2014
HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection
Israelow B, Narbus CM, Sourisseau M, Evans MJ. HepG2 cells mount an effective antiviral interferon‐lambda based innate immune response to hepatitis C virus infection. Hepatology 2014, 60: 1170-1179. PMID: 24833036, PMCID: PMC4176518, DOI: 10.1002/hep.27227.Peer-Reviewed Original ResearchConceptsInnate immune responseHCV infectionHuh-7.5 cellsInnate immune systemImmune responseImmune systemAntiviral responseEntire HCV life cycleHepatitis C virus exposurePersistent life-long infectionHepatitis C virus infectionMelanoma differentiation-associated protein 5C virus infectionRobust antiviral responseImportance of IFNHuh-7Retinoic acid-inducible gene IHCV life cycleAcid-inducible gene ILife-long infectionInnate immune antagonistsHepG2 cellsLike receptor pathwayLiver-specific microRNAHCV recognition
2013
Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies
Sourisseau M, Michta ML, Zony C, Israelow B, Hopcraft SE, Narbus CM, Martín A, Evans MJ. Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies. PLOS Pathogens 2013, 9: e1003244. PMID: 23555257, PMCID: PMC3605286, DOI: 10.1371/journal.ppat.1003244.Peer-Reviewed Original ResearchConceptsHCV cell entryHepatitis C virusClaudin-1Complete HCV life cycleCell entryTight junction protein claudin-1HCV life cyclePost-binding stageMiR-122 expressionHepatitis C virus cell entryHepG2 cellsNumerous host factorsVirus cell entryHCV therapyLiver diseaseC virusInfection assaysBlocking antibodiesHCV isolatesSR-BIHost cell entryHost factorsUtilization differencesMajor causeOccludin