2017
Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B
Justice AC, McGinnis KA, Tate JP, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR. Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. Alcohol Clinical And Experimental Research 2017, 41: 998-1003. PMID: 28295416, PMCID: PMC5501250, DOI: 10.1111/acer.13373.Peer-Reviewed Original ResearchConceptsHarmful alcohol useAlcohol exposureAlcohol useElectronic health record dataEHR dataAUDIT-C scoresHealth record dataLongitudinal electronic health record dataLongitudinal trajectoriesChi-square testEHR-derived phenotypesStudy cohortBlood drawCommon missense polymorphismGenetic risk variantsBlood samplingMissense polymorphismAlcohol riskQuantitative biomarkersRecord dataMedianRisk variantsOverall sampleAfrican AmericansADH1B gene
2001
Development and validation of a self-completed HIV symptom index
Justice AC, Holmes W, Gifford AL, Rabeneck L, Zackin R, Sinclair G, Weissman S, Neidig J, Marcus C, Chesney M, Cohn SE, Wu AW, Committee F. Development and validation of a self-completed HIV symptom index. Journal Of Clinical Epidemiology 2001, 54: s77-s90. PMID: 11750213, DOI: 10.1016/s0895-4356(01)00449-8.Peer-Reviewed Original ResearchConceptsHIV Symptom IndexCD4 cell countSymptom IndexPatient-oriented researchProspective sampleClinical managementCleveland Veterans Affairs Medical CenterCell countDisease severityAIDS Clinical Trials GroupMental health summary scoresVeterans Affairs Medical CenterViral quantificationAdverse drug event reportingAdverse drug reportingExcellent completion ratesMultidrug antiretroviral therapyPatient-reported symptomsHealth-related qualityConvenience sampleClinical Trials GroupHealth summary scoresPhysician-assessed disease severityChi-square testAntiretroviral therapy