2021
Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015
Sun J, Althoff KN, Jing Y, Horberg MA, Buchacz K, Gill MJ, Justice AC, Rabkin CS, Goedert JJ, Sigel K, Cachay E, Park L, Lim JK, Kim HN, Re V, Moore R, Sterling T, Peters MG, Achenbach CJ, Silverberg M, Thorne JE, Mayor AM, Crane HM, Kitahata MM, Klein M, Kirk GD. Trends in Hepatocellular Carcinoma Incidence and Risk Among Persons With HIV in the US and Canada, 1996-2015. JAMA Network Open 2021, 4: e2037512. PMID: 33595662, PMCID: PMC7890526, DOI: 10.1001/jamanetworkopen.2020.37512.Peer-Reviewed Original ResearchConceptsHCC incidence ratesHigher HCC riskHepatitis C virusHepatitis B virusModern cART eraCD4 cell countIncidence rateCART eraHCC riskHepatocellular carcinomaCohort studyTriple infectionNorth American AIDS Cohort CollaborationCell countAvailable CD4 cell countHigher HIV RNA levelsLow CD4 cell countsCombination antiretroviral therapy eraDiagnosis of HCCAnti-HCV seropositivityAntiretroviral therapy eraHBV-HCV coinfectionRecent HIV RNAHIV RNA levelsHBV e antigen
2018
Brief Report
Yanik EL, Hernández-Ramírez RU, Qin L, Lin H, Leyden W, Neugebauer RS, Horberg MA, Moore RD, Mathews WC, Justice AC, Hessol NA, Mayor AM, Gill MJ, Brooks JT, Sun J, Althoff KN, Engels EA, Silverberg MJ, Dubrow R. Brief Report. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 78: 499-504. PMID: 29771785, PMCID: PMC6037538, DOI: 10.1097/qai.0000000000001719.Peer-Reviewed Original ResearchConceptsMelanoma incidenceAntiretroviral therapyGeneral populationMelanoma riskNorth American AIDS Cohort CollaborationRelationship of immunosuppressionWhite general populationHIV RNA levelsStandardized incidence ratiosCutaneous melanoma incidenceUltraviolet B exposureHigher melanoma incidenceHigh UVB exposureCohort CollaborationSkin surveillanceCD4 countHIV RNAImmune dysfunctionIncidence ratiosCox regressionHIV replicationRisk factorsCalendar periodWhite raceClinical care
2014
Adjudicated Morbidity and Mortality Outcomes by Age among Individuals with HIV Infection on Suppressive Antiretroviral Therapy
Miller CJ, Baker JV, Bormann AM, Erlandson KM, Huppler Hullsiek K, Justice AC, Neuhaus J, Paredes R, Petoumenos K, Wentworth D, Winston A, Wolfson J, Neaton JD, . Adjudicated Morbidity and Mortality Outcomes by Age among Individuals with HIV Infection on Suppressive Antiretroviral Therapy. PLOS ONE 2014, 9: e95061. PMID: 24728071, PMCID: PMC3984283, DOI: 10.1371/journal.pone.0095061.Peer-Reviewed Original ResearchConceptsSerious non-AIDS eventsNon-AIDS eventsComposite outcomeAntiretroviral therapyCardiovascular diseaseSuppressive combination antiretroviral therapyEnd-stage renal diseaseEndpoint review committeeFive-year KaplanNon-AIDS cancerCombination antiretroviral therapyHIV RNA levelsSerious adverse eventsSuppressive antiretroviral therapyCause of morbidityLarge international trialCause of deathStudies of interventionsPre-specified criteriaCause mortalityAdverse eventsAIDS eventsEffect of ageMeier estimatesBaseline factors
2012
Impact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries
del Amo J, Moreno S, Bucher HC, Furrer H, Logan R, Sterne J, Pérez-Hoyos S, Jarrín I, Phillips A, Lodi S, van Sighem A, de Wolf W, Sabin C, Bansi L, Justice A, Goulet J, Miró JM, Ferrer E, Meyer L, Seng R, Toulomi G, Gargalianos P, Costagliola D, Abgrall S, Hernán MA. Impact of Antiretroviral Therapy on Tuberculosis Incidence Among HIV-Positive Patients in High-Income Countries. Clinical Infectious Diseases 2012, 54: 1364-1372. PMID: 22460971, PMCID: PMC3404691, DOI: 10.1093/cid/cis203.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAnti-HIV AgentsCD4 Lymphocyte CountCohort StudiesDeveloped CountriesDrug Therapy, CombinationEuropeFemaleHIV InfectionsHIV SeropositivityHumansImmune Reconstitution Inflammatory SyndromeIncidenceMaleMiddle AgedMycobacterium tuberculosisPneumocystis cariniiPneumonia, PneumocystisRNA, ViralTuberculosisUnited StatesViral LoadConceptsImmune reconstitution inflammatory syndromeCD4 cell countCells/μL.HIV RNA levelsHazard ratioTuberculosis incidenceCART initiationCell countAntiretroviral therapyTime-varying CD4 cell countBaseline CD4 cell countAIDS-free individualsEffects of CARTLow tuberculosis incidenceMonths of ARTReconstitution inflammatory syndromeHIV-positive patientsRNA levelsHIV-positive individualsHuman immunodeficiency virusHIV-CAUSAL CollaborationInflammatory syndromeImmunodeficiency virusInverse probability weightingPositive individuals
2010
HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era
Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC, Oursler KK, Rimland D, Gibert CL, Butt AA, Justice AC. HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era. American Journal Of Respiratory And Critical Care Medicine 2010, 183: 388-395. PMID: 20851926, PMCID: PMC3266024, DOI: 10.1164/rccm.201006-0836oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCombination antiretroviral therapy eraAntiretroviral therapy eraPulmonary diseaseTherapy eraPulmonary infectionHIV infectionVeterans Aging Cohort Study Virtual CohortIncident chronic obstructive pulmonary diseaseLower HIV RNA levelsVirtual cohortVeterans Affairs Healthcare SystemAssociation of HIVMost pulmonary diseasesHIV RNA levelsRates of asthmaIncidence rate ratiosSelf-reported smokingLarge Health SurveyPulmonary hypertensionUninfected patientsComorbid diseasesOpportunistic pneumoniaBacterial pneumonia
2009
Trends in Multidrug Treatment Failure and Subsequent Mortality among Antiretroviral Therapy-Experienced Patients with HIV Infection in North America
Deeks SG, Gange SJ, Kitahata MM, Saag MS, Justice AC, Hogg RS, Eron JJ, Brooks JT, Rourke SB, Gill MJ, Bosch RJ, Benson CA, Collier AC, Martin JN, Klein MB, Jacobson LP, Rodriguez B, Sterling TR, Kirk GD, Napravnik S, Rachlis AR, Calzavara LM, Horberg MA, Silverberg MJ, Gebo KA, Kushel MB, Goedert JJ, McKaig RG, Moore RD, Research and Design N. Trends in Multidrug Treatment Failure and Subsequent Mortality among Antiretroviral Therapy-Experienced Patients with HIV Infection in North America. Clinical Infectious Diseases 2009, 49: 1582-1590. PMID: 19845473, PMCID: PMC2871149, DOI: 10.1086/644768.Peer-Reviewed Original ResearchConceptsPlasma HIV RNA levelsCombination antiretroviral therapyHIV RNA levelsVirologic failureRegimen failureHistory of AIDSAntiretroviral therapyTreatment failureHigher plasma HIV RNA levelsAbility of therapyRNA levelsT-cell countsTreatment-naive patientsIndependent risk factorMultivariate Cox regressionAggressive therapeutic interventionMore effective optionsModified therapyHIV infectionCox regressionRisk factorsT cellsSubsequent mortalityMortality rateClinical practice
2005
Incidence of Tuberculosis among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Europe and North America
Girardi E, Sabin CA, d'Arminio Monforte A, Hogg B, Phillips AN, Gill MJ, Dabis F, Reiss P, Kirk O, Bernasconi E, Grabar S, Justice A, Staszewski S, Fätkenheuer G, Sterne JA. Incidence of Tuberculosis among HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy in Europe and North America. Clinical Infectious Diseases 2005, 41: 1772-1782. PMID: 16288403, DOI: 10.1086/498315.Peer-Reviewed Original ResearchConceptsIncidence of tuberculosisMonths of HAARTMultivariable analysisMultivariable Poisson regression modelsInitiation of HAARTLevel of immunodeficiencyLower baseline CD4Active antiretroviral therapyHIV RNA levelsRisk of tuberculosisInjection drug usersMode of transmissionPoisson regression modelsBaseline CD4HAART initiationHigher CD4Antiretroviral therapyTB epidemicIncidence rateCopies/HAARTDrug usersPatientsTuberculosisCD4The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorbid Illness Among HIV‐Positive Veterans
Crothers K, Griffith TA, McGinnis KA, Rodriguez‐Barradas M, Leaf DA, Weissman S, Gibert CL, Butt AA, Justice AC. The Impact of Cigarette Smoking on Mortality, Quality of Life, and Comorbid Illness Among HIV‐Positive Veterans. Journal Of General Internal Medicine 2005, 20: 1142-1145. PMID: 16423106, PMCID: PMC1490270, DOI: 10.1111/j.1525-1497.2005.0255.x.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseQuality of lifeHIV-positive patientsImpact of smokingPhysical component summaryHIV-positive veteransCurrent smokersRespiratory symptomsBacterial pneumoniaActive antiretroviral therapyCD4 cell countHIV RNA levelsProspective observational studyObstructive pulmonary diseaseShort Form-12National VA databasesRace/ethnicityAntiretroviral therapyComorbid illnessesComponent summaryHIV infectionPatient questionnairePulmonary diseaseChart extractionCigarette smoking