2022
PDE4DIP in health and diseases
Mani A. PDE4DIP in health and diseases. Cellular Signalling 2022, 94: 110322. PMID: 35346821, PMCID: PMC9618167, DOI: 10.1016/j.cellsig.2022.110322.Peer-Reviewed Original ResearchConceptsSecond messengerClass of enzymesCyclic AMPRecent genetic studiesSpecific cell functionsAnchoring proteinsDynamic microdomainsPathological cardiac remodelingExcitation-contraction couplingIntracellular targetingSpecific proteinsGenetic studiesCell survivalIntracellular messengerStimulating pathwaysCAMP-dependent phosphodiesteraseHeart failureDiverse classAtrial fibrillationCardiac remodelingInjury resultsPredominant isoformFunction of organsConduction velocityHeart rate
2016
Metabolic syndrome
Ziki M, Mani A. Metabolic syndrome. Current Opinion In Lipidology 2016, 27: 162-171. PMID: 26825138, PMCID: PMC5141383, DOI: 10.1097/mol.0000000000000276.Peer-Reviewed Original ResearchConceptsMetabolic traitsGenome-wide association studiesCognate pathwaysDiverse traitsMultifactorial heritabilityDisease genesAssociation studiesGenetic studiesTraitsGenetic investigationsCommon variantsDisease mechanismsGenetic causeGenetic risk factorsHomogenous populationDisease pathophysiologyQuantitative distributionGenesVariantsHeritabilityExtreme endsSubstantial progressKindredsPathwayLarge effect