2023
Racial and Ethnic Bias in the Diagnosis of Alcohol Use Disorder in Veterans
Vickers-Smith R, Justice A, Becker W, Rentsch C, Curtis B, Fernander A, Hartwell E, Ighodaro E, Kember R, Tate J, Kranzler H. Racial and Ethnic Bias in the Diagnosis of Alcohol Use Disorder in Veterans. American Journal Of Psychiatry 2023, 180: 426-436. PMID: 37132202, PMCID: PMC10238581, DOI: 10.1176/appi.ajp.21111097.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol consumptionAUD diagnosisHispanic veteransWhite veteransUse disordersPrevalence of AUDAlcohol Use Disorders Identification TestUnhealthy alcohol useICD-10 codesAUDIT-C scoresSelf-reported alcohol consumptionAlcohol-related disordersDiagnosis of AUDDisorders Identification TestMaximum scoreSelf-reported raceElectronic health recordsPrimary outcomeAlcohol consumption levelsPotential confoundersHigh prevalenceMillion Veteran ProgramGreater oddsICD-9Enhanced Identification of Hispanic Ethnicity Using Clinical Data
Ochoa-Allemant P, Tate J, Williams E, Gordon K, Marconi V, Bensley K, Rentsch C, Wang K, Taddei T, Justice A, Cohorts F. Enhanced Identification of Hispanic Ethnicity Using Clinical Data. Medical Care 2023, 61: 200-205. PMID: 36893404, PMCID: PMC10114212, DOI: 10.1097/mlr.0000000000001824.Peer-Reviewed Original ResearchConceptsBurden of diseaseHispanic patientsCountry of birthClinical dataHispanic ethnicityNon-Hispanic white patientsSex-adjusted prevalenceChronic liver diseaseHuman immunodeficiency virusDemographic characteristicsElectronic health record dataHealth careHealth record dataPrevalence of conditionsUS health care systemMedicare administrative dataHealth care systemWhite patientsLiver diseaseImmunodeficiency virusSelf-reported ethnicityHigh prevalenceGastric cancerHepatocellular carcinomaVeteran population
2021
Association of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection
Chichetto NE, Kundu S, Freiberg MS, Koethe JR, Butt AA, Crystal S, So-Armah KA, Cook RL, Braithwaite RS, Justice AC, Fiellin DA, Khan M, Bryant KJ, Gaither JR, Barve SS, Crothers K, Bedimo RJ, Warner A, Tindle HA. Association of Syndemic Unhealthy Alcohol Use, Smoking, and Depressive Symptoms on Incident Cardiovascular Disease among Veterans With and Without HIV-Infection. AIDS And Behavior 2021, 25: 2852-2862. PMID: 34101074, PMCID: PMC8376776, DOI: 10.1007/s10461-021-03327-4.Peer-Reviewed Original ResearchConceptsIncident cardiovascular diseaseUnhealthy alcohol useCardiovascular diseaseDepressive symptomsCVD riskHIV statusAlcohol useMultivariable Cox proportional hazards regressionCases of CVDCox proportional hazards regressionCVD-free participantsHIV-negative veteransProportional hazards regressionHIV-negativeHIV infectionHazards regressionSyndemic conditionsExcess riskRisk factorsDiagnostic codesHigh prevalenceObservational studyBaseline numberGreater riskSmokingExcess burden of age-associated comorbidities among people living with HIV in British Columbia, Canada: a population-based cohort study
Nanditha NGA, Paiero A, Tafessu HM, St-Jean M, McLinden T, Justice AC, Kopec J, Montaner JSG, Hogg RS, Lima VD. Excess burden of age-associated comorbidities among people living with HIV in British Columbia, Canada: a population-based cohort study. BMJ Open 2021, 11: e041734. PMID: 33419911, PMCID: PMC7799128, DOI: 10.1136/bmjopen-2020-041734.Peer-Reviewed Original ResearchConceptsHIV-negative controlsAge-associated comorbiditiesPopulation-based cohort studyCohort studyPrevalence trendsDiagnosis of comorbiditiesHIV-negative counterpartsNon-AIDS comorbiditiesHIV-negative individualsProvincial administrative databasesHIV care modelAdministrative health dataAge-associated conditionsLongitudinal cohort dataEarly ageAIDS comorbiditiesLiver diseaseEligible participantsLung diseaseAdministrative databasesHigh prevalencePLWHComorbiditiesCare modelKruskal-Wallis test
2019
Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study
Rentsch CT, Edelman EJ, Justice AC, Marshall BDL, Xu K, Smith AH, Crystal S, Gaither JR, Gordon AJ, Smith RV, Kember RL, Polimanti R, Gelernter J, Fiellin DA, Tate JP, Kranzler HR, Becker WC. Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study. AIDS And Behavior 2019, 23: 3340-3349. PMID: 31317364, PMCID: PMC7344341, DOI: 10.1007/s10461-019-02608-3.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid receiptCohort studyLong-term opioid therapyVeterans Aging Cohort StudyLatent growth mixture modellingPrescription opioid receiptObservational cohort studyAging Cohort StudyOpioid therapyCause mortalityHepatitis COpioid prescriptionsFuture prevention researchOUD diagnosisGrowth mixture modellingUS veteransHigh prevalenceLow doseHigh incidenceUse disordersPrevention researchGenetic discoveriesReceiptHIV
2017
Increased Echocardiographic Pulmonary Pressure in HIV-infected and -uninfected Individuals in the Veterans Aging Cohort Study
Brittain EL, Duncan MS, Chang J, Patterson OV, DuVall SL, Brandt CA, So-Armah KA, Goetz M, Akgun K, Crothers K, Zola C, Kim J, Gibert C, Pisani M, Morris A, Hsue P, Tindle HA, Justice A, Freiberg M. Increased Echocardiographic Pulmonary Pressure in HIV-infected and -uninfected Individuals in the Veterans Aging Cohort Study. American Journal Of Respiratory And Critical Care Medicine 2017, 197: 923-932. PMID: 29131651, PMCID: PMC6020408, DOI: 10.1164/rccm.201708-1555oc.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyCD4 cell countHIV viral loadAging Cohort StudyUninfected veteransPulmonary pressurePrevalent comorbiditiesCohort studyViral loadHigh prevalenceCell countLow CD4 cell countsHigher HIV viral loadAntiretroviral therapy eraRisk of deathRace/ethnicityPASP valuesTherapy eraAdjusted riskPulmonary hypertensionObservational cohortPrognostic impactPrimary outcomeClinical featuresHIV statusComplementary and Alternative Medicine Among Persons living with HIV in the Era of Combined Antiretroviral Treatment
Halpin SN, Carruth EC, Rai RP, Jennifer Edelman E, Fiellin DA, Gibert C, Gordon KS, Huang W, Justice A, Marconi VC, Rimland D, Perkins MM. Complementary and Alternative Medicine Among Persons living with HIV in the Era of Combined Antiretroviral Treatment. AIDS And Behavior 2017, 22: 848-852. PMID: 28733920, PMCID: PMC5939585, DOI: 10.1007/s10461-017-1866-7.Peer-Reviewed Original ResearchConceptsCAM useAlternative medicineVeterans Aging Cohort StudyAntiretroviral therapy eraCombined Antiretroviral TreatmentAging Cohort StudyTherapy eraBothersome symptomsCohort studyAntiretroviral treatmentCAM usersHigh prevalenceMore benzodiazepinesLess nicotineHIVTraditional treatmentPLWHCliniciansTreatmentMedicineOpioidsSymptomsBenzodiazepinesPrevalenceNicotine
2016
HIV and ageing
Althoff KN, Smit M, Reiss P, Justice AC. HIV and ageing. Current Opinion In HIV And AIDS 2016, 11: 527-536. PMID: 27367780, PMCID: PMC5084838, DOI: 10.1097/coh.0000000000000305.Peer-Reviewed Original ResearchConceptsQuality of lifeAge-associated conditionsGeriatric syndromesHIV infectionCombination antiviral therapyModifiable risk factorsAge-associated comorbiditiesRole of HIVComplexity of careEvidence-based strategiesHarmful health behaviorsPhysiologic frailtyViral suppressionTreatment toxicityAntiretroviral agentsFragility fracturesAntiviral therapyViral coinfectionEffects of exposureRisk factorsCognitive dysfunctionHigh prevalenceHIVControllable illnessHealth behaviors
2015
Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada
Koethe JR, Jenkins CA, Lau B, Shepherd BE, Justice AC, Tate JP, Buchacz K, Napravnik S, Mayor AM, Horberg MA, Blashill AJ, Willig A, Wester CW, Silverberg MJ, Gill J, Thorne JE, Klein M, Eron JJ, Kitahata MM, Sterling TR, Moore RD. Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada. AIDS Research And Human Retroviruses 2015, 32: 50-58. PMID: 26352511, PMCID: PMC4692122, DOI: 10.1089/aid.2015.0147.Peer-Reviewed Original ResearchConceptsYears of ARTBody mass indexAntiretroviral therapyART initiationMedian body mass indexNormal body mass indexHigher body mass indexWeight gainWhite womenUnited States National HealthART-exposed HIVHIV-1 RNAProportion of overweightMultivariable linear regressionCohort CollaborationNA-ACCORDNon-white womenCohort studyMedian ageObese adultsMass indexObesity prevalenceNational HealthHigh prevalenceHealth complications
2013
Does Social Isolation Predict Hospitalization and Mortality Among HIV+ and Uninfected Older Veterans?
Greysen SR, Horwitz LI, Covinsky KE, Gordon K, Ohl ME, Justice AC. Does Social Isolation Predict Hospitalization and Mortality Among HIV+ and Uninfected Older Veterans? Journal Of The American Geriatrics Society 2013, 61: 1456-1463. PMID: 23927911, PMCID: PMC3773301, DOI: 10.1111/jgs.12410.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudySocial isolation scoresHuman immunodeficiency virusCause mortalityHospital admissionUninfected groupOlder veteransSocial isolationGreater riskAging Cohort StudyHIV-positive individualsMultivariable regression analysisVA Medical CenterBaseline survey responsesUninfected participantsIncident hospitalizationCohort studyClinical featuresHIV statusImmunodeficiency virusHigh prevalenceMedical CenterMultivariable regressionHospitalizationOlder individuals
2012
HIV infection, aging, and immune function
Dubrow R, Silverberg MJ, Park LS, Crothers K, Justice AC. HIV infection, aging, and immune function. Current Opinion In Oncology 2012, 24: 506-516. PMID: 22759737, PMCID: PMC3695478, DOI: 10.1097/cco.0b013e328355e131.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV infectionCancer riskCancer preventionMore effective antiretroviral therapySustained antiretroviral therapyCombination antiretroviral therapyEffective antiretroviral therapyCancer risk factorsComplex chronic diseaseImmune system effectsSpecific cancer typesSystemic inflammationImmune dysfunctionChronic inflammationViral causeSmoking effectsLung cancerIndependent associationRisk factorsChronic diseasesHigh prevalenceCancer spectrumLiver cancerElevated riskHIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation. Clinical Infectious Diseases 2012, 55: 126-136. PMID: 22534147, PMCID: PMC3493182, DOI: 10.1093/cid/cis406.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationVeterans Aging Cohort StudyAltered coagulationMonocyte activationUninfected veteransCardiovascular diseaseElevated biomarkersComorbid conditionsHigh prevalenceCD4 cell countElevated IL-6Aging Cohort StudyOngoing HIV replicationPrevalent cardiovascular diseaseHIV-1 RNAHuman immunodeficiency virusCopies/mLElevated sCD14More dyslipidemiaCD4 countHepatitis CCohort studyComorbid diseasesCurrent smokingHIV infection
2010
Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort
Green TC, Kershaw T, Lin H, Heimer R, Goulet JL, Kraemer KL, Gordon AJ, Maisto SA, Day NL, Bryant K, Fiellin DA, Justice AC. Patterns of drug use and abuse among aging adults with and without HIV: A latent class analysis of a US Veteran cohort. Drug And Alcohol Dependence 2010, 110: 208-220. PMID: 20395074, PMCID: PMC3087206, DOI: 10.1016/j.drugalcdep.2010.02.020.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyHIV statusMultidrug usersDrug useLatent class analysisUS Veteran cohortAging Cohort StudyActive drug useSelf-reported drug useMental health disordersProblem of obesityElectronic medical recordsUninfected veteransCohort studyClinical variablesDrug use consequencesSocio-demographic covariatesMedical recordsHigh prevalenceUninfected adultsAge 50HIVHealth disordersDrug usersVeteran cohortThe Association Between Alcohol Consumption and Prevalent Cardiovascular Diseases Among HIV-Infected and HIV-Uninfected Men
Freiberg MS, McGinnis KA, Kraemer K, Samet JH, Conigliaro J, Ellison R, Bryant K, Kuller LH, Justice AC. The Association Between Alcohol Consumption and Prevalent Cardiovascular Diseases Among HIV-Infected and HIV-Uninfected Men. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2010, 53: 247-253. PMID: 20009766, PMCID: PMC2858978, DOI: 10.1097/qai.0b013e3181c6c4b7.Peer-Reviewed Original ResearchConceptsPrevalent cardiovascular diseaseCardiovascular diseaseAlcohol consumptionHigh prevalenceAlcohol abuseHazardous drinkingRisk factorsOdds ratioModerate drinkingTraditional CVD risk factorsVeterans Aging Cohort StudyCVD risk factorsTraditional risk factorsAging Cohort StudyHIV-uninfected (HIV-) menHIV-InfectedSimilar HIVAntiretroviral therapyCD4 countCohort studyProspective cohortPast drinkersKidney diseaseHIVLogistic regression
2005
Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans
Goulet JL, Fultz SL, McGinnis KA, Justice AC. Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AIDS 2005, 19: s99-s105. PMID: 16251836, DOI: 10.1097/01.aids.0000192077.11067.e5.Peer-Reviewed Original ResearchConceptsHIV/HCV-coHepatitis C virusAlcohol-related complicationsComorbid conditionsHCV-coTreatment optionsHIV monoChart extractionDiagnostic codesMental disordersCo-infected patientsElectronic medical record systemTreatment contraindicationsMedical record systemC virusHigh prevalenceMedical disordersHIVDemographic dataComorbiditiesLogistic regressionPrevalenceModerate agreementRelative prevalenceVeterans
2004
Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care
Justice AC, McGinnis KA, Atkinson JH, Heaton RK, Young C, Sadek J, Madenwald T, Becker JT, Conigliaro J, Brown ST, Rimland D, Crystal S, Simberkoff M. Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care. AIDS 2004, 18: 49-59. PMID: 15075498, DOI: 10.1097/00002030-200401001-00008.Peer-Reviewed Original ResearchConceptsHIV-negative subjectsHIV-positive subjectsNeurocognitive disordersDepressive symptomsAlcohol abuseDrug abuseHIV-negative veteransVeterans Aging CohortGeneral medicine clinicHIV-positive veteransSymptoms of depressionMemory problemsConvenience subsetOlder HIVHIV infectionMedicine clinicPsychiatric testingHigh prevalencePatient reportsSubstantial prevalenceGreater prevalenceAvailable measuresAging CohortNeurocognitive problemsInfectious diseases