2022
Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules
Parchure A, Tian M, Stalder D, Boyer C, Bearrows S, Rohli K, Zhang J, Rivera-Molina F, Ramazanov B, Mahata S, Wang Y, Stephens S, Gershlick D, von Blume J. Liquid–liquid phase separation facilitates the biogenesis of secretory storage granules. Journal Of Cell Biology 2022, 221: e202206132. PMID: 36173346, PMCID: PMC9526250, DOI: 10.1083/jcb.202206132.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkLiquid-liquid phase separationSecretory granulesClient moleculesSecretory storage granulesΒ-cellsMembrane traffickingCargo receptorsPlasma membranePancreatic β-cellsProcessing enzymesCell typesStorage granulesChromogranin proteinsBiogenesisAcidic pHTraffickingGranulesProteinEnzyme
2021
Cargo sorting at the trans-Golgi network at a glance
Ford C, Parchure A, von Blume J, Burd CG. Cargo sorting at the trans-Golgi network at a glance. Journal Of Cell Science 2021, 134 PMID: 34870705, PMCID: PMC8714066, DOI: 10.1242/jcs.259110.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkDistinct export pathwaysClathrin-coated vesiclesTrafficking of glycoproteinsMechanism of proteinEndo-lysosomal organellesAccompanying posterGlance articleResident proteinsExport pathwayGolgi functionTrans-GolgiDifferent organellesGolgi cisternaeKey molecular featuresTrans cisternaeMembrane sacsFinal compartmentGolgiCell surfaceDistinct repertoireCell scienceTransport carriersProteinOrganelles
2017
Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens
Parchure A, Vyas N, Mayor S. Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens. Trends In Cell Biology 2017, 28: 157-170. PMID: 29132729, PMCID: PMC6941938, DOI: 10.1016/j.tcb.2017.10.003.Peer-Reviewed Original ResearchGetting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door
Parchure A, Munson M, Budnik V. Getting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door. Neuron 2017, 96: 604-615. PMID: 29096075, DOI: 10.1016/j.neuron.2017.10.020.Peer-Reviewed Original ResearchConceptsNuclear pore complexNE buddingNuclear envelope buddingProtein synthesis machineryLocalization of RNAEndogenous cellular processesNuclear escapeLarge RNPsPore complexSynthesis machineryNuclear assemblyTransport granulesCellular processesNuclear exportSynaptic plasticityProtein aggregatesBuddingViral capsidRecent findingsSynthetic activitySynaptic sitesRecent studiesPlasticityDrosophilaRibonucleoprotein