2020
Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools
Akgün KM, Sigel K, Cheung KH, Kidwai-Khan F, Bryant AK, Brandt C, Justice A, Crothers K. Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools. PLOS ONE 2020, 15: e0227730. PMID: 31945115, PMCID: PMC6964890, DOI: 10.1371/journal.pone.0227730.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesData MiningElectronic Health RecordsForced Expiratory VolumeHealth Information SystemsHospitalizationHumansLungNatural Language ProcessingPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSoftwareUnited StatesUnited States Department of Veterans AffairsVeteransVital CapacityConceptsChronic obstructive pulmonary diseaseVeterans Aging Cohort StudyObstructive pulmonary diseaseFEV1 valuesPulmonary diseasePhenotyping of patientsPulmonary function testsAging Cohort StudyLung function measurementsElectronic health record dataHealth record dataStructured electronic health record dataPositive predictive valueElectronic health recordsAirflow obstructionChart reviewCohort studyExpiratory volumeCOPD phenotypesFunction testsVital capacityFEV1 measurementsDATA SOURCESPredictive valueClinical notes
2018
Accuracy of electronic health record data for the diagnosis of chronic obstructive pulmonary disease in persons living with HIV and uninfected persons
Crothers K, Rodriguez CV, Nance RM, Akgun K, Shahrir S, Kim J, Hoo G, Sharafkhaneh A, Crane HM, Justice AC. Accuracy of electronic health record data for the diagnosis of chronic obstructive pulmonary disease in persons living with HIV and uninfected persons. Pharmacoepidemiology And Drug Safety 2018, 28: 140-147. PMID: 29923258, PMCID: PMC6309326, DOI: 10.1002/pds.4567.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAge FactorsAlgorithmsBronchodilator AgentsCohort StudiesData AccuracyData Interpretation, StatisticalDrug PrescriptionsElectronic Health RecordsFemaleHIV InfectionsHumansInternational Classification of DiseasesLogistic ModelsMaleMiddle AgedNebulizers and VaporizersPrevalencePulmonary Disease, Chronic ObstructiveRisk FactorsSmokingSpirometryConceptsChronic obstructive pulmonary diseaseICD-9 codesObstructive pulmonary diseaseElectronic health record dataHealth record dataPulmonary diseaseHIV-Associated Lung Emphysema (EXHALE) studyIntegrated Clinical Systems cohortVeterans Aging Cohort StudyHIV uninfected personsAIDS Research NetworkAging Cohort StudyRecord dataEHR dataReceiver-operating curveCohort studyRespiratory symptomsHIV statusUninfected personsClinical variablesDevelopment cohortClinical indicationsSpirometry dataSpirometryUninfected individualsMarkers of chronic obstructive pulmonary disease are associated with mortality in people living with HIV
Triplette M, Justice A, Attia EF, Tate J, Brown ST, Goetz MB, Kim JW, Rodriguez-Barradas MC, Hoo GWS, Wongtrakool C, Akgün K, Crothers K. Markers of chronic obstructive pulmonary disease are associated with mortality in people living with HIV. AIDS 2018, 32: 487-493. PMID: 29135579, PMCID: PMC6366454, DOI: 10.1097/qad.0000000000001701.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersFemaleHIV InfectionsHumansLongitudinal StudiesLungMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRespiratory Function TestsSurvival AnalysisTomography, X-Ray ComputedConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseRisk of deathStudy participantsVACS IndexPulmonary diseaseComputed tomographyImpact of COPDVeterans Aging Cohort Study (VACS) IndexMultivariable Cox regression modelsBurden of comorbiditiesPredictors of mortalityPulmonary function testingCox regression modelMedian followUninfected subjectsAirflow obstructionCohort studyPulmonary functionPulmonary variablesFunction testingMultivariable modelPLWHCT characteristicsMortality rate
2016
Association of chronic obstructive pulmonary disease with frailty measurements in HIV-infected and uninfected Veterans
Akgün KM, Tate JP, Oursler KK, Crystal S, Leaf DA, Womack JA, Brown TT, Justice AC, Crothers K. Association of chronic obstructive pulmonary disease with frailty measurements in HIV-infected and uninfected Veterans. AIDS 2016, 30: 2185-2193. PMID: 27191979, DOI: 10.1097/qad.0000000000001162.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCross-Sectional StudiesFemaleFrailtyHIV InfectionsHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveVeteransConceptsUninfected participantsVACS IndexHIV statusPhysical activityChronic obstructive pulmonary disease (COPD) prevalenceChronic obstructive pulmonary diseasePhysical limitation scaleLow physical activityObstructive pulmonary diseaseCross-sectional studyPhysiologic frailtyUninfected veteransCOPD managementFrailty measurementPulmonary diseaseUnadjusted analysesLimitation ScalePhysiologic biomarkersCOPDFunctional limitationsHIVUninfected individualsClinical biomarkersSelf-report survey itemsDisease prevalence
2010
HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era
Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC, Oursler KK, Rimland D, Gibert CL, Butt AA, Justice AC. HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era. American Journal Of Respiratory And Critical Care Medicine 2010, 183: 388-395. PMID: 20851926, PMCID: PMC3266024, DOI: 10.1164/rccm.201006-0836oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCombination antiretroviral therapy eraAntiretroviral therapy eraPulmonary diseaseTherapy eraPulmonary infectionHIV infectionVeterans Aging Cohort Study Virtual CohortIncident chronic obstructive pulmonary diseaseLower HIV RNA levelsVirtual cohortVeterans Affairs Healthcare SystemAssociation of HIVMost pulmonary diseasesHIV RNA levelsRates of asthmaIncidence rate ratiosSelf-reported smokingLarge Health SurveyPulmonary hypertensionUninfected patientsComorbid diseasesOpportunistic pneumoniaBacterial pneumonia
2006
Increased COPD Among HIV-Positive Compared to HIV-Negative Veterans
Crothers K, Butt AA, Gibert CL, Rodriguez-Barradas MC, Crystal S, Justice AC, Team F. Increased COPD Among HIV-Positive Compared to HIV-Negative Veterans. CHEST Journal 2006, 130: 1326-1333. PMID: 17099007, DOI: 10.1378/chest.130.5.1326.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiretroviral Therapy, Highly ActiveDisease SusceptibilityHIV InfectionsHIV SeronegativityHIV SeropositivityHumansMaleMiddle AgedPrevalenceProspective StudiesPulmonary Disease, Chronic ObstructiveRisk FactorsVeteransConceptsInjection drug usePrevalence of COPDHIV-negative subjectsIndependent risk factorHIV infectionICD-9 codesRisk factorsDiagnostic codesAlcohol abuseICD-9 diagnostic codesHIV-negative veteransActive antiretroviral therapyHIV-positive patientsEra of HAARTHIV-negative menHIV-positive subjectsProspective observational studyPathogenesis of COPDRisk of COPDHealth care providersElectronic medical recordsRace/ethnicityAntiretroviral therapyHIV-positiveCigarette smoking
2005
The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorbid Illness Among HIV‐Positive Veterans
Crothers K, Griffith TA, McGinnis KA, Rodriguez‐Barradas M, Leaf DA, Weissman S, Gibert CL, Butt AA, Justice AC. The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorbid Illness Among HIV‐Positive Veterans. Journal Of General Internal Medicine 2005, 20: 1142-1145. PMID: 16423106, PMCID: PMC1490270, DOI: 10.1111/j.1525-1497.2005.0255.x.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityFemaleHIV InfectionsHumansLung DiseasesMaleMiddle AgedPneumonia, BacterialProspective StudiesPulmonary Disease, Chronic ObstructiveQuality of LifeSmokingVeteransConceptsChronic obstructive pulmonary diseaseQuality of lifeHIV-positive patientsImpact of smokingPhysical component summaryHIV-positive veteransCurrent smokersRespiratory symptomsBacterial pneumoniaActive antiretroviral therapyCD4 cell countHIV RNA levelsProspective observational studyObstructive pulmonary diseaseShort Form-12National VA databasesRace/ethnicityAntiretroviral therapyComorbid illnessesComponent summaryHIV infectionPatient questionnairePulmonary diseaseChart extractionCigarette smoking