2023
Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study
Xu H, Toikumo S, Crist R, Glogowska K, Jinwala Z, Deak J, Justice A, Gelernter J, Johnson E, Kranzler H, Kember R. Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study. Addiction 2023, 118: 1942-1952. PMID: 37156939, PMCID: PMC10754226, DOI: 10.1111/add.16229.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSignificant single nucleotide polymorphismsSubstance use traitsMulti-trait analysisAssociation studiesGenetic architectureUse traitsGenome-wide significant single nucleotide polymorphismsProtein-protein interaction analysisTrait genetic architectureNumber of lociPolygenic risk scoresEuropean ancestry individualsNovel lociSingle nucleotide polymorphismsGenetic lociGWAS studiesLociMultiple related phenotypesNucleotide polymorphismsRelated phenotypesTraitsNovel associationsMTAgBiobank samples
2020
Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program
Serper M, Vujkovic M, Kaplan DE, Carr RM, Lee KM, Shao Q, Miller DR, Reaven PD, Phillips LS, O’Donnell C, Meigs JB, Wilson PWF, Vickers-Smith R, Kranzler HR, Justice AC, Gaziano JM, Muralidhar S, Pyarajan S, DuVall SL, Assimes TL, Lee JS, Tsao PS, Rader DJ, Damrauer SM, Lynch JA, Saleheen D, Voight BF, Chang KM, . Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program. PLOS ONE 2020, 15: e0237430. PMID: 32841307, PMCID: PMC7447043, DOI: 10.1371/journal.pone.0237430.Peer-Reviewed Original ResearchMeSH Keywords17-Hydroxysteroid DehydrogenasesAbdomenAdaptor Proteins, Signal TransducingAgedAlanine TransaminaseElectronic Health RecordsFemaleGenetic LociGenetic Predisposition to DiseaseGenetic VariationHumansLipaseLiverLysophospholipaseMaleMembrane ProteinsMiddle AgedNon-alcoholic Fatty Liver DiseasePhenotypeRisk FactorsVeteransConceptsMetabolic risk factorsNAFLD phenotypeAlanine aminotransferaseUnits/LElectronic health recordsAdvanced fibrosisRisk factorsMillion Veteran ProgramAlcohol consumptionNon-invasive criteriaNormal alanine aminotransferaseNAFLD fibrosis scorePopulation-based studyGenetic variantsFatty liver phenotypeVeteran ProgramPNPLA3 locusNAFLD riskLiver biopsyLiver diseaseFibrosis scoreEHR reviewUS veteransBiopsy dataAbdominal imaging