2017
Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R
Mitchell JK, Midkiff BR, Israelow B, Evans MJ, Lanford RE, Walker CM, Lemon SM, McGivern DR. Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R. MBio 2017, 8: e00121-17. PMID: 28442604, PMCID: PMC5405228, DOI: 10.1128/mbio.00121-17.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEIF-2 KinaseHep G2 CellsHepacivirusHepatitis CHost-Pathogen InteractionsHumansPan troglodytesTumor Suppressor Protein p53ConceptsHepatitis C virusHCV infectionC virusProtein kinase RHCV replicationLiver cancerHost responseHepatocellular carcinogenesisP53 functionHCV protein expressionHCV RNA replicationP53 responseLiver-derived HepG2 cellsDNA damageOncogenic RNA virusesInfectious causesChronic infectionRNA replicationPhosphorylated protein kinase RActivation of p53Viral activationInfectionMicroRNA-122P53-mediated responseP53 inhibition
2013
Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies
Sourisseau M, Michta ML, Zony C, Israelow B, Hopcraft SE, Narbus CM, Martín A, Evans MJ. Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies. PLOS Pathogens 2013, 9: e1003244. PMID: 23555257, PMCID: PMC3605286, DOI: 10.1371/journal.ppat.1003244.Peer-Reviewed Original ResearchConceptsHCV cell entryHepatitis C virusClaudin-1Complete HCV life cycleCell entryTight junction protein claudin-1HCV life cyclePost-binding stageMiR-122 expressionHepatitis C virus cell entryHepG2 cellsNumerous host factorsVirus cell entryHCV therapyLiver diseaseC virusInfection assaysBlocking antibodiesHCV isolatesSR-BIHost cell entryHost factorsUtilization differencesMajor causeOccludin