphoproliferative disordersBeta-galactosidase activityGene productsMalignant cellsSimilar infectionsExogenous genesExogenous promoterTransactivator activityCell typesPromoterGenesInfectionRetrovirusesCellsExpressionPatientsRetroviral mediated gene transfer into bone marrow progenitor cells: use of beta-galactosidase as a selectable marker
Strair R, Towle M, Smith B. Retroviral mediated gene transfer into bone marrow progenitor cells: use of beta-galactosidase as a selectable marker. Nucleic Acids Research 1990, 18: 4759-4762. PMID: 2118622, PMCID: PMC331937, DOI: 10.1093/nar/18.16.4759.Peer-Reviewed Original Research