2023
Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review.
Wang L, Grimshaw A, Mezzacappa C, Rahimi Larki N, Yang Y, Justice A. Do Polygenic Risk Scores Add to Clinical Data in Predicting Pancreatic Cancer? A Scoping Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1490-1497. PMID: 37610426, PMCID: PMC10873036, DOI: 10.1158/1055-9965.epi-23-0468.Peer-Reviewed Original ResearchConceptsRoutine risk factorsPancreatic cancerRisk factorsPolygenic risk scoresClinical dataRisk scoreAddition of PRSClinical risk factorsRoutine clinical dataCancer risk predictionDatabase inceptionCancerClinical applicabilityRelevant exposuresGenetic riskRisk predictionCancer-specific polygenic risk scoresScoping ReviewRiskEuropean ancestryPopulation representativeScoresMost studiesAppropriate controlsFactors
2013
Association of the Veterans Aging Cohort Study Index with Exercise Capacity in HIV-Infected Adults
Oursler KK, Tate JP, Gill TM, Crothers K, Brown TT, Crystal S, Womack J, Leaf DA, Sorkin JD, Justice AC. Association of the Veterans Aging Cohort Study Index with Exercise Capacity in HIV-Infected Adults. AIDS Research And Human Retroviruses 2013, 29: 1218-1223. PMID: 23705911, PMCID: PMC3749694, DOI: 10.1089/aid.2012.0388.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort Study (VACS) IndexVACS IndexHigh riskLeg strengthMedian CD4 cell countStudy indicesMuscle cross-sectional areaPhysical disabilityVACS Index scoreCD4 cell countClinical risk factorsClinical laboratory valuesIdentification of patientsClinical blood testsRoutine clinical blood testsLower extremity strengthGreater mortality riskLower leg strengthQuality of lifeMiddle-aged adultsAfrican American menExercise capacityWalk distanceHIV infectionQuadriceps strength