2024
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea.
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionNovel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAPArousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study
Zinchuk A, Walker A, Kushida C, Wellman A, Yaggi H, Sands S. Arousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study. Sleep Medicine 2024, 115: 324-325. DOI: 10.1016/j.sleep.2023.11.876.Peer-Reviewed Original Research
2021
Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.
Zinchuk AV, Chu JH, Liang J, Celik Y, Op de Beeck S, Redeker NS, Wellman A, Yaggi HK, Peker Y, Sands SA. Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease. American Journal Of Respiratory And Critical Care Medicine 2021, 204: 703-712. PMID: 34156917, PMCID: PMC8521693, DOI: 10.1164/rccm.202101-0055oc.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseObstructive sleep apneaLong-term CPAP adherenceContinuous positive airway pressureCPAP adherenceCPAP useLow ArTHArtery diseaseUntreated obstructive sleep apneaObjective CPAP adherencePositive airway pressureOSA characteristicsPharyngeal collapsibilityRICCADSA trialAirway pressureSleep apneaClinical comorbiditiesAdverse outcomesPoor adherenceClinical trialsAdherence determinantsLow adherenceCommon treatmentArousal thresholdApnea therapy
2018
Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea.
Zinchuk A, Edwards BA, Jeon S, Koo BB, Concato J, Sands S, Wellman A, Yaggi HK. Prevalence, Associated Clinical Features, and Impact on Continuous Positive Airway Pressure Use of a Low Respiratory Arousal Threshold Among Male United States Veterans With Obstructive Sleep Apnea. Journal Of Clinical Sleep Medicine 2018, 14: 809-817. PMID: 29734986, PMCID: PMC5940432, DOI: 10.5664/jcsm.7112.Peer-Reviewed Original ResearchConceptsLong-term CPAP useObstructive sleep apneaLow respiratory arousal thresholdLow ArTHRespiratory arousal thresholdCPAP useNonobese patientsClinical featuresSleep apneaOdds ratioArousal thresholdContinuous positive airway pressure usePositive airway pressure usePhysiologic phenotypeRegular CPAP useAntihypertensive medication useBody mass indexAssociated clinical featuresUnited States veteransAntihypertensive medicationsPolysomnography characteristicsClinical characteristicsCPAP adherenceAntidepressant useMedication use