Systemic Antibody Responses to the Immunodominant p23 Antigen and p23 Polymorphisms in Children with Cryptosporidiosis in Bangladesh
Borad AJ, Allison GM, Wang D, Ahmed S, Karim MM, Kane AV, Moy J, Hibberd PL, Ajjampur SS, Kang G, Calderwood SB, Ryan ET, Naumova E, Khan WA, Ward HD. Systemic Antibody Responses to the Immunodominant p23 Antigen and p23 Polymorphisms in Children with Cryptosporidiosis in Bangladesh. American Journal Of Tropical Medicine And Hygiene 2012, 86: 214-222. PMID: 22302851, PMCID: PMC3269270, DOI: 10.4269/ajtmh.2012.11-0273.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAmino Acid SequenceAntibodies, ProtozoanAntibody FormationAntigens, ProtozoanBangladeshCase-Control StudiesChildCryptosporidiosisCryptosporidiumCryptosporidium parvumDiarrheaFemaleFollow-Up StudiesHumansImmunodominant EpitopesImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleMolecular Sequence DataPolymorphism, Single NucleotideRecombinant ProteinsSequence AlignmentSequence Analysis, DNAConceptsAntibody responseVaccine candidatesCross-reactive antibody responsesPutative vaccine candidatesUninfected childrenIgA responsesSystemic antibodiesAcute diarrheaIgM responsePersistent diarrheaSerum IgAProlonged diseaseSerum IgMImmune responseDiarrheaGene polymorphismsMost childrenProtective antigenMajor causeAntigenSubtype familiesChildrenP23 antigenCryptosporidium hominisCryptosporidiosis