2012
Systemic Antibody Responses to the Immunodominant p23 Antigen and p23 Polymorphisms in Children with Cryptosporidiosis in Bangladesh
Borad AJ, Allison GM, Wang D, Ahmed S, Karim MM, Kane AV, Moy J, Hibberd PL, Ajjampur SS, Kang G, Calderwood SB, Ryan ET, Naumova E, Khan WA, Ward HD. Systemic Antibody Responses to the Immunodominant p23 Antigen and p23 Polymorphisms in Children with Cryptosporidiosis in Bangladesh. American Journal Of Tropical Medicine And Hygiene 2012, 86: 214-222. PMID: 22302851, PMCID: PMC3269270, DOI: 10.4269/ajtmh.2012.11-0273.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAmino Acid SequenceAntibodies, ProtozoanAntibody FormationAntigens, ProtozoanBangladeshCase-Control StudiesChildCryptosporidiosisCryptosporidiumCryptosporidium parvumDiarrheaFemaleFollow-Up StudiesHumansImmunodominant EpitopesImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleMolecular Sequence DataPolymorphism, Single NucleotideRecombinant ProteinsSequence AlignmentSequence Analysis, DNAConceptsAntibody responseVaccine candidatesCross-reactive antibody responsesPutative vaccine candidatesUninfected childrenIgA responsesSystemic antibodiesAcute diarrheaIgM responsePersistent diarrheaSerum IgAProlonged diseaseSerum IgMImmune responseDiarrheaGene polymorphismsMost childrenProtective antigenMajor causeAntigenSubtype familiesChildrenP23 antigenCryptosporidium hominisCryptosporidiosis
2011
Antibody Responses to the Immunodominant Cryptosporidium gp15 Antigen and gp15 Polymorphisms in a Case–Control Study of Cryptosporidiosis in Children in Bangladesh
Allison GM, Rogers KA, Borad A, Ahmed S, Karim MM, Kane AV, Hibberd PL, Naumova EN, Calderwood SB, Ryan ET, Khan WA, Ward HD. Antibody Responses to the Immunodominant Cryptosporidium gp15 Antigen and gp15 Polymorphisms in a Case–Control Study of Cryptosporidiosis in Children in Bangladesh. American Journal Of Tropical Medicine And Hygiene 2011, 85: 97-104. PMID: 21734132, PMCID: PMC3122351, DOI: 10.4269/ajtmh.2011.11-0043.Peer-Reviewed Original ResearchConceptsSerum IgA responseCase-control studyYears of ageUninfected childrenIgA responsesAcute diarrheaAntibody levelsPersistent diarrheaSerum IgGAntibody responseProlonged diseaseImmune responseVaccine candidatesBangladeshi childrenDiarrheaAntigenC. parvumSignificant correlationC. hominisChildrenFurther investigationDominant Cryptosporidium speciesCryptosporidium speciesHominisPolymorphism
2010
Human immune responses in cryptosporidiosis
Borad A, Ward H. Human immune responses in cryptosporidiosis. Future Microbiology 2010, 5: 507-519. PMID: 20210556, PMCID: PMC2856646, DOI: 10.2217/fmb.09.128.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAnimalsCryptosporidiosisCryptosporidiumHumansImmunity, CellularImmunity, InnateImmunity, MucosalProtozoan VaccinesConceptsHuman immune responseImmune responseToll-like receptor pathwayCell-mediated responsesMucosal antibody responsesAdaptive immune responsesPutative protective antigensInnate immune responseMannose-binding lectinAntibody responseT cellsIFN-gammaCryptosporidium infectionTherapeutic interventionsReceptor pathwayProtective antigenCryptosporidiosisCritical roleResponseAntimicrobial peptidesChemokinesCytokinesFurther knowledgeProstaglandinsInfection