2020
Serious Falls in Middle‐Aged Veterans: Development and Validation of a Predictive Risk Model
Womack JA, Murphy TE, Bathulapalli H, Smith A, Bates J, Jarad S, Redeker NS, Luther SL, Gill TM, Brandt CA, Justice AC. Serious Falls in Middle‐Aged Veterans: Development and Validation of a Predictive Risk Model. Journal Of The American Geriatrics Society 2020, 68: 2847-2854. PMID: 32860222, PMCID: PMC7744431, DOI: 10.1111/jgs.16773.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransVeterans Health AdministrationOpioid useSerious fallsAlcohol Use Disorders Identification Test-Consumption scoresCategory-free net reclassification improvementIllicit substance use disordersMental health comorbiditiesPrescription opioid useMultivariable logistic regressionNet reclassification improvementSubstance use disordersQuality of lifeHazardous alcohol usePredictive risk modelChronic medicationsCohort studyHealth comorbiditiesNinth RevisionReclassification improvementGeriatric healthInjury codesHazardous alcoholInternational ClassificationUse disorders
2016
HIV and ageing
Althoff KN, Smit M, Reiss P, Justice AC. HIV and ageing. Current Opinion In HIV And AIDS 2016, 11: 527-536. PMID: 27367780, PMCID: PMC5084838, DOI: 10.1097/coh.0000000000000305.Peer-Reviewed Original ResearchConceptsQuality of lifeAge-associated conditionsGeriatric syndromesHIV infectionCombination antiviral therapyModifiable risk factorsAge-associated comorbiditiesRole of HIVComplexity of careEvidence-based strategiesHarmful health behaviorsPhysiologic frailtyViral suppressionTreatment toxicityAntiretroviral agentsFragility fracturesAntiviral therapyViral coinfectionEffects of exposureRisk factorsCognitive dysfunctionHigh prevalenceHIVControllable illnessHealth behaviors
2011
Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy
Akgün KM, Huang L, Morris A, Justice AC, Pisani M, Crothers K. Critical Illness in HIV-Infected Patients in the Era of Combination Antiretroviral Therapy. Annals Of The American Thoracic Society 2011, 8: 301-307. PMID: 21653532, PMCID: PMC3132789, DOI: 10.1513/pats.201009-060wr.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyICU admissionCritical illnessAdministration of ARTImpact of ARTProportion of deathsHIV eraOpportunistic infectionsHIVAIDS epidemicMore recent studiesIllnessPatientsAdmissionTherapyRecent studiesICUEtiologyInfectionMortalityIncidenceDiseaseAdministration
2010
Patient and Provider-Reported Symptoms in the Post-cART Era
Edelman EJ, Gordon K, Justice AC. Patient and Provider-Reported Symptoms in the Post-cART Era. AIDS And Behavior 2010, 15: 853-861. PMID: 20490910, PMCID: PMC3118476, DOI: 10.1007/s10461-010-9706-z.Peer-Reviewed Original ResearchConceptsPatient-reported symptomsPost-cART eraClinical outcomesVeterans Aging Cohort StudyAging Cohort StudyHealth-related qualityBaseline survey dataCohort studySymptoms patientsHigh burdenSecondary analysisSymptomsPatientsPrimary providersGold standardKappa scoresHospitalizationRegression analysisMortalityOutcomesProvidersPoor agreementHRQoLHIVPrevalence
2009
Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans.
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Oursler KA, Goetz MB, Crystal S, Leaf DA, Butt AA, Braithwaite RS, Peck R, Justice AC. Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans. AIDS Education And Prevention 2009, 21: 40-53. PMID: 19537953, PMCID: PMC3118467, DOI: 10.1521/aeap.2009.21.3_supp.40.Peer-Reviewed Original ResearchConceptsHIV-negative veteransIncidence rate ratiosSmoking statusHIV-negative patientsSimilar mortality riskHIV-positive veteransComorbid diseasesCurrent smokingOverall mortalityCigarette smokingPoor outcomeMortality riskHIVPoisson regressionMortalitySmokingRate ratioVeteransDiseaseStudy of mechanismsLow levelsStatusSmokersPatientsCessation
2008
Quantifying the Decrement in Utility from Perceived Side Effects of Combination Antiretroviral Therapies in Patients with HIV
Braithwaite RS, Goulet J, Kudel I, Tsevat J, Justice AC. Quantifying the Decrement in Utility from Perceived Side Effects of Combination Antiretroviral Therapies in Patients with HIV. Value In Health 2008, 11: 975-979. PMID: 18225989, PMCID: PMC3121315, DOI: 10.1111/j.1524-4733.2007.00315.x.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyBothersome symptomsSF-6D utilitiesAntiretroviral therapyCD4 countSide effectsVeterans Aging Cohort StudyAging Cohort StudySF-12 scoresAfrican American raceHazardous alcohol consumptionQuality of lifeRecent drug useCART initiationMild anginaCohort studyMultivariable analysisCigarette smokingUnivariate analysisAmerican raceAlcohol consumptionDrug useUtility decrementsPatientsClinical decision
2006
Health‐Related Quality of Life in Veterans and Nonveterans with HIV/AIDS
Mrus JM, Leonard AC, Yi MS, Sherman SN, Fultz SL, Justice AC, Tsevat J. Health‐Related Quality of Life in Veterans and Nonveterans with HIV/AIDS. Journal Of General Internal Medicine 2006, 21: s39-s47. PMID: 17083499, PMCID: PMC1924783, DOI: 10.1111/j.1525-1497.2006.00644.x.Peer-Reviewed Original ResearchConceptsHIV/AIDSSymptom botherDepressive symptomsCorrelates of HRQOLPoorer overall functionDeterminants of HRQoLNon-VA settingsHealth-related qualityInjection drug useRating Scale scoresUnstable housing situationsVeterans Administration settingsQuality of lifeVeteran statusHealth valueOverall functionPoor HRQOLHRQOL outcomesMultivariable analysisHRQOL measuresMultivariable associationsMultivariable modelHRQoLVeteran populationHealth ratings
2005
The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorbid Illness Among HIV‐Positive Veterans
Crothers K, Griffith TA, McGinnis KA, Rodriguez‐Barradas M, Leaf DA, Weissman S, Gibert CL, Butt AA, Justice AC. The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorbid Illness Among HIV‐Positive Veterans. Journal Of General Internal Medicine 2005, 20: 1142-1145. PMID: 16423106, PMCID: PMC1490270, DOI: 10.1111/j.1525-1497.2005.0255.x.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseQuality of lifeHIV-positive patientsImpact of smokingPhysical component summaryHIV-positive veteransCurrent smokersRespiratory symptomsBacterial pneumoniaActive antiretroviral therapyCD4 cell countHIV RNA levelsProspective observational studyObstructive pulmonary diseaseShort Form-12National VA databasesRace/ethnicityAntiretroviral therapyComorbid illnessesComponent summaryHIV infectionPatient questionnairePulmonary diseaseChart extractionCigarette smoking
2001
Veterans aging cohort three-site study (VACS 3) overview and description
Smola S, Justice AC, Wagner J, Rabeneck L, Weissman S, Rodriguez-Barradas M, Team F. Veterans aging cohort three-site study (VACS 3) overview and description. Journal Of Clinical Epidemiology 2001, 54: s61-s76. PMID: 11750212, DOI: 10.1016/s0895-4356(01)00448-6.Peer-Reviewed Original ResearchConceptsHIV infectionProvider surveyVeterans Affairs Medical CenterMedian CD4 countVeterans Aging CohortMedian viral loadUse of cigarettesFuture clinical interventionsInfluence of ageCD4 countAntiretroviral medicationsComorbid diseasesDisease clinicViral loadPoor outcomeMean ageThree-site studyAlternative therapiesAge-related differencesCopies/Medical CenterHIVAging CohortTwelve-monthClinical interventionsDevelopment and validation of a self-completed HIV symptom index
Justice AC, Holmes W, Gifford AL, Rabeneck L, Zackin R, Sinclair G, Weissman S, Neidig J, Marcus C, Chesney M, Cohn SE, Wu AW, Committee F. Development and validation of a self-completed HIV symptom index. Journal Of Clinical Epidemiology 2001, 54: s77-s90. PMID: 11750213, DOI: 10.1016/s0895-4356(01)00449-8.Peer-Reviewed Original ResearchConceptsHIV Symptom IndexCD4 cell countSymptom IndexPatient-oriented researchProspective sampleClinical managementCleveland Veterans Affairs Medical CenterCell countDisease severityAIDS Clinical Trials GroupMental health summary scoresVeterans Affairs Medical CenterViral quantificationAdverse drug event reportingAdverse drug reportingExcellent completion ratesMultidrug antiretroviral therapyPatient-reported symptomsHealth-related qualityConvenience sampleClinical Trials GroupHealth summary scoresPhysician-assessed disease severityChi-square testAntiretroviral therapyClinical Importance of Provider-Reported HIV Symptoms Compared With Patient-Report
Justice AC, Chang CH, Rabeneck L, Zackin S. Clinical Importance of Provider-Reported HIV Symptoms Compared With Patient-Report. Medical Care 2001, 39: 397-408. PMID: 11329526, DOI: 10.1097/00005650-200104000-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHIV InfectionsHIV-1HumansMalePractice Patterns, Physicians'Quality of LifeSelf-AssessmentConceptsPatient-reported symptomsHIV-1 RNA levelsCD4 cell countRecent hospitalizationCell countSymptom ChecklistAdverse drug event monitoringRNA levelsCombination antiviral therapyHealth-related qualityPhysical health scalesHIV diseaseHIV infectionAntiviral therapyHRQOL subscalesMulticenter studyHIV symptomsClinical managementPatient reportsHospitalizationPatientsClinical importanceHealth ScaleSecondary analysisSymptoms
1999
Sensitivity, specificity, reliability, and clinical validity of provider-reported symptoms: a comparison with self-reported symptoms. Outcomes Committee of the AIDS Clinical Trials Group.
Justice AC, Rabeneck L, Hays RD, Wu AW, Bozzette SA. Sensitivity, specificity, reliability, and clinical validity of provider-reported symptoms: a comparison with self-reported symptoms. Outcomes Committee of the AIDS Clinical Trials Group. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1999, 21: 126-33. PMID: 10360804.Peer-Reviewed Original ResearchConceptsFunctional statusSymptom SurveyTest-retest reliabilityGlobal qualitySeverity scoreClinical validitySymptom measurementAIDS Clinical Trials GroupAdvanced HIV infectionSelf-reported symptom severityClinical Trials GroupSeverity of symptomsSymptom survey dataSelf-reported symptomsHIV infectionTreatment armsSymptom assessmentOutcomes CommitteeTrial groupSecondary data analysisPoor test-retest reliabilityHIV researchSymptom dataSymptom severitySymptoms