2023
Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study
Xu H, Toikumo S, Crist R, Glogowska K, Jinwala Z, Deak J, Justice A, Gelernter J, Johnson E, Kranzler H, Kember R. Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study. Addiction 2023, 118: 1942-1952. PMID: 37156939, PMCID: PMC10754226, DOI: 10.1111/add.16229.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSignificant single nucleotide polymorphismsSubstance use traitsMulti-trait analysisAssociation studiesGenetic architectureUse traitsGenome-wide significant single nucleotide polymorphismsProtein-protein interaction analysisTrait genetic architectureNumber of lociPolygenic risk scoresEuropean ancestry individualsNovel lociSingle nucleotide polymorphismsGenetic lociGWAS studiesLociMultiple related phenotypesNucleotide polymorphismsRelated phenotypesTraitsNovel associationsMTAgBiobank samples
2019
DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection
Mathur R, Hui Q, Huang Y, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection. The Journal Of Infectious Diseases 2019, 219: 1959-1962. PMID: 30649532, PMCID: PMC6534194, DOI: 10.1093/infdis/jiz023.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionHIV infection statusImmunodeficiency virus infectionVirus infectionVeterans Aging Cohort StudyType 2 diabetes mellitusInfection statusPancreatic β-cell functionAging Cohort StudyΒ-cell functionCohort studyDiabetes mellitusT2DM pathogenesisMale veteransType 2DNA methylation markersSuggestive interactionStatistical significanceMale participantsMellitusT2DMMethylation markersNovel associationsInfectionSuggestive statistical significance