2023
Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival
Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes T, Djamali A, Gallon L, O'Connell P, He J, Pober J, Heeger P, Menon M. Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. Journal Of Clinical Investigation 2023, 133: e170420. PMID: 37676733, PMCID: PMC10617779, DOI: 10.1172/jci170420.Peer-Reviewed Original ResearchConceptsDeath-censored graft lossHuman leukocyte antigenExpression quantitative trait lociT cellsTGF-β1TGF-β1/Smad pathwayDonor-recipient differencesKidney allograft lossChronic allograft rejectionKidney transplant survivalDonor-recipient mismatchActive TGF-β1Allograft lossGraft lossAllograft rejectionTransplant cohortPeripheral bloodLeukocyte antigenClinical trialsImmune cellsHaplotype mismatchGenome-wide scaleTransplant survivalQuantitative trait lociSingle nucleotide polymorphism data
2022
Role of time from transplantation to biopsy in histologic ABMR: A single center report
Chancay J, Liu C, Chauhan K, Andersen L, Harris C, Coca S, Delaney V, Tedla F, De Boccardo G, Sehgal V, Moledina D, Formica R, Reghuvaran A, Banu K, Florman S, Akalin E, Shapiro R, Salem F, Menon MC. Role of time from transplantation to biopsy in histologic ABMR: A single center report. Clinical Transplantation 2022, 36: e14802. PMID: 36069577, PMCID: PMC10211409, DOI: 10.1111/ctr.14802.Peer-Reviewed Original ResearchConceptsDeath-censored graft lossAntibody-Mediated RejectionDonor-specific antibodiesMicrovascular inflammationDQ-DSAAnti-human leukocyte antigen donor-specific antibodiesChronic allograft injurySingle-center reportsHigher inflammatory scoresCause biopsiesAllograft injuryGraft lossChronicity scoreInflammatory scoreHistologic factorsCT scoreFemale recipientsBiopsyMVI scoreT-scoreHeterogeneous etiologyCenter ReportTransplantationScoresSignificant correlation